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Prognostic significance of perioperative change of CEA level in colorectal patients when pre-operative level is normal.
Hepatogastroenterology. 2012 May; 59(115):717-20.H

Abstract

BACKGROUND/AIMS

The prognostic role of serum carcinoembryonic antigen (CEA) in colorectal cancer patients with normal preoperative level is questionable. We evaluate the perioperative change of serum CEA to elucidate its prognostic effect in these patients.

METHODOLOGY

We reviewed patients who received curative resection of colorectal cancer during 2000 and 2004 at Taipei Veterans General Hospital. The serum CEA level at diagnosis and one month after curative surgery were recorded. Levels higher than 5ng/mL were defined as abnormal. We divided patients with normal preoperative CEA level into two groups depending on the perioperative change. They were analyzed with clinicopathological factors and disease free survival rate.

RESULTS

In patients with stage I to III colorectal cancer, there were 738 patients with normal preoperative CEA level (55.7%). Patients with increased post-operative CEA than pre-operative ones had higher percentage of colon cancer (p=0.007) and more lymphovascular invasion (p=0.038). Besides they also had higher disease recurrent rate (p=0.032) and worse disease-free survival (p=0.019). In multivariate analysis, perioperative CEA change, lymph node metastasis and tumor invasion depth remained independent prognostic factors (p=0.015).

CONCLUSIONS

When preoperative CEA level is normal, perioperative change is a prognostic factor of colorectal cancer.

Authors+Show Affiliations

Department of Surgery, Taipei Veterans General Hospital, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22024225

Citation

Lan, Yuan-Tzu, et al. "Prognostic Significance of Perioperative Change of CEA Level in Colorectal Patients when Pre-operative Level Is Normal." Hepato-gastroenterology, vol. 59, no. 115, 2012, pp. 717-20.
Lan YT, Lin JK, Lin TC, et al. Prognostic significance of perioperative change of CEA level in colorectal patients when pre-operative level is normal. Hepatogastroenterology. 2012;59(115):717-20.
Lan, Y. T., Lin, J. K., Lin, T. C., Chen, W. S., Jiang, J. K., Wang, H. S., Chang, S. C., & Yang, S. H. (2012). Prognostic significance of perioperative change of CEA level in colorectal patients when pre-operative level is normal. Hepato-gastroenterology, 59(115), 717-20. https://doi.org/10.5754/hge10687a
Lan YT, et al. Prognostic Significance of Perioperative Change of CEA Level in Colorectal Patients when Pre-operative Level Is Normal. Hepatogastroenterology. 2012;59(115):717-20. PubMed PMID: 22024225.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prognostic significance of perioperative change of CEA level in colorectal patients when pre-operative level is normal. AU - Lan,Yuan-Tzu, AU - Lin,Jen-Kou, AU - Lin,Tzu-Chen, AU - Chen,Wei-Shone, AU - Jiang,Jeng-Kai, AU - Wang,Huann-Sheng, AU - Chang,Shih-Ching, AU - Yang,Shung-Haur, PY - 2011/10/26/entrez PY - 2011/10/26/pubmed PY - 2012/7/3/medline SP - 717 EP - 20 JF - Hepato-gastroenterology JO - Hepatogastroenterology VL - 59 IS - 115 N2 - BACKGROUND/AIMS: The prognostic role of serum carcinoembryonic antigen (CEA) in colorectal cancer patients with normal preoperative level is questionable. We evaluate the perioperative change of serum CEA to elucidate its prognostic effect in these patients. METHODOLOGY: We reviewed patients who received curative resection of colorectal cancer during 2000 and 2004 at Taipei Veterans General Hospital. The serum CEA level at diagnosis and one month after curative surgery were recorded. Levels higher than 5ng/mL were defined as abnormal. We divided patients with normal preoperative CEA level into two groups depending on the perioperative change. They were analyzed with clinicopathological factors and disease free survival rate. RESULTS: In patients with stage I to III colorectal cancer, there were 738 patients with normal preoperative CEA level (55.7%). Patients with increased post-operative CEA than pre-operative ones had higher percentage of colon cancer (p=0.007) and more lymphovascular invasion (p=0.038). Besides they also had higher disease recurrent rate (p=0.032) and worse disease-free survival (p=0.019). In multivariate analysis, perioperative CEA change, lymph node metastasis and tumor invasion depth remained independent prognostic factors (p=0.015). CONCLUSIONS: When preoperative CEA level is normal, perioperative change is a prognostic factor of colorectal cancer. SN - 0172-6390 UR - https://www.unboundmedicine.com/medline/citation/22024225/Prognostic_significance_of_perioperative_change_of_CEA_level_in_colorectal_patients_when_pre_operative_level_is_normal_ L2 - https://medlineplus.gov/colorectalcancer.html DB - PRIME DP - Unbound Medicine ER -