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Selenium and asthma.
Mol Aspects Med 2012; 33(1):98-106MA

Abstract

Se is a potent nutritional antioxidant important for various aspects of human health. Because asthma has been demonstrated to involve increased oxidative stress, levels of Se intake have been hypothesized to play an important role in the pathogenesis of asthma. However, significant associations between Se status and prevalence or severity of asthma have not been consistently demonstrated in human studies. This highlights both the complex etiology of human asthma and the inherent problems with correlative nutritional studies. In this review, the different findings in human studies are discussed along with results from limited intervention studies. Mouse models of asthma have provided more definitive results suggesting that the benefits of Se supplementation may depend on an individual's initial Se status. This likely involves T helper cell differentiation and the mechanistic studies that have provided important insight into the effects of Se levels on immune cell function are summarized. Importantly, the benefits and adverse effects of Se supplementation must both be considered in using this nutritional supplement for treating asthma. With this in mind new approaches are discussed that may provide more safe and effective means for using Se supplementation for asthma or other disorders involving inflammation or immunity.

Authors+Show Affiliations

Department of Cell and Molecular Biology, John A Burns School of Medicine, University of Hawaii, Honolulu, HI 96813, USA.No affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Review

Language

eng

PubMed ID

22024250

Citation

Norton, Robert L., and Peter R. Hoffmann. "Selenium and Asthma." Molecular Aspects of Medicine, vol. 33, no. 1, 2012, pp. 98-106.
Norton RL, Hoffmann PR. Selenium and asthma. Mol Aspects Med. 2012;33(1):98-106.
Norton, R. L., & Hoffmann, P. R. (2012). Selenium and asthma. Molecular Aspects of Medicine, 33(1), pp. 98-106. doi:10.1016/j.mam.2011.10.003.
Norton RL, Hoffmann PR. Selenium and Asthma. Mol Aspects Med. 2012;33(1):98-106. PubMed PMID: 22024250.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Selenium and asthma. AU - Norton,Robert L, AU - Hoffmann,Peter R, Y1 - 2011/10/15/ PY - 2011/07/27/received PY - 2011/10/05/revised PY - 2011/10/09/accepted PY - 2011/10/26/entrez PY - 2011/10/26/pubmed PY - 2012/5/1/medline SP - 98 EP - 106 JF - Molecular aspects of medicine JO - Mol. Aspects Med. VL - 33 IS - 1 N2 - Se is a potent nutritional antioxidant important for various aspects of human health. Because asthma has been demonstrated to involve increased oxidative stress, levels of Se intake have been hypothesized to play an important role in the pathogenesis of asthma. However, significant associations between Se status and prevalence or severity of asthma have not been consistently demonstrated in human studies. This highlights both the complex etiology of human asthma and the inherent problems with correlative nutritional studies. In this review, the different findings in human studies are discussed along with results from limited intervention studies. Mouse models of asthma have provided more definitive results suggesting that the benefits of Se supplementation may depend on an individual's initial Se status. This likely involves T helper cell differentiation and the mechanistic studies that have provided important insight into the effects of Se levels on immune cell function are summarized. Importantly, the benefits and adverse effects of Se supplementation must both be considered in using this nutritional supplement for treating asthma. With this in mind new approaches are discussed that may provide more safe and effective means for using Se supplementation for asthma or other disorders involving inflammation or immunity. SN - 1872-9452 UR - https://www.unboundmedicine.com/medline/citation/22024250/Selenium_and_asthma_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0098-2997(11)00047-1 DB - PRIME DP - Unbound Medicine ER -