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Mucins differently expressed in various ampullary adenocarcinomas.
Diagn Pathol 2011; 6:102DP

Abstract

BACKGROUND

We investigated the occurrence and clinical significance of mucin expression in ampullary adenocarcinoma.

METHODS

We retrospectively analyzed clinical, pathological, and survival data from 74 ampullary adenocarcinoma patients who received radical operation from January 2004 to November 2006.

RESULTS

The tumors were located in the lower end of the common bile duct (46%), papillary duodenum (42%), and ampullary duodenum (12%), and expressed MUC1 (72%), MUC2 (20%), MUC5AC (43%), and MUC6 (27%). Expression of MUC1 was associated with tumor differentiation (OR: 4.71, 95% CI: 1.26, 17.66, P = 0.021). Expression of MUC5AC was associated with age (OR: 1.07, 95% CI: 1.11, 1.14, P = 0.026) and less vessel invasion(OR: 0.14, 95% CI: 0.03, 0.72, P = 0.019). The survival rates were not significantly different when patients had or had no expression of MUC1, MUC2, MUC5AC, or MUC6 in tumor. Patients with tumors positive for MUC5AC in the papillary duodenum had worse survival than those with tumors negative for MUC5AC (P = 0.044).

CONCLUSIONS

Expression of MUC1 was high (72%) in ampullary adenocarcinoma, while expressions of MUC2, MUC5AC, and MUC6 were lower. Mucins are useful markers to diagnose and identify ampullary adenocarcinoma, particularly in determining the degree of malignancy of ampullary adenocarcinoma.

Authors+Show Affiliations

Department of Radiation Oncology, QiLu Hospital of Shandong University, Shandong, China.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22027009

Citation

Wang, Tao, et al. "Mucins Differently Expressed in Various Ampullary Adenocarcinomas." Diagnostic Pathology, vol. 6, 2011, p. 102.
Wang T, Liang YM, Hu P, et al. Mucins differently expressed in various ampullary adenocarcinomas. Diagn Pathol. 2011;6:102.
Wang, T., Liang, Y. M., Hu, P., & Cheng, Y. F. (2011). Mucins differently expressed in various ampullary adenocarcinomas. Diagnostic Pathology, 6, p. 102. doi:10.1186/1746-1596-6-102.
Wang T, et al. Mucins Differently Expressed in Various Ampullary Adenocarcinomas. Diagn Pathol. 2011 Oct 25;6:102. PubMed PMID: 22027009.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mucins differently expressed in various ampullary adenocarcinomas. AU - Wang,Tao, AU - Liang,Ye M, AU - Hu,Peng, AU - Cheng,Yu F, Y1 - 2011/10/25/ PY - 2011/06/29/received PY - 2011/10/25/accepted PY - 2011/10/27/entrez PY - 2011/10/27/pubmed PY - 2012/1/24/medline SP - 102 EP - 102 JF - Diagnostic pathology JO - Diagn Pathol VL - 6 N2 - BACKGROUND: We investigated the occurrence and clinical significance of mucin expression in ampullary adenocarcinoma. METHODS: We retrospectively analyzed clinical, pathological, and survival data from 74 ampullary adenocarcinoma patients who received radical operation from January 2004 to November 2006. RESULTS: The tumors were located in the lower end of the common bile duct (46%), papillary duodenum (42%), and ampullary duodenum (12%), and expressed MUC1 (72%), MUC2 (20%), MUC5AC (43%), and MUC6 (27%). Expression of MUC1 was associated with tumor differentiation (OR: 4.71, 95% CI: 1.26, 17.66, P = 0.021). Expression of MUC5AC was associated with age (OR: 1.07, 95% CI: 1.11, 1.14, P = 0.026) and less vessel invasion(OR: 0.14, 95% CI: 0.03, 0.72, P = 0.019). The survival rates were not significantly different when patients had or had no expression of MUC1, MUC2, MUC5AC, or MUC6 in tumor. Patients with tumors positive for MUC5AC in the papillary duodenum had worse survival than those with tumors negative for MUC5AC (P = 0.044). CONCLUSIONS: Expression of MUC1 was high (72%) in ampullary adenocarcinoma, while expressions of MUC2, MUC5AC, and MUC6 were lower. Mucins are useful markers to diagnose and identify ampullary adenocarcinoma, particularly in determining the degree of malignancy of ampullary adenocarcinoma. SN - 1746-1596 UR - https://www.unboundmedicine.com/medline/citation/22027009/Mucins_differently_expressed_in_various_ampullary_adenocarcinomas_ L2 - https://diagnosticpathology.biomedcentral.com/articles/10.1186/1746-1596-6-102 DB - PRIME DP - Unbound Medicine ER -