Tags

Type your tag names separated by a space and hit enter

Green tea catechins decrease total and low-density lipoprotein cholesterol: a systematic review and meta-analysis.

Abstract

Green tea catechins (GTCs) have been studied in randomized control trials for their lipid-lowering effects. Studies, however, have been small and demonstrated conflicting results. The objective of this study was to perform a systematic review and meta-analysis of randomized controlled trials evaluating the relationship between GTCs and serum lipid levels, including total, low-density lipoprotein (LDL), high-density lipoprotein (HDL) cholesterol, and triglycerides. A systematic literature search of MEDLINE, EMBASE, Cochrane CENTRAL, and the Natural Medicines Comprehensive Database was conducted through March 2010. Randomized controlled trials evaluating GTCs vs control in human beings and reporting efficacy data on at least one of the aforementioned serum lipid endpoints were included. Weighted mean differences for changes from baseline (with 95% confidence intervals [CIs]) for lipid endpoints were calculated using random-effects models. Twenty trials (N=1,415) met all inclusion criteria. Upon meta-analysis, GTCs at doses ranging from 145 to 3,000 mg/day taken for 3 to 24 weeks reduced total (-5.46 mg/dL [-0.14 mmol/L]; 95% CI -9.59 to -1.32) and LDL cholesterol (-5.30 mg/dL [-0.14 mmol/L]; 95% CI -9.99 to -0.62) compared to control. GTCs did not significantly alter HDL cholesterol (-0.27 mg/dL [-0.007 mmol/L]; 95% CI -1.62 to 1.09) or triglyceride (3.00 mg/dL [-0.034 mmol/L]; 95% CI -2.73 to 8.73) levels. The consumption of GTCs is associated with a statistically significant reduction in total and LDL cholesterol levels; however, there was no significant effect on HDL cholesterol or triglyceride levels.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    University of Connecticut School of Pharmacy, Hartford, CT, USA.

    , , , , ,

    Source

    MeSH

    Anticholesteremic Agents
    Catechin
    Cholesterol
    Cholesterol, HDL
    Cholesterol, LDL
    Dose-Response Relationship, Drug
    Humans
    Lipid Metabolism
    Randomized Controlled Trials as Topic
    Tea
    Triglycerides

    Pub Type(s)

    Journal Article
    Meta-Analysis
    Review
    Systematic Review

    Language

    eng

    PubMed ID

    22027055

    Citation

    Kim, Amie, et al. "Green Tea Catechins Decrease Total and Low-density Lipoprotein Cholesterol: a Systematic Review and Meta-analysis." Journal of the American Dietetic Association, vol. 111, no. 11, 2011, pp. 1720-9.
    Kim A, Chiu A, Barone MK, et al. Green tea catechins decrease total and low-density lipoprotein cholesterol: a systematic review and meta-analysis. J Am Diet Assoc. 2011;111(11):1720-9.
    Kim, A., Chiu, A., Barone, M. K., Avino, D., Wang, F., Coleman, C. I., & Phung, O. J. (2011). Green tea catechins decrease total and low-density lipoprotein cholesterol: a systematic review and meta-analysis. Journal of the American Dietetic Association, 111(11), pp. 1720-9. doi:10.1016/j.jada.2011.08.009.
    Kim A, et al. Green Tea Catechins Decrease Total and Low-density Lipoprotein Cholesterol: a Systematic Review and Meta-analysis. J Am Diet Assoc. 2011;111(11):1720-9. PubMed PMID: 22027055.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Green tea catechins decrease total and low-density lipoprotein cholesterol: a systematic review and meta-analysis. AU - Kim,Amie, AU - Chiu,Andrew, AU - Barone,Meredith K, AU - Avino,Diane, AU - Wang,Fei, AU - Coleman,Craig I, AU - Phung,Olivia J, PY - 2011/01/13/received PY - 2011/05/05/accepted PY - 2011/10/27/entrez PY - 2011/10/27/pubmed PY - 2011/12/13/medline SP - 1720 EP - 9 JF - Journal of the American Dietetic Association JO - J Am Diet Assoc VL - 111 IS - 11 N2 - Green tea catechins (GTCs) have been studied in randomized control trials for their lipid-lowering effects. Studies, however, have been small and demonstrated conflicting results. The objective of this study was to perform a systematic review and meta-analysis of randomized controlled trials evaluating the relationship between GTCs and serum lipid levels, including total, low-density lipoprotein (LDL), high-density lipoprotein (HDL) cholesterol, and triglycerides. A systematic literature search of MEDLINE, EMBASE, Cochrane CENTRAL, and the Natural Medicines Comprehensive Database was conducted through March 2010. Randomized controlled trials evaluating GTCs vs control in human beings and reporting efficacy data on at least one of the aforementioned serum lipid endpoints were included. Weighted mean differences for changes from baseline (with 95% confidence intervals [CIs]) for lipid endpoints were calculated using random-effects models. Twenty trials (N=1,415) met all inclusion criteria. Upon meta-analysis, GTCs at doses ranging from 145 to 3,000 mg/day taken for 3 to 24 weeks reduced total (-5.46 mg/dL [-0.14 mmol/L]; 95% CI -9.59 to -1.32) and LDL cholesterol (-5.30 mg/dL [-0.14 mmol/L]; 95% CI -9.99 to -0.62) compared to control. GTCs did not significantly alter HDL cholesterol (-0.27 mg/dL [-0.007 mmol/L]; 95% CI -1.62 to 1.09) or triglyceride (3.00 mg/dL [-0.034 mmol/L]; 95% CI -2.73 to 8.73) levels. The consumption of GTCs is associated with a statistically significant reduction in total and LDL cholesterol levels; however, there was no significant effect on HDL cholesterol or triglyceride levels. SN - 1878-3570 UR - https://www.unboundmedicine.com/medline/citation/22027055/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-8223(11)01379-4 DB - PRIME DP - Unbound Medicine ER -