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Xanthogranuloma of the sellar region of children: series of five cases and literature review.
Neurol Med Chir (Tokyo). 2011; 51(10):689-93.NM

Abstract

Five Japanese children presented with rare xanthogranuloma located in the sellar region between 2000 and 2010 at the Department of Neurosurgery, Hokkaido University Hospital. Endocrinological examination disclosed central diabetes in four patients. Preoperative magnetic resonance (MR) imaging and computed tomography (CT) demonstrated clearly defined intra- or suprasellar masses appearing as isointense or hyperintense on T(1)-weighted MR imaging with no calcification on CT. The tumor was totally removed under preoperative diagnosis of craniopharyngioma in all cases. Histological examination found fibrous tissue with abundant cholesterol clefts and hemosiderin deposits, but no or only tiny amounts of epithelial cells in each case. Therefore, the histological diagnoses were xanthogranuloma of the sellar region, not adamantinomatous craniopharyngioma. Postoperatively, no patient recovered from endocrinological deficits, whereas visual disturbances were improved immediately after operation. Currently, whether xanthogranuloma is distinct from adamantinomatous craniopharyngioma remains unclear. Only a few clinical reports of xanthogranuloma of the sellar region have been reported in pediatric patients. Our series shows that xanthogranuloma should be included in the differential diagnosis of pediatric tumor of the sellar region.

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Authors+Show Affiliations

Kamoshima Y
Department of Neurosurgery, Graduate School of Medicine, Hokkaido University, North-15 West-7, Kita-ku, Sapporo, Japan. kamoshima2002@yahoo.co.jp
Sawamura Y
No affiliation info available
Motegi H
No affiliation info available
Kubota K
No affiliation info available
Houkin K
No affiliation info available

MeSH

ChildChild, PreschoolCraniopharyngiomaDiagnosis, DifferentialFemaleHumansMaleRadiographySella TurcicaSkull Base NeoplasmsXanthogranuloma, Juvenile

Pub Type(s)

Case Reports
Journal Article
Review

Language

eng

PubMed ID

22027243

Citation

Kamoshima, Yuuta, et al. "Xanthogranuloma of the Sellar Region of Children: Series of Five Cases and Literature Review." Neurologia Medico-chirurgica, vol. 51, no. 10, 2011, pp. 689-93.
Kamoshima Y, Sawamura Y, Motegi H, et al. Xanthogranuloma of the sellar region of children: series of five cases and literature review. Neurol Med Chir (Tokyo). 2011;51(10):689-93.
Kamoshima, Y., Sawamura, Y., Motegi, H., Kubota, K., & Houkin, K. (2011). Xanthogranuloma of the sellar region of children: series of five cases and literature review. Neurologia Medico-chirurgica, 51(10), 689-93.
Kamoshima Y, et al. Xanthogranuloma of the Sellar Region of Children: Series of Five Cases and Literature Review. Neurol Med Chir (Tokyo). 2011;51(10):689-93. PubMed PMID: 22027243.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Xanthogranuloma of the sellar region of children: series of five cases and literature review. AU - Kamoshima,Yuuta, AU - Sawamura,Yutaka, AU - Motegi,Hiroaki, AU - Kubota,Kanako, AU - Houkin,Kiyohiro, PY - 2011/10/27/entrez PY - 2011/10/27/pubmed PY - 2012/8/23/medline SP - 689 EP - 93 JF - Neurologia medico-chirurgica JO - Neurol Med Chir (Tokyo) VL - 51 IS - 10 N2 - Five Japanese children presented with rare xanthogranuloma located in the sellar region between 2000 and 2010 at the Department of Neurosurgery, Hokkaido University Hospital. Endocrinological examination disclosed central diabetes in four patients. Preoperative magnetic resonance (MR) imaging and computed tomography (CT) demonstrated clearly defined intra- or suprasellar masses appearing as isointense or hyperintense on T(1)-weighted MR imaging with no calcification on CT. The tumor was totally removed under preoperative diagnosis of craniopharyngioma in all cases. Histological examination found fibrous tissue with abundant cholesterol clefts and hemosiderin deposits, but no or only tiny amounts of epithelial cells in each case. Therefore, the histological diagnoses were xanthogranuloma of the sellar region, not adamantinomatous craniopharyngioma. Postoperatively, no patient recovered from endocrinological deficits, whereas visual disturbances were improved immediately after operation. Currently, whether xanthogranuloma is distinct from adamantinomatous craniopharyngioma remains unclear. Only a few clinical reports of xanthogranuloma of the sellar region have been reported in pediatric patients. Our series shows that xanthogranuloma should be included in the differential diagnosis of pediatric tumor of the sellar region. SN - 1349-8029 UR - https://www.unboundmedicine.com/medline/citation/22027243/Xanthogranuloma_of_the_sellar_region_of_children:_series_of_five_cases_and_literature_review_ L2 - http://joi.jlc.jst.go.jp/JST.JSTAGE/nmc/51.689?from=PubMed DB - PRIME DP - Unbound Medicine ER -