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Effects of n-3 fatty acids on depressive symptoms and dispositional optimism after myocardial infarction.
Am J Clin Nutr 2011; 94(6):1442-50AJ

Abstract

BACKGROUND

In patients who have experienced a myocardial infarction (MI), n-3 (omega-3) PUFA status is low, whereas the risk of depression is increased.

OBJECTIVE

The objective was to assess whether the plant-derived α-linolenic acid (ALA) and the fish fatty acids EPA and DHA would improve affective states.

DESIGN

In a secondary analysis of the randomized, double-blind, placebo-controlled Alpha Omega Trial, 4116 of 4837 (85.1%) patients (aged 60-80 y; 79.2% men) who had experienced an MI were included. Margarine spreads were used to deliver 400 mg EPA-DHA/d, 2 g ALA/d, both EPA-DHA and ALA, or a placebo for 40 mo. At 40 mo, the endpoints of depressive symptoms (15-item Geriatric Depression Scale) and dispositional optimism (a 4-item questionnaire and the Life Orientation Test-Revised) were analyzed by using a posttest-only design.

RESULTS

The 4 randomly assigned groups did not differ in baseline characteristics. ALA supplementation significantly increased plasma cholesteryl ester concentrations of ALA by 69%, and EPA-DHA supplementation increased plasma cholesteryl ester concentrations of EPA and DHA by 61% and 30%, respectively. Depressive symptoms or dispositional optimism did not differ between groups with the use of n-3 fatty acids compared with placebo at the 40-mo follow-up. The standardized mean (±SE) differences in depressive symptoms were as follows: for EPA-DHA plus ALA (n = 1009) compared with placebo (n = 1030), -0.025 ± 0.044 (P = 0.57); for EPA-DHA (n = 1007) compared with placebo, -0.048 ± 0.044 (P = 0.28); and for ALA (n = 1022) compared with placebo, -0.047 ± 0.044 (P = 0.29).

CONCLUSIONS

In patients who had experienced an MI, low-dose EPA-DHA supplementation, ALA supplementation, or a combination of both did not affect depressive symptoms and dispositional optimism. These findings are in accord with those from previous trials in individuals without psychopathology or without severe depressive symptoms. This trial was registered at clinicaltrials.gov as NCT00127452.

Authors+Show Affiliations

Department of Psychiatry, Leiden University Medical Center, Netherlands. e.j.giltay@lumc.nlNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22030221

Citation

Giltay, Erik J., et al. "Effects of N-3 Fatty Acids On Depressive Symptoms and Dispositional Optimism After Myocardial Infarction." The American Journal of Clinical Nutrition, vol. 94, no. 6, 2011, pp. 1442-50.
Giltay EJ, Geleijnse JM, Kromhout D. Effects of n-3 fatty acids on depressive symptoms and dispositional optimism after myocardial infarction. Am J Clin Nutr. 2011;94(6):1442-50.
Giltay, E. J., Geleijnse, J. M., & Kromhout, D. (2011). Effects of n-3 fatty acids on depressive symptoms and dispositional optimism after myocardial infarction. The American Journal of Clinical Nutrition, 94(6), pp. 1442-50. doi:10.3945/ajcn.111.018259.
Giltay EJ, Geleijnse JM, Kromhout D. Effects of N-3 Fatty Acids On Depressive Symptoms and Dispositional Optimism After Myocardial Infarction. Am J Clin Nutr. 2011;94(6):1442-50. PubMed PMID: 22030221.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of n-3 fatty acids on depressive symptoms and dispositional optimism after myocardial infarction. AU - Giltay,Erik J, AU - Geleijnse,Johanna M, AU - Kromhout,Daan, Y1 - 2011/10/26/ PY - 2011/10/28/entrez PY - 2011/10/28/pubmed PY - 2012/2/4/medline SP - 1442 EP - 50 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 94 IS - 6 N2 - BACKGROUND: In patients who have experienced a myocardial infarction (MI), n-3 (omega-3) PUFA status is low, whereas the risk of depression is increased. OBJECTIVE: The objective was to assess whether the plant-derived α-linolenic acid (ALA) and the fish fatty acids EPA and DHA would improve affective states. DESIGN: In a secondary analysis of the randomized, double-blind, placebo-controlled Alpha Omega Trial, 4116 of 4837 (85.1%) patients (aged 60-80 y; 79.2% men) who had experienced an MI were included. Margarine spreads were used to deliver 400 mg EPA-DHA/d, 2 g ALA/d, both EPA-DHA and ALA, or a placebo for 40 mo. At 40 mo, the endpoints of depressive symptoms (15-item Geriatric Depression Scale) and dispositional optimism (a 4-item questionnaire and the Life Orientation Test-Revised) were analyzed by using a posttest-only design. RESULTS: The 4 randomly assigned groups did not differ in baseline characteristics. ALA supplementation significantly increased plasma cholesteryl ester concentrations of ALA by 69%, and EPA-DHA supplementation increased plasma cholesteryl ester concentrations of EPA and DHA by 61% and 30%, respectively. Depressive symptoms or dispositional optimism did not differ between groups with the use of n-3 fatty acids compared with placebo at the 40-mo follow-up. The standardized mean (±SE) differences in depressive symptoms were as follows: for EPA-DHA plus ALA (n = 1009) compared with placebo (n = 1030), -0.025 ± 0.044 (P = 0.57); for EPA-DHA (n = 1007) compared with placebo, -0.048 ± 0.044 (P = 0.28); and for ALA (n = 1022) compared with placebo, -0.047 ± 0.044 (P = 0.29). CONCLUSIONS: In patients who had experienced an MI, low-dose EPA-DHA supplementation, ALA supplementation, or a combination of both did not affect depressive symptoms and dispositional optimism. These findings are in accord with those from previous trials in individuals without psychopathology or without severe depressive symptoms. This trial was registered at clinicaltrials.gov as NCT00127452. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/22030221/Effects_of_n_3_fatty_acids_on_depressive_symptoms_and_dispositional_optimism_after_myocardial_infarction_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.111.018259 DB - PRIME DP - Unbound Medicine ER -