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Prospective association of vitamin D concentrations with mortality in postmenopausal women: results from the Women's Health Initiative (WHI).
Am J Clin Nutr. 2011 Dec; 94(6):1471-8.AJ

Abstract

BACKGROUND

Prospective epidemiologic data on the association between vitamin D and all-cause and cause-specific mortality are limited.

OBJECTIVE

This study aimed to determine whether 25-hydroxyvitamin D [25(OH)D] concentrations were prospectively and independently associated with cardiovascular disease (CVD), cancer, and all-cause mortality in postmenopausal women.

DESIGN

A substudy in 2429 postmenopausal women within the Women's Health Initiative (WHI) with measured baseline 25(OH)D concentrations were followed for 10 y for death from CVD, cancer, and all-cause mortality. Proportional hazards models were performed to evaluate quartiles of month-adjusted 25(OH)D concentrations, with adjustment for potential confounders. Sequential model building and analysis for multiplicative interaction were performed to evaluate the effects of central adiposity on the association of low 25(OH)D with all-cause mortality.

RESULTS

Of the 2429 women, 224 deaths occurred, with 79 deaths from CVD and 62 deaths from cancer. Multivariate-adjusted HRs that compared quartiles 1 (lowest) to 4 (highest) of 25(OH)D for all-cause mortality (HR: 1.25; 95% CI: 0.80, 1.95), CVD mortality (HR: 1.27; 95% CI: 0.81, 1.99), and cancer mortality (HR: 1.39; 95% CI: 0.88, 2.19) were not significant. There was a potential interaction (P = 0.08) between abdominal obesity and low 25(OH)D concentrations that showed an increased risk of the lowest quartile of 25(OH)D concentrations (HR: 1.85; 95% CI: 1.00, 3.44) with increased mortality in women with a normal waist circumference but no increased risk in women with abdominal obesity (HR: 0.96; 95% CI: 0.52, 1.76).

CONCLUSION

Body fat distribution may play an important role in the modulation of the effect of low vitamin D concentrations on health. This trial was registered at clinicaltrials.gov as NCT 00000611.

Links

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Authors+Show Affiliations

Eaton CB
Center for Primary Care and Prevention, Alpert Medical School of Brown University, Pawtucket, RI, USA. charles_eaton@mhri.org
Young A
No affiliation info available
Allison MA
No affiliation info available
Robinson J
No affiliation info available
Martin LW
No affiliation info available
Kuller LH
No affiliation info available
Johnson KC
No affiliation info available
Curb JD
No affiliation info available
Van Horn L
No affiliation info available
McTiernan A
No affiliation info available
Liu S
No affiliation info available
Manson JE
No affiliation info available

MeSH

AgedBody Fat DistributionCardiovascular DiseasesCause of DeathFemaleFollow-Up StudiesHumansMaleMiddle AgedNeoplasmsObesity, AbdominalPostmenopauseProportional Hazards ModelsProspective StudiesVitamin DVitamin D DeficiencyWaist Circumference

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

22030222

Clinical Trial Links

Clinical trial which this article describes

Citation

Eaton, Charles B., et al. "Prospective Association of Vitamin D Concentrations With Mortality in Postmenopausal Women: Results From the Women's Health Initiative (WHI)." The American Journal of Clinical Nutrition, vol. 94, no. 6, 2011, pp. 1471-8.
Eaton CB, Young A, Allison MA, et al. Prospective association of vitamin D concentrations with mortality in postmenopausal women: results from the Women's Health Initiative (WHI). Am J Clin Nutr. 2011;94(6):1471-8.
Eaton, C. B., Young, A., Allison, M. A., Robinson, J., Martin, L. W., Kuller, L. H., Johnson, K. C., Curb, J. D., Van Horn, L., McTiernan, A., Liu, S., & Manson, J. E. (2011). Prospective association of vitamin D concentrations with mortality in postmenopausal women: results from the Women's Health Initiative (WHI). The American Journal of Clinical Nutrition, 94(6), 1471-8. https://doi.org/10.3945/ajcn.111.017715
Eaton CB, et al. Prospective Association of Vitamin D Concentrations With Mortality in Postmenopausal Women: Results From the Women's Health Initiative (WHI). Am J Clin Nutr. 2011;94(6):1471-8. PubMed PMID: 22030222.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prospective association of vitamin D concentrations with mortality in postmenopausal women: results from the Women's Health Initiative (WHI). AU - Eaton,Charles B, AU - Young,Alicia, AU - Allison,Matthew A, AU - Robinson,Jennifer, AU - Martin,Lisa W, AU - Kuller,Lewis H, AU - Johnson,Karen C, AU - Curb,J David, AU - Van Horn,Linda, AU - McTiernan,Anne, AU - Liu,Simin, AU - Manson,JoAnn E, Y1 - 2011/10/26/ PY - 2011/10/28/entrez PY - 2011/10/28/pubmed PY - 2012/2/4/medline SP - 1471 EP - 8 JF - The American journal of clinical nutrition JO - Am J Clin Nutr VL - 94 IS - 6 N2 - BACKGROUND: Prospective epidemiologic data on the association between vitamin D and all-cause and cause-specific mortality are limited. OBJECTIVE: This study aimed to determine whether 25-hydroxyvitamin D [25(OH)D] concentrations were prospectively and independently associated with cardiovascular disease (CVD), cancer, and all-cause mortality in postmenopausal women. DESIGN: A substudy in 2429 postmenopausal women within the Women's Health Initiative (WHI) with measured baseline 25(OH)D concentrations were followed for 10 y for death from CVD, cancer, and all-cause mortality. Proportional hazards models were performed to evaluate quartiles of month-adjusted 25(OH)D concentrations, with adjustment for potential confounders. Sequential model building and analysis for multiplicative interaction were performed to evaluate the effects of central adiposity on the association of low 25(OH)D with all-cause mortality. RESULTS: Of the 2429 women, 224 deaths occurred, with 79 deaths from CVD and 62 deaths from cancer. Multivariate-adjusted HRs that compared quartiles 1 (lowest) to 4 (highest) of 25(OH)D for all-cause mortality (HR: 1.25; 95% CI: 0.80, 1.95), CVD mortality (HR: 1.27; 95% CI: 0.81, 1.99), and cancer mortality (HR: 1.39; 95% CI: 0.88, 2.19) were not significant. There was a potential interaction (P = 0.08) between abdominal obesity and low 25(OH)D concentrations that showed an increased risk of the lowest quartile of 25(OH)D concentrations (HR: 1.85; 95% CI: 1.00, 3.44) with increased mortality in women with a normal waist circumference but no increased risk in women with abdominal obesity (HR: 0.96; 95% CI: 0.52, 1.76). CONCLUSION: Body fat distribution may play an important role in the modulation of the effect of low vitamin D concentrations on health. This trial was registered at clinicaltrials.gov as NCT 00000611. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/22030222/Prospective_association_of_vitamin_D_concentrations_with_mortality_in_postmenopausal_women:_results_from_the_Women's_Health_Initiative__WHI__ DB - PRIME DP - Unbound Medicine ER -