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Diets high in palmitic acid (16:0), lauric and myristic acids (12:0 + 14:0), or oleic acid (18:1) do not alter postprandial or fasting plasma homocysteine and inflammatory markers in healthy Malaysian adults.
Am J Clin Nutr. 2011 Dec; 94(6):1451-7.AJ

Abstract

BACKGROUND

Dietary fat type is known to modulate the plasma lipid profile, but its effects on plasma homocysteine and inflammatory markers are unclear.

OBJECTIVE

We investigated the effects of high-protein Malaysian diets prepared with palm olein, coconut oil (CO), or virgin olive oil on plasma homocysteine and selected markers of inflammation and cardiovascular disease (CVD) in healthy adults.

DESIGN

A randomized-crossover intervention with 3 dietary sequences of 5 wk each was conducted in 45 healthy subjects. The 3 test fats, namely palmitic acid (16:0)-rich palm olein (PO), lauric and myristic acid (12:0 + 14:0)-rich CO, and oleic acid (18:1)-rich virgin olive oil (OO), were incorporated at two-thirds of 30% fat calories into high-protein Malaysian diets.

RESULTS

No significant differences were observed in the effects of the 3 diets on plasma total homocysteine (tHcy) and the inflammatory markers TNF-α, IL-1β, IL-6, and IL-8, high-sensitivity C-reactive protein, and interferon-γ. Diets prepared with PO and OO had comparable nonhypercholesterolemic effects; the postprandial total cholesterol for both diets and all fasting lipid indexes for the OO diet were significantly lower (P < 0.05) than for the CO diet. Unlike the PO and OO diets, the CO diet was shown to decrease postprandial lipoprotein(a).

CONCLUSION

Diets that were rich in saturated fatty acids prepared with either PO or CO, and an OO diet that was high in oleic acid, did not alter postprandial or fasting plasma concentrations of tHcy and selected inflammatory markers. This trial was registered at clinicaltrials.gov as NCT00941837.

Authors+Show Affiliations

Department of Nutrition and Dietetics, International Medical University, Kuala Lumpur, Malaysia. ph080925907@imu.edu.myNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22030224

Citation

Voon, Phooi Tee, et al. "Diets High in Palmitic Acid (16:0), Lauric and Myristic Acids (12:0 + 14:0), or Oleic Acid (18:1) Do Not Alter Postprandial or Fasting Plasma Homocysteine and Inflammatory Markers in Healthy Malaysian Adults." The American Journal of Clinical Nutrition, vol. 94, no. 6, 2011, pp. 1451-7.
Voon PT, Ng TK, Lee VK, et al. Diets high in palmitic acid (16:0), lauric and myristic acids (12:0 + 14:0), or oleic acid (18:1) do not alter postprandial or fasting plasma homocysteine and inflammatory markers in healthy Malaysian adults. Am J Clin Nutr. 2011;94(6):1451-7.
Voon, P. T., Ng, T. K., Lee, V. K., & Nesaretnam, K. (2011). Diets high in palmitic acid (16:0), lauric and myristic acids (12:0 + 14:0), or oleic acid (18:1) do not alter postprandial or fasting plasma homocysteine and inflammatory markers in healthy Malaysian adults. The American Journal of Clinical Nutrition, 94(6), 1451-7. https://doi.org/10.3945/ajcn.111.020107
Voon PT, et al. Diets High in Palmitic Acid (16:0), Lauric and Myristic Acids (12:0 + 14:0), or Oleic Acid (18:1) Do Not Alter Postprandial or Fasting Plasma Homocysteine and Inflammatory Markers in Healthy Malaysian Adults. Am J Clin Nutr. 2011;94(6):1451-7. PubMed PMID: 22030224.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diets high in palmitic acid (16:0), lauric and myristic acids (12:0 + 14:0), or oleic acid (18:1) do not alter postprandial or fasting plasma homocysteine and inflammatory markers in healthy Malaysian adults. AU - Voon,Phooi Tee, AU - Ng,Tony Kock Wai, AU - Lee,Verna Kar Mun, AU - Nesaretnam,Kalanithi, Y1 - 2011/10/26/ PY - 2011/10/28/entrez PY - 2011/10/28/pubmed PY - 2012/2/4/medline SP - 1451 EP - 7 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 94 IS - 6 N2 - BACKGROUND: Dietary fat type is known to modulate the plasma lipid profile, but its effects on plasma homocysteine and inflammatory markers are unclear. OBJECTIVE: We investigated the effects of high-protein Malaysian diets prepared with palm olein, coconut oil (CO), or virgin olive oil on plasma homocysteine and selected markers of inflammation and cardiovascular disease (CVD) in healthy adults. DESIGN: A randomized-crossover intervention with 3 dietary sequences of 5 wk each was conducted in 45 healthy subjects. The 3 test fats, namely palmitic acid (16:0)-rich palm olein (PO), lauric and myristic acid (12:0 + 14:0)-rich CO, and oleic acid (18:1)-rich virgin olive oil (OO), were incorporated at two-thirds of 30% fat calories into high-protein Malaysian diets. RESULTS: No significant differences were observed in the effects of the 3 diets on plasma total homocysteine (tHcy) and the inflammatory markers TNF-α, IL-1β, IL-6, and IL-8, high-sensitivity C-reactive protein, and interferon-γ. Diets prepared with PO and OO had comparable nonhypercholesterolemic effects; the postprandial total cholesterol for both diets and all fasting lipid indexes for the OO diet were significantly lower (P < 0.05) than for the CO diet. Unlike the PO and OO diets, the CO diet was shown to decrease postprandial lipoprotein(a). CONCLUSION: Diets that were rich in saturated fatty acids prepared with either PO or CO, and an OO diet that was high in oleic acid, did not alter postprandial or fasting plasma concentrations of tHcy and selected inflammatory markers. This trial was registered at clinicaltrials.gov as NCT00941837. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/22030224/Diets_high_in_palmitic_acid__16:0__lauric_and_myristic_acids__12:0_+_14:0__or_oleic_acid__18:1__do_not_alter_postprandial_or_fasting_plasma_homocysteine_and_inflammatory_markers_in_healthy_Malaysian_adults_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.111.020107 DB - PRIME DP - Unbound Medicine ER -