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[Chemical constituents from the roots of Pithecellobium lucidum and their cytotoxic activity].
Zhongguo Zhong Yao Za Zhi. 2011 Jul; 36(13):1769-71.ZZ

Abstract

Six compounds were isolated from the roots of Pithecellobium lucidum by various chromatograhic techniques such as column chromatography on silica gel and Sephadex LH-20, and preparative HPLC, and their structures were elucidated as julibroside A2 (1), 3-[ (2-acetamido-2-deoxy-beta-D-glucopyranosyl) oxy] -16alpha-hydroxyolean-12-en-28-oic acid (2), galloyl acid (3), ethyl gallate (4), (+)-catechin (5), (-)-gallocatechin gallate (6) on the basis of spectrascopic data analysis. Compounds 1-6 were isolated from Pithecellobium lucidum for the first time. Compound 2 showed selective cytoxic activity against the human cell lines A2780 with an IC50 value of 1.72 micromol x L(-1).

Authors+Show Affiliations

Ma S
Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Beijing 100050, China.
Lv H
No affiliation info available
Ding G
No affiliation info available
Yu S
No affiliation info available
Chen X
No affiliation info available

MeSH

CatechinCell LineFabaceaeGallic AcidHumansInhibitory Concentration 50Oleanolic AcidPlant ExtractsPlant RootsPlants, MedicinalSaponinsTriterpenes

Pub Type(s)

Journal Article

Language

chi

PubMed ID

22032141

Citation

Ma, Shuanggang, et al. "[Chemical Constituents From the Roots of Pithecellobium Lucidum and Their Cytotoxic Activity]." Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica, vol. 36, no. 13, 2011, pp. 1769-71.
Ma S, Lv H, Ding G, et al. [Chemical constituents from the roots of Pithecellobium lucidum and their cytotoxic activity]. Zhongguo Zhong Yao Za Zhi. 2011;36(13):1769-71.
Ma, S., Lv, H., Ding, G., Yu, S., & Chen, X. (2011). [Chemical constituents from the roots of Pithecellobium lucidum and their cytotoxic activity]. Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica, 36(13), 1769-71.
Ma S, et al. [Chemical Constituents From the Roots of Pithecellobium Lucidum and Their Cytotoxic Activity]. Zhongguo Zhong Yao Za Zhi. 2011;36(13):1769-71. PubMed PMID: 22032141.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Chemical constituents from the roots of Pithecellobium lucidum and their cytotoxic activity]. AU - Ma,Shuanggang, AU - Lv,Haining, AU - Ding,Guangzhi, AU - Yu,Shishan, AU - Chen,Xiaoguang, PY - 2011/10/29/entrez PY - 2011/10/29/pubmed PY - 2013/12/24/medline SP - 1769 EP - 71 JF - Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica JO - Zhongguo Zhong Yao Za Zhi VL - 36 IS - 13 N2 - Six compounds were isolated from the roots of Pithecellobium lucidum by various chromatograhic techniques such as column chromatography on silica gel and Sephadex LH-20, and preparative HPLC, and their structures were elucidated as julibroside A2 (1), 3-[ (2-acetamido-2-deoxy-beta-D-glucopyranosyl) oxy] -16alpha-hydroxyolean-12-en-28-oic acid (2), galloyl acid (3), ethyl gallate (4), (+)-catechin (5), (-)-gallocatechin gallate (6) on the basis of spectrascopic data analysis. Compounds 1-6 were isolated from Pithecellobium lucidum for the first time. Compound 2 showed selective cytoxic activity against the human cell lines A2780 with an IC50 value of 1.72 micromol x L(-1). SN - 1001-5302 UR - https://www.unboundmedicine.com/medline/citation/22032141/[Chemical_constituents_from_the_roots_of_Pithecellobium_lucidum_and_their_cytotoxic_activity]_ DB - PRIME DP - Unbound Medicine ER -