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Oxidation of trimethoprim by ferrate(VI): kinetics, products, and antibacterial activity.
Environ Sci Technol. 2011 Dec 15; 45(24):10575-81.ES

Abstract

Kinetics, stoichiometry, and products of the oxidation of trimethoprim (TMP), one of the most commonly detected antibacterial agents in surface waters and municipal wastewaters, by ferrate(VI) (Fe(VI)) were determined. The pH dependent second-order rate constants of the reactions of Fe(VI) with TMP were examined using acid-base properties of Fe(VI) and TMP. The kinetics of reactions of diaminopyrimidine (DAP) and trimethoxytoluene (TMT) with Fe(VI) were also determined to understand the reactivity of Fe(VI) with TMP. Oxidation products of the reactions of Fe(VI) with TMP and DAP were identified by liquid chromatography-tandem mass spectrometry (LC-MS/MS). Reaction pathways of oxidation of TMP by Fe(VI) are proposed to demonstrate the cleavage of the TMP molecule to ultimately result in 3,4,5,-trimethoxybenzaldehyde and 2,4-dinitropyrimidine as among the final identified products. The oxidized products mixture exhibited no antibacterial activity against E. coli after complete consumption of TMP. Removal of TMP in the secondary effluent by Fe(VI) was achieved.

Authors+Show Affiliations

Chemistry Department, Florida Institute of Technology, 150 West University Boulevard, Melbourne, Florida 32901, United States.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22032699

Citation

Anquandah, George A K., et al. "Oxidation of Trimethoprim By ferrate(VI): Kinetics, Products, and Antibacterial Activity." Environmental Science & Technology, vol. 45, no. 24, 2011, pp. 10575-81.
Anquandah GA, Sharma VK, Knight DA, et al. Oxidation of trimethoprim by ferrate(VI): kinetics, products, and antibacterial activity. Environ Sci Technol. 2011;45(24):10575-81.
Anquandah, G. A., Sharma, V. K., Knight, D. A., Batchu, S. R., & Gardinali, P. R. (2011). Oxidation of trimethoprim by ferrate(VI): kinetics, products, and antibacterial activity. Environmental Science & Technology, 45(24), 10575-81. https://doi.org/10.1021/es202237g
Anquandah GA, et al. Oxidation of Trimethoprim By ferrate(VI): Kinetics, Products, and Antibacterial Activity. Environ Sci Technol. 2011 Dec 15;45(24):10575-81. PubMed PMID: 22032699.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oxidation of trimethoprim by ferrate(VI): kinetics, products, and antibacterial activity. AU - Anquandah,George A K, AU - Sharma,Virender K, AU - Knight,D Andrew, AU - Batchu,Sudha Rani, AU - Gardinali,Piero R, Y1 - 2011/11/23/ PY - 2011/10/29/entrez PY - 2011/10/29/pubmed PY - 2012/4/10/medline SP - 10575 EP - 81 JF - Environmental science & technology JO - Environ Sci Technol VL - 45 IS - 24 N2 - Kinetics, stoichiometry, and products of the oxidation of trimethoprim (TMP), one of the most commonly detected antibacterial agents in surface waters and municipal wastewaters, by ferrate(VI) (Fe(VI)) were determined. The pH dependent second-order rate constants of the reactions of Fe(VI) with TMP were examined using acid-base properties of Fe(VI) and TMP. The kinetics of reactions of diaminopyrimidine (DAP) and trimethoxytoluene (TMT) with Fe(VI) were also determined to understand the reactivity of Fe(VI) with TMP. Oxidation products of the reactions of Fe(VI) with TMP and DAP were identified by liquid chromatography-tandem mass spectrometry (LC-MS/MS). Reaction pathways of oxidation of TMP by Fe(VI) are proposed to demonstrate the cleavage of the TMP molecule to ultimately result in 3,4,5,-trimethoxybenzaldehyde and 2,4-dinitropyrimidine as among the final identified products. The oxidized products mixture exhibited no antibacterial activity against E. coli after complete consumption of TMP. Removal of TMP in the secondary effluent by Fe(VI) was achieved. SN - 1520-5851 UR - https://www.unboundmedicine.com/medline/citation/22032699/Oxidation_of_trimethoprim_by_ferrate_VI_:_kinetics_products_and_antibacterial_activity_ L2 - https://doi.org/10.1021/es202237g DB - PRIME DP - Unbound Medicine ER -