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Incidence, morbidity, and mortality of contrast-induced acute kidney injury in a surgical intensive care unit: a prospective cohort study.
J Crit Care 2012; 27(3):322.e1-5JC

Abstract

PURPOSE

Data on contrast-induced acute kidney injury (CI-AKI) in intensive care unit (ICU) are scarce and controversial. The objectives of the study were to evaluate the incidence and characteristics of CI-AKI in a surgical ICU.

MATERIALS AND METHODS

We conducted a 13-month prospective observational study. Three definitions were compared to characterize CI-AKI: Barrett and Parfrey criteria; Risk of renal dysfunction, Injury to the kidney, Failure of kidney function, Loss of kidney function and End stage renal disease (RIFLE) classification; and Acute Kidney Injury Network (AKIN) criteria. Patients hospitalized in surgical ICU who had received an injection of contrast medium, who were not on renal replacement therapy, who had stable serum creatinine before injection, and no other etiology for new acute kidney injury were included.

RESULTS

One hundred one patients were included. The frequency of CI-AKI was 17%, 19%, and 19% according to Barrett and Parfrey criteria; RIFLE classification; and AKIN criteria, respectively. Diabetes mellitus, creatinine clearance less than 60 mL/min, and concomitant aminoglycoside administration were associated with CI-AKI. Statistically significant associations were found between CI-AKI and renal replacement therapy with all 3 definitions and between CI-AKI and mortality when AKIN criteria were used.

CONCLUSIONS

These results show that CI-AKI is not inconsequential in critically ill patients. In the present study, AKIN criteria appear to be most relevant to define CI-AKI. Further studies are required to explore CI-AKI prevention in ICU.

Authors+Show Affiliations

Anesthesia and surgical intensive care medicine, University hospital, Caen, France. valette-x@chu-caen.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22033061

Citation

Valette, Xavier, et al. "Incidence, Morbidity, and Mortality of Contrast-induced Acute Kidney Injury in a Surgical Intensive Care Unit: a Prospective Cohort Study." Journal of Critical Care, vol. 27, no. 3, 2012, pp. 322.e1-5.
Valette X, Parienti JJ, Plaud B, et al. Incidence, morbidity, and mortality of contrast-induced acute kidney injury in a surgical intensive care unit: a prospective cohort study. J Crit Care. 2012;27(3):322.e1-5.
Valette, X., Parienti, J. J., Plaud, B., Lehoux, P., Samba, D., & Hanouz, J. L. (2012). Incidence, morbidity, and mortality of contrast-induced acute kidney injury in a surgical intensive care unit: a prospective cohort study. Journal of Critical Care, 27(3), pp. 322.e1-5. doi:10.1016/j.jcrc.2011.08.005.
Valette X, et al. Incidence, Morbidity, and Mortality of Contrast-induced Acute Kidney Injury in a Surgical Intensive Care Unit: a Prospective Cohort Study. J Crit Care. 2012;27(3):322.e1-5. PubMed PMID: 22033061.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Incidence, morbidity, and mortality of contrast-induced acute kidney injury in a surgical intensive care unit: a prospective cohort study. AU - Valette,Xavier, AU - Parienti,Jean-Jacques, AU - Plaud,Benoit, AU - Lehoux,Philippe, AU - Samba,Désiré, AU - Hanouz,Jean-Luc, Y1 - 2011/10/26/ PY - 2011/04/11/received PY - 2011/07/05/revised PY - 2011/08/09/accepted PY - 2011/10/29/entrez PY - 2011/10/29/pubmed PY - 2012/10/2/medline SP - 322.e1 EP - 5 JF - Journal of critical care JO - J Crit Care VL - 27 IS - 3 N2 - PURPOSE: Data on contrast-induced acute kidney injury (CI-AKI) in intensive care unit (ICU) are scarce and controversial. The objectives of the study were to evaluate the incidence and characteristics of CI-AKI in a surgical ICU. MATERIALS AND METHODS: We conducted a 13-month prospective observational study. Three definitions were compared to characterize CI-AKI: Barrett and Parfrey criteria; Risk of renal dysfunction, Injury to the kidney, Failure of kidney function, Loss of kidney function and End stage renal disease (RIFLE) classification; and Acute Kidney Injury Network (AKIN) criteria. Patients hospitalized in surgical ICU who had received an injection of contrast medium, who were not on renal replacement therapy, who had stable serum creatinine before injection, and no other etiology for new acute kidney injury were included. RESULTS: One hundred one patients were included. The frequency of CI-AKI was 17%, 19%, and 19% according to Barrett and Parfrey criteria; RIFLE classification; and AKIN criteria, respectively. Diabetes mellitus, creatinine clearance less than 60 mL/min, and concomitant aminoglycoside administration were associated with CI-AKI. Statistically significant associations were found between CI-AKI and renal replacement therapy with all 3 definitions and between CI-AKI and mortality when AKIN criteria were used. CONCLUSIONS: These results show that CI-AKI is not inconsequential in critically ill patients. In the present study, AKIN criteria appear to be most relevant to define CI-AKI. Further studies are required to explore CI-AKI prevention in ICU. SN - 1557-8615 UR - https://www.unboundmedicine.com/medline/citation/22033061/Incidence_morbidity_and_mortality_of_contrast_induced_acute_kidney_injury_in_a_surgical_intensive_care_unit:_a_prospective_cohort_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0883-9441(11)00381-9 DB - PRIME DP - Unbound Medicine ER -