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Protective effect of Emblica officinalis (amla) on isoproterenol-induced cardiotoxicity in rats.
Toxicol Ind Health. 2012 Jun; 28(5):399-411.TI

Abstract

Emblica officinalis, commonly known as amla, is an important medicinal plant reputed for its dietary and therapeutic uses. The aim of the present study was to investigate the protective role of E. officinalis against isoproterenol (ISP)-induced cardiotoxicity in rats and elucidate the possible mechanism involved. Rats were administered E. officinalis (100, 250 and 500 mg/kg, p.o.) or vehicle (normal saline) for 30 days, with concurrent subcutaneous injections of ISP (85 mg/kg, at 24 h interval) on 29th and 30th day. ISP-induced cardiac dysfunction as evidenced by decreased mean arterial pressure, heart rate, contractility (+LVdP/dt) and relaxation (-LVdP/dt) along with increased left ventricular end diastolic pressure. ISP significantly (p < 0.05) decreased antioxidant enzymes, superoxide dismutase, catalase and glutathione peroxidase and myocyte-injury-specific marker enzymes, creatine phosphokinase-MB and lactate dehydrogenase in heart. A significant (p < 0.05) depletion of reduced glutathione and increase in thiobarbituric acid reactive substances along with histopathological alteration has further indicated the oxidative damage of myocardium. However, pretreatment with E. officinalis exhibited restoration of hemodynamic and left ventricular function along with significant preservation of antioxidants, myocytes-injury-specific marker enzymes and significant inhibition of lipid peroxidation. Furthermore, histopathological salvage of myocardium reconfirmed the protective effects of E. officinalis. Results of the present study demonstrate cardioprotective potential of E. officinalis attributed to its potent antioxidant and free radical scavenging activity as evidenced by favorable improvement in hemodynamic, contractile function and tissue antioxidant status.

Authors+Show Affiliations

Department of Pharmacology, All India Institute of Medical Sciences, New Delhi, India.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22033422

Citation

Ojha, Shreesh, et al. "Protective Effect of Emblica Officinalis (amla) On Isoproterenol-induced Cardiotoxicity in Rats." Toxicology and Industrial Health, vol. 28, no. 5, 2012, pp. 399-411.
Ojha S, Golechha M, Kumari S, et al. Protective effect of Emblica officinalis (amla) on isoproterenol-induced cardiotoxicity in rats. Toxicol Ind Health. 2012;28(5):399-411.
Ojha, S., Golechha, M., Kumari, S., & Arya, D. S. (2012). Protective effect of Emblica officinalis (amla) on isoproterenol-induced cardiotoxicity in rats. Toxicology and Industrial Health, 28(5), 399-411. https://doi.org/10.1177/0748233711413798
Ojha S, et al. Protective Effect of Emblica Officinalis (amla) On Isoproterenol-induced Cardiotoxicity in Rats. Toxicol Ind Health. 2012;28(5):399-411. PubMed PMID: 22033422.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protective effect of Emblica officinalis (amla) on isoproterenol-induced cardiotoxicity in rats. AU - Ojha,Shreesh, AU - Golechha,Mahaveer, AU - Kumari,Santosh, AU - Arya,Dharamvir Singh, Y1 - 2011/10/27/ PY - 2011/10/29/entrez PY - 2011/10/29/pubmed PY - 2012/12/15/medline SP - 399 EP - 411 JF - Toxicology and industrial health JO - Toxicol Ind Health VL - 28 IS - 5 N2 - Emblica officinalis, commonly known as amla, is an important medicinal plant reputed for its dietary and therapeutic uses. The aim of the present study was to investigate the protective role of E. officinalis against isoproterenol (ISP)-induced cardiotoxicity in rats and elucidate the possible mechanism involved. Rats were administered E. officinalis (100, 250 and 500 mg/kg, p.o.) or vehicle (normal saline) for 30 days, with concurrent subcutaneous injections of ISP (85 mg/kg, at 24 h interval) on 29th and 30th day. ISP-induced cardiac dysfunction as evidenced by decreased mean arterial pressure, heart rate, contractility (+LVdP/dt) and relaxation (-LVdP/dt) along with increased left ventricular end diastolic pressure. ISP significantly (p < 0.05) decreased antioxidant enzymes, superoxide dismutase, catalase and glutathione peroxidase and myocyte-injury-specific marker enzymes, creatine phosphokinase-MB and lactate dehydrogenase in heart. A significant (p < 0.05) depletion of reduced glutathione and increase in thiobarbituric acid reactive substances along with histopathological alteration has further indicated the oxidative damage of myocardium. However, pretreatment with E. officinalis exhibited restoration of hemodynamic and left ventricular function along with significant preservation of antioxidants, myocytes-injury-specific marker enzymes and significant inhibition of lipid peroxidation. Furthermore, histopathological salvage of myocardium reconfirmed the protective effects of E. officinalis. Results of the present study demonstrate cardioprotective potential of E. officinalis attributed to its potent antioxidant and free radical scavenging activity as evidenced by favorable improvement in hemodynamic, contractile function and tissue antioxidant status. SN - 1477-0393 UR - https://www.unboundmedicine.com/medline/citation/22033422/Protective_effect_of_Emblica_officinalis__amla__on_isoproterenol_induced_cardiotoxicity_in_rats_ L2 - https://journals.sagepub.com/doi/10.1177/0748233711413798?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -