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A new contrast in MR mammography by means of chemical exchange saturation transfer (CEST) imaging at 3 Tesla: preliminary results.
Rofo. 2011 Nov; 183(11):1030-6.ROFO

Abstract

PURPOSE

To evaluate the feasibility to detect and delineate malignant breast lesions in human patients by chemical exchange saturation transfer (CEST) as an MR imaging technique without the need for contrast agent administration.

MATERIALS AND METHODS

Six female patients referred for pre-surgical staging due to histologically confirmed breast cancer were examined with MR at 3 T. The routine breast protocol included T (2w), STIR, T (1w)-DCE and contrast-enhanced T (1w) imaging with SPAIR fat suppression. For CEST imaging, a 3D RF-spoiled gradient echo (GRE) sequence with an optimized saturation pulse train was applied. To assess the diagnostic value of the technique, CEST effects observed between frequency offsets of 1.2 to 1.8 ppm from the bulk water resonance were compared to pharmacokinetic parameter maps (k (ep)) obtained by DCE-MRI.

RESULTS

In 3 of 6 patients, regions with high CEST signal intensity correlated well with tumor areas as determined by DCE-MRI. Analysis of signal intensities from ROIs in tumor, fibroglandular, adipose, and muscle tissue revealed significantly higher CEST values in tumor tissue compared to fibroglandular tissue. The detection of lesions was equally well possible with DCE-MRI and CEST-MRI. In the three other patients, the tumor regions could not be delineated based on the CEST image due to artifacts, which were most likely caused by a high content of fat tissue within the ROIs.

CONCLUSION

The results of this initial feasibility study indicate a significant potential of CEST-MRI to discriminate cancer from fibroglandular tissue in the human breast by a CEST contrast generated by endogenous solute molecules.

Authors+Show Affiliations

Center for High Field MR, Medical University of Vienna.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Comparative Study
Evaluation Study
Journal Article

Language

eng

PubMed ID

22034086

Citation

Schmitt, B, et al. "A New Contrast in MR Mammography By Means of Chemical Exchange Saturation Transfer (CEST) Imaging at 3 Tesla: Preliminary Results." RoFo : Fortschritte Auf Dem Gebiete Der Rontgenstrahlen Und Der Nuklearmedizin, vol. 183, no. 11, 2011, pp. 1030-6.
Schmitt B, Zamecnik P, Zaiss M, et al. A new contrast in MR mammography by means of chemical exchange saturation transfer (CEST) imaging at 3 Tesla: preliminary results. Rofo. 2011;183(11):1030-6.
Schmitt, B., Zamecnik, P., Zaiss, M., Rerich, E., Schuster, L., Bachert, P., & Schlemmer, H. P. (2011). A new contrast in MR mammography by means of chemical exchange saturation transfer (CEST) imaging at 3 Tesla: preliminary results. RoFo : Fortschritte Auf Dem Gebiete Der Rontgenstrahlen Und Der Nuklearmedizin, 183(11), 1030-6. https://doi.org/10.1055/s-0031-1281764
Schmitt B, et al. A New Contrast in MR Mammography By Means of Chemical Exchange Saturation Transfer (CEST) Imaging at 3 Tesla: Preliminary Results. Rofo. 2011;183(11):1030-6. PubMed PMID: 22034086.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A new contrast in MR mammography by means of chemical exchange saturation transfer (CEST) imaging at 3 Tesla: preliminary results. AU - Schmitt,B, AU - Zamecnik,P, AU - Zaiss,M, AU - Rerich,E, AU - Schuster,L, AU - Bachert,P, AU - Schlemmer,H P, Y1 - 2011/10/27/ PY - 2011/10/29/entrez PY - 2011/10/29/pubmed PY - 2011/12/14/medline SP - 1030 EP - 6 JF - RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin JO - Rofo VL - 183 IS - 11 N2 - PURPOSE: To evaluate the feasibility to detect and delineate malignant breast lesions in human patients by chemical exchange saturation transfer (CEST) as an MR imaging technique without the need for contrast agent administration. MATERIALS AND METHODS: Six female patients referred for pre-surgical staging due to histologically confirmed breast cancer were examined with MR at 3 T. The routine breast protocol included T (2w), STIR, T (1w)-DCE and contrast-enhanced T (1w) imaging with SPAIR fat suppression. For CEST imaging, a 3D RF-spoiled gradient echo (GRE) sequence with an optimized saturation pulse train was applied. To assess the diagnostic value of the technique, CEST effects observed between frequency offsets of 1.2 to 1.8 ppm from the bulk water resonance were compared to pharmacokinetic parameter maps (k (ep)) obtained by DCE-MRI. RESULTS: In 3 of 6 patients, regions with high CEST signal intensity correlated well with tumor areas as determined by DCE-MRI. Analysis of signal intensities from ROIs in tumor, fibroglandular, adipose, and muscle tissue revealed significantly higher CEST values in tumor tissue compared to fibroglandular tissue. The detection of lesions was equally well possible with DCE-MRI and CEST-MRI. In the three other patients, the tumor regions could not be delineated based on the CEST image due to artifacts, which were most likely caused by a high content of fat tissue within the ROIs. CONCLUSION: The results of this initial feasibility study indicate a significant potential of CEST-MRI to discriminate cancer from fibroglandular tissue in the human breast by a CEST contrast generated by endogenous solute molecules. SN - 1438-9010 UR - https://www.unboundmedicine.com/medline/citation/22034086/A_new_contrast_in_MR_mammography_by_means_of_chemical_exchange_saturation_transfer__CEST__imaging_at_3_Tesla:_preliminary_results_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-0031-1281764 DB - PRIME DP - Unbound Medicine ER -