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Korean red ginseng (Panax ginseng) improves insulin sensitivity in high fat fed Sprague-Dawley rats.
Phytother Res. 2012 Jan; 26(1):142-7.PR

Abstract

Many studies have documented that ginseng has antidiabetic and antiobesity effects, but the mechanism of the effects has not been elucidated. The aim of this study was to determine the effect of Korean red ginseng (KRG, Panax ginseng) and investigate the mechanism of antidiabetic and antiobesity effects in obese insulin resistant animal models. Sprague-Dawley (SD) rats were divided into three groups: a control group (group I) fed a normal diet, another group (group II) fed only high fat diet (HFD) and a third group (group III) fed HFD with KRG (200 mg/kg, oral) for 18 weeks. The body weight, food intake, adipose tissues, liver, kidney, pancreas, adiponectin, and leptin were measured. Blood glucose, insulin tolerance test, and hyperinsulinemic euglycemic clamp test were investigated. A significant weight reduction, especially fat mass reduction, was observed in the KRG treated group. Increased insulin sensitivity was found in the KRG treated group. We observed increased insulin signalling, increased phosphorylation of IR, IRS-1, Akt, and membranous GLUT4 in muscle by Western blotting assay. In conclusion, KRG may have antidiabetic and antiobesity effects due to partly increased insulin sensitivity by increased adipokine and partly enhanced insulin signalling.

Authors+Show Affiliations

Department of Internal Medicine, Yonsei University College of Medicine, Seoul 120-752, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22034219

Citation

Lee, Seo Hee, et al. "Korean Red Ginseng (Panax Ginseng) Improves Insulin Sensitivity in High Fat Fed Sprague-Dawley Rats." Phytotherapy Research : PTR, vol. 26, no. 1, 2012, pp. 142-7.
Lee SH, Lee HJ, Lee YH, et al. Korean red ginseng (Panax ginseng) improves insulin sensitivity in high fat fed Sprague-Dawley rats. Phytother Res. 2012;26(1):142-7.
Lee, S. H., Lee, H. J., Lee, Y. H., Lee, B. W., Cha, B. S., Kang, E. S., Ahn, C. W., Park, J. S., Kim, H. J., Lee, E. Y., & Lee, H. C. (2012). Korean red ginseng (Panax ginseng) improves insulin sensitivity in high fat fed Sprague-Dawley rats. Phytotherapy Research : PTR, 26(1), 142-7. https://doi.org/10.1002/ptr.3610
Lee SH, et al. Korean Red Ginseng (Panax Ginseng) Improves Insulin Sensitivity in High Fat Fed Sprague-Dawley Rats. Phytother Res. 2012;26(1):142-7. PubMed PMID: 22034219.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Korean red ginseng (Panax ginseng) improves insulin sensitivity in high fat fed Sprague-Dawley rats. AU - Lee,Seo Hee, AU - Lee,Hyun Joo, AU - Lee,Yong-ho, AU - Lee,Byung-Wan, AU - Cha,Bong Soo, AU - Kang,Eun Seok, AU - Ahn,Chul Woo, AU - Park,Jong Sook, AU - Kim,Hyo Jeong, AU - Lee,Eun Young, AU - Lee,Hyun Chul, Y1 - 2011/10/28/ PY - 2011/03/29/received PY - 2011/06/07/revised PY - 2011/06/10/accepted PY - 2011/10/29/entrez PY - 2011/10/29/pubmed PY - 2012/6/13/medline SP - 142 EP - 7 JF - Phytotherapy research : PTR JO - Phytother Res VL - 26 IS - 1 N2 - Many studies have documented that ginseng has antidiabetic and antiobesity effects, but the mechanism of the effects has not been elucidated. The aim of this study was to determine the effect of Korean red ginseng (KRG, Panax ginseng) and investigate the mechanism of antidiabetic and antiobesity effects in obese insulin resistant animal models. Sprague-Dawley (SD) rats were divided into three groups: a control group (group I) fed a normal diet, another group (group II) fed only high fat diet (HFD) and a third group (group III) fed HFD with KRG (200 mg/kg, oral) for 18 weeks. The body weight, food intake, adipose tissues, liver, kidney, pancreas, adiponectin, and leptin were measured. Blood glucose, insulin tolerance test, and hyperinsulinemic euglycemic clamp test were investigated. A significant weight reduction, especially fat mass reduction, was observed in the KRG treated group. Increased insulin sensitivity was found in the KRG treated group. We observed increased insulin signalling, increased phosphorylation of IR, IRS-1, Akt, and membranous GLUT4 in muscle by Western blotting assay. In conclusion, KRG may have antidiabetic and antiobesity effects due to partly increased insulin sensitivity by increased adipokine and partly enhanced insulin signalling. SN - 1099-1573 UR - https://www.unboundmedicine.com/medline/citation/22034219/Korean_red_ginseng__Panax_ginseng__improves_insulin_sensitivity_in_high_fat_fed_Sprague_Dawley_rats_ L2 - https://doi.org/10.1002/ptr.3610 DB - PRIME DP - Unbound Medicine ER -