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Maternal use of folic acid supplements during pregnancy, and childhood respiratory health and atopy.
Eur Respir J. 2012 Jun; 39(6):1468-74.ER

Abstract

Previous studies have suggested possible adverse side-effects of maternal use of folic acid-containing supplements (FACSs) during pregnancy on wheeze and asthma in early childhood. We investigated the association between maternal use of FACSs and childhood respiratory health and atopy in the first 8 yrs of life. Data on maternal use of FACSs, collected during pregnancy, were available for 3,786 children participating in the Prevention and Incidence of Asthma and Mite Allergy birth cohort study. Questionnaire data on children's respiratory and allergic symptoms were collected annually and allergic sensitisation and bronchial hyperresponsiveness (BHR) were measured at 8 yrs of age. No overall (from 1 to 8 yrs of age) associations were observed between maternal use of FACSs and (frequent) asthma symptoms, wheeze, lower respiratory tract infection, frequent respiratory tract infection and eczema. Maternal folic acid use was associated with wheeze at 1 yr of age (prevalence ratio 1.20, 95% CI 1.04-1.39), but not with wheeze at later ages. Pre-natal exposure to FACSs was not associated with sensitisation and BHR. Apart from a small increased risk of early wheeze, we observed no adverse respiratory or allergic outcomes associated with pre-natal FACSs exposure in our study population.

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Authors+Show Affiliations

Bekkers MB
Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands. marga.bekkers@rivm.nl
Elstgeest LE
No affiliation info available
Scholtens S
No affiliation info available
Haveman-Nies A
No affiliation info available
de Jongste JC
No affiliation info available
Kerkhof M
No affiliation info available
Koppelman GH
No affiliation info available
Gehring U
No affiliation info available
Smit HA
No affiliation info available
Wijga AH
No affiliation info available

MeSH

AdultAsthmaBronchial HyperreactivityChildChild, PreschoolCohort StudiesDietary SupplementsEczemaFemaleFolic AcidHealth SurveysHumansHypersensitivityIncidenceInfantMaleMaternal-Fetal ExchangePregnancyPrenatal Exposure Delayed EffectsPrevalenceRespiratory SoundsRespiratory Tract InfectionsSurveys and QuestionnairesVitamin B Complex

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22034647

Citation

Bekkers, Marga B M., et al. "Maternal Use of Folic Acid Supplements During Pregnancy, and Childhood Respiratory Health and Atopy." The European Respiratory Journal, vol. 39, no. 6, 2012, pp. 1468-74.
Bekkers MB, Elstgeest LE, Scholtens S, et al. Maternal use of folic acid supplements during pregnancy, and childhood respiratory health and atopy. Eur Respir J. 2012;39(6):1468-74.
Bekkers, M. B., Elstgeest, L. E., Scholtens, S., Haveman-Nies, A., de Jongste, J. C., Kerkhof, M., Koppelman, G. H., Gehring, U., Smit, H. A., & Wijga, A. H. (2012). Maternal use of folic acid supplements during pregnancy, and childhood respiratory health and atopy. The European Respiratory Journal, 39(6), 1468-74. https://doi.org/10.1183/09031936.00094511
Bekkers MB, et al. Maternal Use of Folic Acid Supplements During Pregnancy, and Childhood Respiratory Health and Atopy. Eur Respir J. 2012;39(6):1468-74. PubMed PMID: 22034647.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Maternal use of folic acid supplements during pregnancy, and childhood respiratory health and atopy. AU - Bekkers,Marga B M, AU - Elstgeest,Liset E M, AU - Scholtens,Salome, AU - Haveman-Nies,Annemien, AU - de Jongste,Johan C, AU - Kerkhof,Marjan, AU - Koppelman,Gerard H, AU - Gehring,Ulrike, AU - Smit,Henriëtte A, AU - Wijga,Alet H, Y1 - 2011/10/27/ PY - 2011/10/29/entrez PY - 2011/10/29/pubmed PY - 2012/10/17/medline SP - 1468 EP - 74 JF - The European respiratory journal JO - Eur Respir J VL - 39 IS - 6 N2 - Previous studies have suggested possible adverse side-effects of maternal use of folic acid-containing supplements (FACSs) during pregnancy on wheeze and asthma in early childhood. We investigated the association between maternal use of FACSs and childhood respiratory health and atopy in the first 8 yrs of life. Data on maternal use of FACSs, collected during pregnancy, were available for 3,786 children participating in the Prevention and Incidence of Asthma and Mite Allergy birth cohort study. Questionnaire data on children's respiratory and allergic symptoms were collected annually and allergic sensitisation and bronchial hyperresponsiveness (BHR) were measured at 8 yrs of age. No overall (from 1 to 8 yrs of age) associations were observed between maternal use of FACSs and (frequent) asthma symptoms, wheeze, lower respiratory tract infection, frequent respiratory tract infection and eczema. Maternal folic acid use was associated with wheeze at 1 yr of age (prevalence ratio 1.20, 95% CI 1.04-1.39), but not with wheeze at later ages. Pre-natal exposure to FACSs was not associated with sensitisation and BHR. Apart from a small increased risk of early wheeze, we observed no adverse respiratory or allergic outcomes associated with pre-natal FACSs exposure in our study population. SN - 1399-3003 UR - https://www.unboundmedicine.com/medline/citation/22034647/Maternal_use_of_folic_acid_supplements_during_pregnancy_and_childhood_respiratory_health_and_atopy_ L2 - http://erj.ersjournals.com/cgi/pmidlookup?view=long&pmid=22034647 DB - PRIME DP - Unbound Medicine ER -