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Rh-catalyzed asymmetric hydroformylation of functionalized 1,1-disubstituted olefins.
J Am Chem Soc. 2011 Nov 30; 133(47):19080-3.JA

Abstract

The first method for the highly enantioselective rhodium-catalyzed hydroformylation of 1,1-disubstituted olefins has been developed. By employing either of the P-chirogenic phosphine ligands BenzP* and QuinoxP*, linear aldehydes with β-chirality can be prepared in a highly enantioselective fashion with good chemo- and regioselectivities.

Authors+Show Affiliations

Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22035143

Citation

Wang, Xiao, and Stephen L. Buchwald. "Rh-catalyzed Asymmetric Hydroformylation of Functionalized 1,1-disubstituted Olefins." Journal of the American Chemical Society, vol. 133, no. 47, 2011, pp. 19080-3.
Wang X, Buchwald SL. Rh-catalyzed asymmetric hydroformylation of functionalized 1,1-disubstituted olefins. J Am Chem Soc. 2011;133(47):19080-3.
Wang, X., & Buchwald, S. L. (2011). Rh-catalyzed asymmetric hydroformylation of functionalized 1,1-disubstituted olefins. Journal of the American Chemical Society, 133(47), 19080-3. https://doi.org/10.1021/ja2092689
Wang X, Buchwald SL. Rh-catalyzed Asymmetric Hydroformylation of Functionalized 1,1-disubstituted Olefins. J Am Chem Soc. 2011 Nov 30;133(47):19080-3. PubMed PMID: 22035143.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Rh-catalyzed asymmetric hydroformylation of functionalized 1,1-disubstituted olefins. AU - Wang,Xiao, AU - Buchwald,Stephen L, Y1 - 2011/11/07/ PY - 2011/11/1/entrez PY - 2011/11/1/pubmed PY - 2012/3/21/medline SP - 19080 EP - 3 JF - Journal of the American Chemical Society JO - J Am Chem Soc VL - 133 IS - 47 N2 - The first method for the highly enantioselective rhodium-catalyzed hydroformylation of 1,1-disubstituted olefins has been developed. By employing either of the P-chirogenic phosphine ligands BenzP* and QuinoxP*, linear aldehydes with β-chirality can be prepared in a highly enantioselective fashion with good chemo- and regioselectivities. SN - 1520-5126 UR - https://www.unboundmedicine.com/medline/citation/22035143/Rh_catalyzed_asymmetric_hydroformylation_of_functionalized_11_disubstituted_olefins_ L2 - https://doi.org/10.1021/ja2092689 DB - PRIME DP - Unbound Medicine ER -