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Daily transcranial direct current stimulation (tDCS) leads to greater increases in cortical excitability than second daily transcranial direct current stimulation.
Brain Stimul 2012; 5(3):208-213BS

Abstract

BACKGROUND

Evidence from recent clinical trials suggests that transcranial direct current stimulation (tDCS) may have potential in treating neuropsychiatric disorders. However, the optimal frequency at which tDCS sessions should be administered is unknown.

OBJECTIVE/HYPOTHESIS

This study investigated the effects of daily or second daily tDCS sessions on motor cortical excitability, over a 5-day period.

METHODS

Twelve healthy volunteers received daily or second daily sessions of tDCS to the left primary motor cortex over the study period, in a randomized, intraindividual crossover design. Motor cortical excitability was assessed before and after tDCS at each session through responses to transcranial magnetic stimulation.

RESULTS

Over a fixed 5-day period, tDCS induced greater increases in MEP amplitude when given daily rather than second daily. Analyses showed that this difference reflected greater cumulative effects between sessions rather than a greater response to each individual tDCS session.

CONCLUSIONS

These results demonstrate that in the motor cortex of healthy volunteers, tDCS alters cortical excitability more effectively when given daily rather than second daily over a 5-day period.

Authors+Show Affiliations

School of Psychiatry, University of New South Wales, Black Dog Institute, Sydney, Australia.School of Psychiatry, University of New South Wales, Black Dog Institute, Sydney, Australia.Neuroscience Research Australia, Sydney; School of Medical Sciences, University of New South Wales, Sydney, Australia.School of Psychiatry, University of New South Wales, Black Dog Institute, Sydney, Australia.School of Psychiatry, University of New South Wales, Black Dog Institute, Sydney, Australia; St. George Hospital, Sydney, Australia. Electronic address: colleen.loo@unsw.edu.au.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22037139

Citation

Alonzo, Angelo, et al. "Daily Transcranial Direct Current Stimulation (tDCS) Leads to Greater Increases in Cortical Excitability Than Second Daily Transcranial Direct Current Stimulation." Brain Stimulation, vol. 5, no. 3, 2012, pp. 208-213.
Alonzo A, Brassil J, Taylor JL, et al. Daily transcranial direct current stimulation (tDCS) leads to greater increases in cortical excitability than second daily transcranial direct current stimulation. Brain Stimul. 2012;5(3):208-213.
Alonzo, A., Brassil, J., Taylor, J. L., Martin, D., & Loo, C. K. (2012). Daily transcranial direct current stimulation (tDCS) leads to greater increases in cortical excitability than second daily transcranial direct current stimulation. Brain Stimulation, 5(3), pp. 208-213. doi:10.1016/j.brs.2011.04.006.
Alonzo A, et al. Daily Transcranial Direct Current Stimulation (tDCS) Leads to Greater Increases in Cortical Excitability Than Second Daily Transcranial Direct Current Stimulation. Brain Stimul. 2012;5(3):208-213. PubMed PMID: 22037139.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Daily transcranial direct current stimulation (tDCS) leads to greater increases in cortical excitability than second daily transcranial direct current stimulation. AU - Alonzo,Angelo, AU - Brassil,Joseph, AU - Taylor,Janet L, AU - Martin,Donel, AU - Loo,Colleen K, Y1 - 2011/05/20/ PY - 2010/12/03/received PY - 2011/04/14/revised PY - 2011/04/19/accepted PY - 2011/11/1/entrez PY - 2011/11/1/pubmed PY - 2012/12/19/medline SP - 208 EP - 213 JF - Brain stimulation JO - Brain Stimul VL - 5 IS - 3 N2 - BACKGROUND: Evidence from recent clinical trials suggests that transcranial direct current stimulation (tDCS) may have potential in treating neuropsychiatric disorders. However, the optimal frequency at which tDCS sessions should be administered is unknown. OBJECTIVE/HYPOTHESIS: This study investigated the effects of daily or second daily tDCS sessions on motor cortical excitability, over a 5-day period. METHODS: Twelve healthy volunteers received daily or second daily sessions of tDCS to the left primary motor cortex over the study period, in a randomized, intraindividual crossover design. Motor cortical excitability was assessed before and after tDCS at each session through responses to transcranial magnetic stimulation. RESULTS: Over a fixed 5-day period, tDCS induced greater increases in MEP amplitude when given daily rather than second daily. Analyses showed that this difference reflected greater cumulative effects between sessions rather than a greater response to each individual tDCS session. CONCLUSIONS: These results demonstrate that in the motor cortex of healthy volunteers, tDCS alters cortical excitability more effectively when given daily rather than second daily over a 5-day period. SN - 1876-4754 UR - https://www.unboundmedicine.com/medline/citation/22037139/Daily_transcranial_direct_current_stimulation__tDCS__leads_to_greater_increases_in_cortical_excitability_than_second_daily_transcranial_direct_current_stimulation_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1935-861X(11)00065-9 DB - PRIME DP - Unbound Medicine ER -