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Inhibition of mTOR by rapamycin in the amygdala or hippocampus impairs formation and reconsolidation of inhibitory avoidance memory.
Neurobiol Learn Mem. 2012 Jan; 97(1):105-12.NL

Abstract

Mammalian target of rapamycin (mTOR), a central regulator of protein synthesis in neurons, has been implicated in synaptic plasticity and memory. Here we show that mTOR inhibition by rapamycin in the basolateral amygdala (BLA) or dorsal hippocampus (DH) impairs both formation and reconsolidation of memory for inhibitory avoidance (IA) in rats. Male Wistar rats received bilateral infusions of vehicle or rapamycin into the BLA or DH before or after IA training or retrieval. Memory retention was tested at different time points after drug infusion. Rapamycin impaired long-term IA retention when given before or immediately after training or retrieval into the BLA. When infused into the DH, rapamycin produced memory impairment when given before training or immediately after retrieval. The impairing effects of post-retrieval rapamycin required memory retrieval and were not reversed by a reminder shock. The results provide the first evidence that mTOR in the BLA and DH might play a role in IA memory reconsolidation.

Authors+Show Affiliations

Laboratory of Neuropharmacology and Neural Tumor Biology, Department of Pharmacology, Institute for Basic Health Sciences, Federal University of Rio Grande do Sul, 90050-170 Porto Alegre, RS, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22037516

Citation

Jobim, Paulo F C., et al. "Inhibition of mTOR By Rapamycin in the Amygdala or Hippocampus Impairs Formation and Reconsolidation of Inhibitory Avoidance Memory." Neurobiology of Learning and Memory, vol. 97, no. 1, 2012, pp. 105-12.
Jobim PF, Pedroso TR, Christoff RR, et al. Inhibition of mTOR by rapamycin in the amygdala or hippocampus impairs formation and reconsolidation of inhibitory avoidance memory. Neurobiol Learn Mem. 2012;97(1):105-12.
Jobim, P. F., Pedroso, T. R., Christoff, R. R., Werenicz, A., Maurmann, N., Reolon, G. K., & Roesler, R. (2012). Inhibition of mTOR by rapamycin in the amygdala or hippocampus impairs formation and reconsolidation of inhibitory avoidance memory. Neurobiology of Learning and Memory, 97(1), 105-12. https://doi.org/10.1016/j.nlm.2011.10.002
Jobim PF, et al. Inhibition of mTOR By Rapamycin in the Amygdala or Hippocampus Impairs Formation and Reconsolidation of Inhibitory Avoidance Memory. Neurobiol Learn Mem. 2012;97(1):105-12. PubMed PMID: 22037516.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inhibition of mTOR by rapamycin in the amygdala or hippocampus impairs formation and reconsolidation of inhibitory avoidance memory. AU - Jobim,Paulo F C, AU - Pedroso,Thiago R, AU - Christoff,Raissa R, AU - Werenicz,Aline, AU - Maurmann,Natasha, AU - Reolon,Gustavo K, AU - Roesler,Rafael, Y1 - 2011/10/19/ PY - 2011/08/10/received PY - 2011/10/07/revised PY - 2011/10/12/accepted PY - 2011/11/1/entrez PY - 2011/11/1/pubmed PY - 2012/7/12/medline SP - 105 EP - 12 JF - Neurobiology of learning and memory JO - Neurobiol Learn Mem VL - 97 IS - 1 N2 - Mammalian target of rapamycin (mTOR), a central regulator of protein synthesis in neurons, has been implicated in synaptic plasticity and memory. Here we show that mTOR inhibition by rapamycin in the basolateral amygdala (BLA) or dorsal hippocampus (DH) impairs both formation and reconsolidation of memory for inhibitory avoidance (IA) in rats. Male Wistar rats received bilateral infusions of vehicle or rapamycin into the BLA or DH before or after IA training or retrieval. Memory retention was tested at different time points after drug infusion. Rapamycin impaired long-term IA retention when given before or immediately after training or retrieval into the BLA. When infused into the DH, rapamycin produced memory impairment when given before training or immediately after retrieval. The impairing effects of post-retrieval rapamycin required memory retrieval and were not reversed by a reminder shock. The results provide the first evidence that mTOR in the BLA and DH might play a role in IA memory reconsolidation. SN - 1095-9564 UR - https://www.unboundmedicine.com/medline/citation/22037516/Inhibition_of_mTOR_by_rapamycin_in_the_amygdala_or_hippocampus_impairs_formation_and_reconsolidation_of_inhibitory_avoidance_memory_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1074-7427(11)00176-6 DB - PRIME DP - Unbound Medicine ER -