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Folate intake and breast cancer mortality in a cohort of Swedish women.
Breast Cancer Res Treat 2012; 132(1):243-50BC

Abstract

Folate may influence breast cancer development and progression through its role in one-carbon metabolism. However, epidemiologic data on the relation between folate and breast cancer survival are limited. We investigated whether dietary folate intake was associated with survival in 3,116 women diagnosed with breast cancer in the population-based Swedish Mammography Cohort. Participants completed a 67-item food frequency questionnaire in 1987. Cox proportional hazard models were used to calculate hazard ratios (HRs) and 95% confidence intervals (95% CIs) for death from breast cancer and death from any cause. During 25,716 person-years of follow-up from 1987 to 2008, there were 852 deaths with 381 breast cancer deaths. Dietary folate intake was inversely associated with breast cancer and overall mortality. Women in the highest quartile of folate intake had a multivariable HR (95% CI) of death from breast cancer of 0.78 (0.58-1.03) compared to those in the lowest quartile (P (trend) = 0.03). The corresponding HR (95% CI) for death from any cause was 0.79 (0.66-0.96; P (trend) = 0.004). The protective association between dietary folate intake and breast cancer death was strongest among those with ER-negative tumors (HR = 0.42; 95% = CI 0.22-0.79; P (trend) = 0.01) comparing the highest to lowest quartile. Our findings suggest that folate intake before breast cancer diagnosis may improve breast cancer and overall survival. While these findings need to be confirmed in future studies, they do offer assurance that dietary folate intake at the levels observed in our population does not unfavorably affect survival after breast cancer.

Authors+Show Affiliations

Division of Nutritional Epidemiology, The National Institute for Environmental Medicine, Karolinska Institutet, PO Box 210, SE 171 77 Stockholm, Sweden. holly.harris@ki.seNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22037788

Citation

Harris, Holly R., et al. "Folate Intake and Breast Cancer Mortality in a Cohort of Swedish Women." Breast Cancer Research and Treatment, vol. 132, no. 1, 2012, pp. 243-50.
Harris HR, Bergkvist L, Wolk A. Folate intake and breast cancer mortality in a cohort of Swedish women. Breast Cancer Res Treat. 2012;132(1):243-50.
Harris, H. R., Bergkvist, L., & Wolk, A. (2012). Folate intake and breast cancer mortality in a cohort of Swedish women. Breast Cancer Research and Treatment, 132(1), pp. 243-50. doi:10.1007/s10549-011-1838-y.
Harris HR, Bergkvist L, Wolk A. Folate Intake and Breast Cancer Mortality in a Cohort of Swedish Women. Breast Cancer Res Treat. 2012;132(1):243-50. PubMed PMID: 22037788.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Folate intake and breast cancer mortality in a cohort of Swedish women. AU - Harris,Holly R, AU - Bergkvist,Leif, AU - Wolk,Alicja, Y1 - 2011/10/26/ PY - 2011/08/18/received PY - 2011/10/12/accepted PY - 2011/11/1/entrez PY - 2011/11/1/pubmed PY - 2012/5/23/medline SP - 243 EP - 50 JF - Breast cancer research and treatment JO - Breast Cancer Res. Treat. VL - 132 IS - 1 N2 - Folate may influence breast cancer development and progression through its role in one-carbon metabolism. However, epidemiologic data on the relation between folate and breast cancer survival are limited. We investigated whether dietary folate intake was associated with survival in 3,116 women diagnosed with breast cancer in the population-based Swedish Mammography Cohort. Participants completed a 67-item food frequency questionnaire in 1987. Cox proportional hazard models were used to calculate hazard ratios (HRs) and 95% confidence intervals (95% CIs) for death from breast cancer and death from any cause. During 25,716 person-years of follow-up from 1987 to 2008, there were 852 deaths with 381 breast cancer deaths. Dietary folate intake was inversely associated with breast cancer and overall mortality. Women in the highest quartile of folate intake had a multivariable HR (95% CI) of death from breast cancer of 0.78 (0.58-1.03) compared to those in the lowest quartile (P (trend) = 0.03). The corresponding HR (95% CI) for death from any cause was 0.79 (0.66-0.96; P (trend) = 0.004). The protective association between dietary folate intake and breast cancer death was strongest among those with ER-negative tumors (HR = 0.42; 95% = CI 0.22-0.79; P (trend) = 0.01) comparing the highest to lowest quartile. Our findings suggest that folate intake before breast cancer diagnosis may improve breast cancer and overall survival. While these findings need to be confirmed in future studies, they do offer assurance that dietary folate intake at the levels observed in our population does not unfavorably affect survival after breast cancer. SN - 1573-7217 UR - https://www.unboundmedicine.com/medline/citation/22037788/Folate_intake_and_breast_cancer_mortality_in_a_cohort_of_Swedish_women_ L2 - https://doi.org/10.1007/s10549-011-1838-y DB - PRIME DP - Unbound Medicine ER -