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Effect of tart cherry juice (Prunus cerasus) on melatonin levels and enhanced sleep quality.

Abstract

BACKGROUND

Tart Montmorency cherries have been reported to contain high levels of phytochemicals including melatonin, a molecule critical in regulating the sleep-wake cycle in humans.

PURPOSE

The aim of our investigation was to ascertain whether ingestion of a tart cherry juice concentrate would increase the urinary melatonin levels in healthy adults and improve sleep quality.

METHODS

In a randomised, double-blind, placebo-controlled, crossover design, 20 volunteers consumed either a placebo or tart cherry juice concentrate for 7 days. Measures of sleep quality recorded by actigraphy and subjective sleep questionnaires were completed. Sequential urine samples over 48 h were collected and urinary 6-sulfatoxymelatonin (major metabolite of melatonin) determined; cosinor analysis was used to determine melatonin circadian rhythm (mesor, acrophase and amplitude). In addition, total urinary melatonin content was determined over the sampled period. Trial differences were determined using a repeated measures ANOVA.

RESULTS

Total melatonin content was significantly elevated (P < 0.05) in the cherry juice group, whilst no differences were shown between baseline and placebo trials. There were significant increases in time in bed, total sleep time and sleep efficiency total (P < 0.05) with cherry juice supplementation. Although there was no difference in timing of the melatonin circardian rhythm, there was a trend to a higher mesor and amplitude.

CONCLUSIONS

These data suggest that consumption of a tart cherry juice concentrate provides an increase in exogenous melatonin that is beneficial in improving sleep duration and quality in healthy men and women and might be of benefit in managing disturbed sleep.

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  • Authors+Show Affiliations

    ,

    School of Life Sciences, Northumbria University, Northumberland Building, Newcastle upon Tyne, NE1 8ST, UK. glyn.howatson@northumbria.ac.uk

    , , , ,

    Source

    European journal of nutrition 51:8 2012 Dec pg 909-16

    MeSH

    Actigraphy
    Adolescent
    Adult
    Beverages
    Cross-Over Studies
    Dietary Supplements
    Double-Blind Method
    Female
    Fruit
    Humans
    Male
    Melatonin
    Prunus
    Sleep
    Sleep Wake Disorders
    Surveys and Questionnaires
    Young Adult

    Pub Type(s)

    Journal Article
    Randomized Controlled Trial

    Language

    eng

    PubMed ID

    22038497

    Citation

    Howatson, Glyn, et al. "Effect of Tart Cherry Juice (Prunus Cerasus) On Melatonin Levels and Enhanced Sleep Quality." European Journal of Nutrition, vol. 51, no. 8, 2012, pp. 909-16.
    Howatson G, Bell PG, Tallent J, et al. Effect of tart cherry juice (Prunus cerasus) on melatonin levels and enhanced sleep quality. Eur J Nutr. 2012;51(8):909-16.
    Howatson, G., Bell, P. G., Tallent, J., Middleton, B., McHugh, M. P., & Ellis, J. (2012). Effect of tart cherry juice (Prunus cerasus) on melatonin levels and enhanced sleep quality. European Journal of Nutrition, 51(8), pp. 909-16. doi:10.1007/s00394-011-0263-7.
    Howatson G, et al. Effect of Tart Cherry Juice (Prunus Cerasus) On Melatonin Levels and Enhanced Sleep Quality. Eur J Nutr. 2012;51(8):909-16. PubMed PMID: 22038497.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Effect of tart cherry juice (Prunus cerasus) on melatonin levels and enhanced sleep quality. AU - Howatson,Glyn, AU - Bell,Phillip G, AU - Tallent,Jamie, AU - Middleton,Benita, AU - McHugh,Malachy P, AU - Ellis,Jason, Y1 - 2011/10/30/ PY - 2011/07/07/received PY - 2011/10/10/accepted PY - 2011/11/1/entrez PY - 2011/11/1/pubmed PY - 2013/4/20/medline SP - 909 EP - 16 JF - European journal of nutrition JO - Eur J Nutr VL - 51 IS - 8 N2 - BACKGROUND: Tart Montmorency cherries have been reported to contain high levels of phytochemicals including melatonin, a molecule critical in regulating the sleep-wake cycle in humans. PURPOSE: The aim of our investigation was to ascertain whether ingestion of a tart cherry juice concentrate would increase the urinary melatonin levels in healthy adults and improve sleep quality. METHODS: In a randomised, double-blind, placebo-controlled, crossover design, 20 volunteers consumed either a placebo or tart cherry juice concentrate for 7 days. Measures of sleep quality recorded by actigraphy and subjective sleep questionnaires were completed. Sequential urine samples over 48 h were collected and urinary 6-sulfatoxymelatonin (major metabolite of melatonin) determined; cosinor analysis was used to determine melatonin circadian rhythm (mesor, acrophase and amplitude). In addition, total urinary melatonin content was determined over the sampled period. Trial differences were determined using a repeated measures ANOVA. RESULTS: Total melatonin content was significantly elevated (P < 0.05) in the cherry juice group, whilst no differences were shown between baseline and placebo trials. There were significant increases in time in bed, total sleep time and sleep efficiency total (P < 0.05) with cherry juice supplementation. Although there was no difference in timing of the melatonin circardian rhythm, there was a trend to a higher mesor and amplitude. CONCLUSIONS: These data suggest that consumption of a tart cherry juice concentrate provides an increase in exogenous melatonin that is beneficial in improving sleep duration and quality in healthy men and women and might be of benefit in managing disturbed sleep. SN - 1436-6215 UR - https://www.unboundmedicine.com/medline/citation/22038497/abstract/Effect_of_tart_cherry_juice__Prunus_cerasus__on_melatonin_levels_and_enhanced_sleep_quality_ L2 - https://dx.doi.org/10.1007/s00394-011-0263-7 DB - PRIME DP - Unbound Medicine ER -