Tags

Type your tag names separated by a space and hit enter

Tamsulosin reduces nighttime urine production in benign prostatic hyperplasia patients with nocturnal polyuria: a prospective open-label long-term study using frequency-volume chart.
Neurourol Urodyn. 2012 Jan; 31(1):80-5.NU

Abstract

AIMS

The effects of tamsulosin treatment on changes in frequency-volume chart (FVC) data, especially nighttime urine production, over time were assessed, and the mechanisms underlying the improvement of nocturia in benign prostatic hyperplasia (BPH) patients with nocturnal polyuria (NP) are discussed.

METHODS

A total of 104 patients with lower urinary tract symptoms secondary to BPH were enrolled. After enrollment in the study, the patients were treated with tamsulosin (0.2 mg) once daily. Visits were scheduled every 4 weeks until week 12 (month 3) after study entry, and then every 12 weeks subsequently. All patients completed the International Prostate Symptom Score (IPSS), quality of life (QOL) index, and 3-day FVC, and underwent uroflowmetry at enrollment and on each visit.

RESULTS

Eighty-two patients (mean age: 70.9 ± 7.1 years) were analyzed for 24 months after treatment. Patients were divided into two groups, NP and nonNP, based on FVC outcome. The IPSS, QOL index, and maximum flow rate improved during the 24-month period after treatment in both groups. Mean daytime urine volume significantly increased in the NP group, but no changes were detected in the nonNP group. Mean nighttime urine frequency significantly decreased in the NP group over a 24-month period, and was associated with a significant decrease in nighttime urine volume that was not found in the nonNP group. Maximum voided volume increased most months after treatment in both groups.

CONCLUSIONS

The present long-term prospective study using FVC demonstrated that tamsulosin reduced nighttime urine production in BPH patients with NP.

Authors+Show Affiliations

Department of Nephro-Urology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan. ykojima@med.nagoya-cu.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22038792

Citation

Kojima, Yoshiyuki, et al. "Tamsulosin Reduces Nighttime Urine Production in Benign Prostatic Hyperplasia Patients With Nocturnal Polyuria: a Prospective Open-label Long-term Study Using Frequency-volume Chart." Neurourology and Urodynamics, vol. 31, no. 1, 2012, pp. 80-5.
Kojima Y, Sasaki S, Imura M, et al. Tamsulosin reduces nighttime urine production in benign prostatic hyperplasia patients with nocturnal polyuria: a prospective open-label long-term study using frequency-volume chart. Neurourol Urodyn. 2012;31(1):80-5.
Kojima, Y., Sasaki, S., Imura, M., Kubota, Y., Hayashi, Y., & Kohri, K. (2012). Tamsulosin reduces nighttime urine production in benign prostatic hyperplasia patients with nocturnal polyuria: a prospective open-label long-term study using frequency-volume chart. Neurourology and Urodynamics, 31(1), 80-5. https://doi.org/10.1002/nau.21224
Kojima Y, et al. Tamsulosin Reduces Nighttime Urine Production in Benign Prostatic Hyperplasia Patients With Nocturnal Polyuria: a Prospective Open-label Long-term Study Using Frequency-volume Chart. Neurourol Urodyn. 2012;31(1):80-5. PubMed PMID: 22038792.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Tamsulosin reduces nighttime urine production in benign prostatic hyperplasia patients with nocturnal polyuria: a prospective open-label long-term study using frequency-volume chart. AU - Kojima,Yoshiyuki, AU - Sasaki,Shoichi, AU - Imura,Makoto, AU - Kubota,Yasue, AU - Hayashi,Yutaro, AU - Kohri,Kenjiro, Y1 - 2011/10/28/ PY - 2011/06/27/received PY - 2011/09/05/accepted PY - 2011/11/1/entrez PY - 2011/11/1/pubmed PY - 2012/7/3/medline SP - 80 EP - 5 JF - Neurourology and urodynamics JO - Neurourol. Urodyn. VL - 31 IS - 1 N2 - AIMS: The effects of tamsulosin treatment on changes in frequency-volume chart (FVC) data, especially nighttime urine production, over time were assessed, and the mechanisms underlying the improvement of nocturia in benign prostatic hyperplasia (BPH) patients with nocturnal polyuria (NP) are discussed. METHODS: A total of 104 patients with lower urinary tract symptoms secondary to BPH were enrolled. After enrollment in the study, the patients were treated with tamsulosin (0.2 mg) once daily. Visits were scheduled every 4 weeks until week 12 (month 3) after study entry, and then every 12 weeks subsequently. All patients completed the International Prostate Symptom Score (IPSS), quality of life (QOL) index, and 3-day FVC, and underwent uroflowmetry at enrollment and on each visit. RESULTS: Eighty-two patients (mean age: 70.9 ± 7.1 years) were analyzed for 24 months after treatment. Patients were divided into two groups, NP and nonNP, based on FVC outcome. The IPSS, QOL index, and maximum flow rate improved during the 24-month period after treatment in both groups. Mean daytime urine volume significantly increased in the NP group, but no changes were detected in the nonNP group. Mean nighttime urine frequency significantly decreased in the NP group over a 24-month period, and was associated with a significant decrease in nighttime urine volume that was not found in the nonNP group. Maximum voided volume increased most months after treatment in both groups. CONCLUSIONS: The present long-term prospective study using FVC demonstrated that tamsulosin reduced nighttime urine production in BPH patients with NP. SN - 1520-6777 UR - https://www.unboundmedicine.com/medline/citation/22038792/Tamsulosin_reduces_nighttime_urine_production_in_benign_prostatic_hyperplasia_patients_with_nocturnal_polyuria:_a_prospective_open_label_long_term_study_using_frequency_volume_chart_ L2 - https://doi.org/10.1002/nau.21224 DB - PRIME DP - Unbound Medicine ER -