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Food-frequency questionnaire-based estimates of total antioxidant capacity and risk of non-Hodgkin lymphoma.
Int J Cancer 2012; 131(5):1158-68IJ

Abstract

Antioxidants, primarily from fruits and vegetables, have been hypothesized to protect against non-Hodgkin lymphoma (NHL). The oxygen radical absorbance capacity (ORAC) assay, which measures total antioxidant capacity of individual foods and accounts for synergism, can be estimated using a food-frequency questionnaire (FFQ). We tested the hypothesis that higher intake of antioxidant nutrients from foods, supplements and FFQ-based ORAC values are associated with a lower risk of NHL in a clinic-based study of 603 incident cases and 1,007 frequency-matched controls. Diet was assessed with a 128-item FFQ. Logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals adjusted for age, sex, residence and total energy. Dietary intake of α-tocopherol (OR=0.50; p-trend=0.0002), β-carotene (OR=0.58; p-trend=0.0005), lutein/zeaxanthin (OR=0.62; p-trend=0.005), zinc (OR=0.54; p-trend=0.003) and chromium (OR=0.68; p-trend=0.032) was inversely associated with NHL risk. Inclusion of supplement use had little impact on these associations. Total vegetables (OR=0.52; p-trend<0.0001), particularly green leafy (OR=0.52; p-trend<0.0001) and cruciferous (OR=0.68; p-trend=0.045) vegetables, were inversely associated with NHL risk. NHL risk was inversely associated with both hydrophilic ORAC (OR=0.61, p-trend=0.003) and lipophilic ORAC (OR=0.48, p-trend=0.0002), although after simultaneous adjustment for other antioxidants or total vegetables, only the association for lipophilic ORAC remained significant. There was no striking heterogeneity in results across the common NHL subtypes. Higher antioxidant intake as estimated by the FFQ-ORAC, particularly the lipophilic component, was associated with a lower NHL risk after accounting for other antioxidant nutrients and vegetable intake, supporting this as potentially useful summary measure of total antioxidant intake.

Authors+Show Affiliations

Division of Hematology, Department of Medicine, Mayo Clinic College of Medicine, Rochester, MN 55905, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

22038870

Citation

Holtan, Shernan G., et al. "Food-frequency Questionnaire-based Estimates of Total Antioxidant Capacity and Risk of non-Hodgkin Lymphoma." International Journal of Cancer, vol. 131, no. 5, 2012, pp. 1158-68.
Holtan SG, O'Connor HM, Fredericksen ZS, et al. Food-frequency questionnaire-based estimates of total antioxidant capacity and risk of non-Hodgkin lymphoma. Int J Cancer. 2012;131(5):1158-68.
Holtan, S. G., O'Connor, H. M., Fredericksen, Z. S., Liebow, M., Thompson, C. A., Macon, W. R., ... Cerhan, J. R. (2012). Food-frequency questionnaire-based estimates of total antioxidant capacity and risk of non-Hodgkin lymphoma. International Journal of Cancer, 131(5), pp. 1158-68. doi:10.1002/ijc.26491.
Holtan SG, et al. Food-frequency Questionnaire-based Estimates of Total Antioxidant Capacity and Risk of non-Hodgkin Lymphoma. Int J Cancer. 2012 Sep 1;131(5):1158-68. PubMed PMID: 22038870.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Food-frequency questionnaire-based estimates of total antioxidant capacity and risk of non-Hodgkin lymphoma. AU - Holtan,Shernan G, AU - O'Connor,Helen M, AU - Fredericksen,Zachary S, AU - Liebow,Mark, AU - Thompson,Carrie A, AU - Macon,William R, AU - Micallef,Ivana N, AU - Wang,Alice H, AU - Slager,Susan L, AU - Habermann,Thomas M, AU - Call,Timothy G, AU - Cerhan,James R, Y1 - 2011/11/30/ PY - 2011/04/17/received PY - 2011/09/12/accepted PY - 2011/11/1/entrez PY - 2011/11/1/pubmed PY - 2012/9/21/medline SP - 1158 EP - 68 JF - International journal of cancer JO - Int. J. Cancer VL - 131 IS - 5 N2 - Antioxidants, primarily from fruits and vegetables, have been hypothesized to protect against non-Hodgkin lymphoma (NHL). The oxygen radical absorbance capacity (ORAC) assay, which measures total antioxidant capacity of individual foods and accounts for synergism, can be estimated using a food-frequency questionnaire (FFQ). We tested the hypothesis that higher intake of antioxidant nutrients from foods, supplements and FFQ-based ORAC values are associated with a lower risk of NHL in a clinic-based study of 603 incident cases and 1,007 frequency-matched controls. Diet was assessed with a 128-item FFQ. Logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals adjusted for age, sex, residence and total energy. Dietary intake of α-tocopherol (OR=0.50; p-trend=0.0002), β-carotene (OR=0.58; p-trend=0.0005), lutein/zeaxanthin (OR=0.62; p-trend=0.005), zinc (OR=0.54; p-trend=0.003) and chromium (OR=0.68; p-trend=0.032) was inversely associated with NHL risk. Inclusion of supplement use had little impact on these associations. Total vegetables (OR=0.52; p-trend<0.0001), particularly green leafy (OR=0.52; p-trend<0.0001) and cruciferous (OR=0.68; p-trend=0.045) vegetables, were inversely associated with NHL risk. NHL risk was inversely associated with both hydrophilic ORAC (OR=0.61, p-trend=0.003) and lipophilic ORAC (OR=0.48, p-trend=0.0002), although after simultaneous adjustment for other antioxidants or total vegetables, only the association for lipophilic ORAC remained significant. There was no striking heterogeneity in results across the common NHL subtypes. Higher antioxidant intake as estimated by the FFQ-ORAC, particularly the lipophilic component, was associated with a lower NHL risk after accounting for other antioxidant nutrients and vegetable intake, supporting this as potentially useful summary measure of total antioxidant intake. SN - 1097-0215 UR - https://www.unboundmedicine.com/medline/citation/22038870/Food_frequency_questionnaire_based_estimates_of_total_antioxidant_capacity_and_risk_of_non_Hodgkin_lymphoma_ L2 - https://doi.org/10.1002/ijc.26491 DB - PRIME DP - Unbound Medicine ER -