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Alcohol drinking and bladder cancer risk: a meta-analysis.
Ann Oncol 2012; 23(6):1586-93AO

Abstract

BACKGROUND

We aimed at investigating the risk of bladder cancer at different levels of alcohol consumption by conducting a meta-analysis of epidemiological studies.

PATIENTS AND METHODS

In October 2010, we carried out a systematic literature search in the Medline database, using PubMed. We identified 16 case-control and 3 cohort studies, including a total of 11 219 cases of bladder cancer, satisfying the inclusion criteria for this meta-analysis. Moderate alcohol intake was defined as <3 drinks per day (i.e. <37.5 g of ethanol per day) and heavy intake as ≥3 drinks/day. Pooled estimates of the relative risks (RR) and the corresponding 95% confidence intervals (CI) were calculated using random effects models.

RESULTS

Compared with non-drinkers, the pooled RRs of bladder cancer were 1.00 (95% CI 0.92-1.09) for moderate and 1.02 (95% CI 0.78-1.33) for heavy alcohol drinkers. When we excluded four studies that did not adjust for tobacco smoking, the corresponding estimates were 0.98 (95% CI 0.89-1.07) and 0.97 (95% CI 0.72-1.31).

CONCLUSIONS

This meta-analysis of epidemiological studies provides definite evidence on the absence of any material association between alcohol drinking and bladder cancer risk, even at high levels of consumption.

Authors+Show Affiliations

Department of Epidemiology, Mario Negri Institute for Pharmacological Research, Milan, Italy. claudio.pelucchi@marionegri.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22039083

Citation

Pelucchi, C, et al. "Alcohol Drinking and Bladder Cancer Risk: a Meta-analysis." Annals of Oncology : Official Journal of the European Society for Medical Oncology, vol. 23, no. 6, 2012, pp. 1586-93.
Pelucchi C, Galeone C, Tramacere I, et al. Alcohol drinking and bladder cancer risk: a meta-analysis. Ann Oncol. 2012;23(6):1586-93.
Pelucchi, C., Galeone, C., Tramacere, I., Bagnardi, V., Negri, E., Islami, F., ... La Vecchia, C. (2012). Alcohol drinking and bladder cancer risk: a meta-analysis. Annals of Oncology : Official Journal of the European Society for Medical Oncology, 23(6), pp. 1586-93. doi:10.1093/annonc/mdr460.
Pelucchi C, et al. Alcohol Drinking and Bladder Cancer Risk: a Meta-analysis. Ann Oncol. 2012;23(6):1586-93. PubMed PMID: 22039083.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alcohol drinking and bladder cancer risk: a meta-analysis. AU - Pelucchi,C, AU - Galeone,C, AU - Tramacere,I, AU - Bagnardi,V, AU - Negri,E, AU - Islami,F, AU - Scotti,L, AU - Bellocco,R, AU - Corrao,G, AU - Boffetta,P, AU - La Vecchia,C, Y1 - 2011/10/29/ PY - 2011/11/1/entrez PY - 2011/11/1/pubmed PY - 2012/9/21/medline SP - 1586 EP - 93 JF - Annals of oncology : official journal of the European Society for Medical Oncology JO - Ann. Oncol. VL - 23 IS - 6 N2 - BACKGROUND: We aimed at investigating the risk of bladder cancer at different levels of alcohol consumption by conducting a meta-analysis of epidemiological studies. PATIENTS AND METHODS: In October 2010, we carried out a systematic literature search in the Medline database, using PubMed. We identified 16 case-control and 3 cohort studies, including a total of 11 219 cases of bladder cancer, satisfying the inclusion criteria for this meta-analysis. Moderate alcohol intake was defined as <3 drinks per day (i.e. <37.5 g of ethanol per day) and heavy intake as ≥3 drinks/day. Pooled estimates of the relative risks (RR) and the corresponding 95% confidence intervals (CI) were calculated using random effects models. RESULTS: Compared with non-drinkers, the pooled RRs of bladder cancer were 1.00 (95% CI 0.92-1.09) for moderate and 1.02 (95% CI 0.78-1.33) for heavy alcohol drinkers. When we excluded four studies that did not adjust for tobacco smoking, the corresponding estimates were 0.98 (95% CI 0.89-1.07) and 0.97 (95% CI 0.72-1.31). CONCLUSIONS: This meta-analysis of epidemiological studies provides definite evidence on the absence of any material association between alcohol drinking and bladder cancer risk, even at high levels of consumption. SN - 1569-8041 UR - https://www.unboundmedicine.com/medline/citation/22039083/Alcohol_drinking_and_bladder_cancer_risk:_a_meta_analysis_ L2 - https://academic.oup.com/annonc/article-lookup/doi/10.1093/annonc/mdr460 DB - PRIME DP - Unbound Medicine ER -