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Evaluation of antihyperglycemic activity of Cocos nucifera Linn. on streptozotocin induced type 2 diabetic rats.
J Ethnopharmacol. 2011 Dec 08; 138(3):769-73.JE

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE

The plant Cocos nucifera Linn. (Arecaceae) is commonly known as coconut. Traditionally the juice of the young spadix when fresh is used in diarrhea and diabetes. The objective of the present study was to investigate the effect of antidiabetic activity and effect on lipid profile as well as cardioprotective effect of hydro-methanol extract of Cocos nucifera (HECN) on streptozotocin (STZ)-induced diabetic rats.

MATERIALS AND METHODS

After 72 h of STZ (50 mg/kg, b.w. i.p.) administration, animals showing plasma sugar level more than 250 mg/dl were considered as diabetic rat. Fasting blood glucose (FBG) levels were measured on 0th (after 72 h of STZ), 5th, 10th, and 15th day. On the 15th day all the animals were sacrificed and the serum biochemical parameters and antioxidant enzyme status were measured.

RESULTS

HECN treated animals showed a significant reduction in FBG level as compared with diabetic control group. Serum enzyme level (SGOT, SGPT, SALP), lipid peroxidation and antioxidant enzyme level such as CAT, GSH, SOD and cholesterol and triglycerides in the HECN treated groups were restored towards normal level as compared to diabetic control groups and the values were comparable with the standard groups (glibenclamide).

CONCLUSION

Improvement in the FBG and the restoration of all other biomarker as well as enzymes indicates that HECN has very good antidiabetic activity with very low side effects and provides a scientific rationale for the use as an antidiabetic agent.

Authors+Show Affiliations

Department of Pharmaceutical Technology, Jadavpur University, Kolkata, India. sagar_n2007@yahoo.co.inNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22041106

Citation

Naskar, Sagar, et al. "Evaluation of Antihyperglycemic Activity of Cocos Nucifera Linn. On Streptozotocin Induced Type 2 Diabetic Rats." Journal of Ethnopharmacology, vol. 138, no. 3, 2011, pp. 769-73.
Naskar S, Mazumder UK, Pramanik G, et al. Evaluation of antihyperglycemic activity of Cocos nucifera Linn. on streptozotocin induced type 2 diabetic rats. J Ethnopharmacol. 2011;138(3):769-73.
Naskar, S., Mazumder, U. K., Pramanik, G., Gupta, M., Kumar, R. B., Bala, A., & Islam, A. (2011). Evaluation of antihyperglycemic activity of Cocos nucifera Linn. on streptozotocin induced type 2 diabetic rats. Journal of Ethnopharmacology, 138(3), 769-73. https://doi.org/10.1016/j.jep.2011.10.021
Naskar S, et al. Evaluation of Antihyperglycemic Activity of Cocos Nucifera Linn. On Streptozotocin Induced Type 2 Diabetic Rats. J Ethnopharmacol. 2011 Dec 8;138(3):769-73. PubMed PMID: 22041106.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of antihyperglycemic activity of Cocos nucifera Linn. on streptozotocin induced type 2 diabetic rats. AU - Naskar,Sagar, AU - Mazumder,Upal K, AU - Pramanik,Goutam, AU - Gupta,Malaya, AU - Kumar,R B Suresh, AU - Bala,Asis, AU - Islam,Aminul, Y1 - 2011/10/20/ PY - 2011/04/09/received PY - 2011/09/24/revised PY - 2011/10/15/accepted PY - 2011/11/2/entrez PY - 2011/11/2/pubmed PY - 2012/4/13/medline SP - 769 EP - 73 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 138 IS - 3 N2 - ETHNOPHARMACOLOGICAL RELEVANCE: The plant Cocos nucifera Linn. (Arecaceae) is commonly known as coconut. Traditionally the juice of the young spadix when fresh is used in diarrhea and diabetes. The objective of the present study was to investigate the effect of antidiabetic activity and effect on lipid profile as well as cardioprotective effect of hydro-methanol extract of Cocos nucifera (HECN) on streptozotocin (STZ)-induced diabetic rats. MATERIALS AND METHODS: After 72 h of STZ (50 mg/kg, b.w. i.p.) administration, animals showing plasma sugar level more than 250 mg/dl were considered as diabetic rat. Fasting blood glucose (FBG) levels were measured on 0th (after 72 h of STZ), 5th, 10th, and 15th day. On the 15th day all the animals were sacrificed and the serum biochemical parameters and antioxidant enzyme status were measured. RESULTS: HECN treated animals showed a significant reduction in FBG level as compared with diabetic control group. Serum enzyme level (SGOT, SGPT, SALP), lipid peroxidation and antioxidant enzyme level such as CAT, GSH, SOD and cholesterol and triglycerides in the HECN treated groups were restored towards normal level as compared to diabetic control groups and the values were comparable with the standard groups (glibenclamide). CONCLUSION: Improvement in the FBG and the restoration of all other biomarker as well as enzymes indicates that HECN has very good antidiabetic activity with very low side effects and provides a scientific rationale for the use as an antidiabetic agent. SN - 1872-7573 UR - https://www.unboundmedicine.com/medline/citation/22041106/Evaluation_of_antihyperglycemic_activity_of_Cocos_nucifera_Linn__on_streptozotocin_induced_type_2_diabetic_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(11)00759-8 DB - PRIME DP - Unbound Medicine ER -