Tags

Type your tag names separated by a space and hit enter

Cigarette smoking and its association with overlapping gastroesophageal reflux disease, functional dyspepsia, or irritable bowel syndrome.
Intern Med. 2011; 50(21):2443-7.IM

Abstract

BACKGROUND

Gastroesophageal reflux disease (GERD), functional dyspepsia (FD), and irritable bowel syndrome (IBS) are common gastrointestinal diseases. Several studies have shown a significant occurrence of overlap among these 3 diseases. The purpose of this study was to examine the factors associated with such disease overlap in Japanese adults.

METHODS

We performed a cross-sectional study on Japanese workers who visited a clinic for a routine health check-up and asked them to fill out a self-report questionnaire. GERD was defined as episodes of heartburn and/or acid regurgitation at least once a week, and the diagnosis of FD and IBS was based on Rome III criteria. A logistic regression model was used to identify risk factors, and odds ratio (OR) was calculated with 95% confidence intervals (CIs).

RESULTS

Disease overlaps were found in 160 (6.0%) of the 2680 eligible subjects. Female gender was associated with GERD + IBS (OR=1.99; 95% CI, 1.06-3.75), and FD + IBS (OR=1.72; 95% CI, 1.03-2.85), and lower body mass index was negatively associated with FD + IBS (OR=0.54; 96% CI, 0.34-0.87). Cigarette smoking was a common factor associated with the overlaps: GERD + FD (OR=2.14; 95% CI, 1.22-3.76), GERD + IBS (OR=3.16; 95% CI, 1.75-3.71), FD + IBS (OR=2.26; 95% CI, 1.40-3.66), and GERD + FD + IBS (OR=4.08; 95% CI, 1.66-10.07). The associations between smoking habits and overlaps were stronger in smokers who smoked ≥1 pack per day as compared to those who smoked <1 pack per day.

CONCLUSION

Cigarette smoking was significantly associated with overlaps among GERD, FD, and IBS in Japanese adults.

Authors+Show Affiliations

Department of Gastroenterology, Osaka City University Graduate School of Medicine, Japan. yasu@med.osaka-cu.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22041340

Citation

Fujiwara, Yasuhiro, et al. "Cigarette Smoking and Its Association With Overlapping Gastroesophageal Reflux Disease, Functional Dyspepsia, or Irritable Bowel Syndrome." Internal Medicine (Tokyo, Japan), vol. 50, no. 21, 2011, pp. 2443-7.
Fujiwara Y, Kubo M, Kohata Y, et al. Cigarette smoking and its association with overlapping gastroesophageal reflux disease, functional dyspepsia, or irritable bowel syndrome. Intern Med. 2011;50(21):2443-7.
Fujiwara, Y., Kubo, M., Kohata, Y., Machida, H., Okazaki, H., Yamagami, H., Tanigawa, T., Watanabe, K., Watanabe, T., Tominaga, K., & Arakawa, T. (2011). Cigarette smoking and its association with overlapping gastroesophageal reflux disease, functional dyspepsia, or irritable bowel syndrome. Internal Medicine (Tokyo, Japan), 50(21), 2443-7.
Fujiwara Y, et al. Cigarette Smoking and Its Association With Overlapping Gastroesophageal Reflux Disease, Functional Dyspepsia, or Irritable Bowel Syndrome. Intern Med. 2011;50(21):2443-7. PubMed PMID: 22041340.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cigarette smoking and its association with overlapping gastroesophageal reflux disease, functional dyspepsia, or irritable bowel syndrome. AU - Fujiwara,Yasuhiro, AU - Kubo,Makiko, AU - Kohata,Yukie, AU - Machida,Hirohisa, AU - Okazaki,Hirotoshi, AU - Yamagami,Hirokazu, AU - Tanigawa,Tetsuya, AU - Watanabe,Kenji, AU - Watanabe,Toshio, AU - Tominaga,Kazunari, AU - Arakawa,Tetsuo, Y1 - 2011/11/01/ PY - 2011/11/2/entrez PY - 2011/11/2/pubmed PY - 2012/8/14/medline SP - 2443 EP - 7 JF - Internal medicine (Tokyo, Japan) JO - Intern. Med. VL - 50 IS - 21 N2 - BACKGROUND: Gastroesophageal reflux disease (GERD), functional dyspepsia (FD), and irritable bowel syndrome (IBS) are common gastrointestinal diseases. Several studies have shown a significant occurrence of overlap among these 3 diseases. The purpose of this study was to examine the factors associated with such disease overlap in Japanese adults. METHODS: We performed a cross-sectional study on Japanese workers who visited a clinic for a routine health check-up and asked them to fill out a self-report questionnaire. GERD was defined as episodes of heartburn and/or acid regurgitation at least once a week, and the diagnosis of FD and IBS was based on Rome III criteria. A logistic regression model was used to identify risk factors, and odds ratio (OR) was calculated with 95% confidence intervals (CIs). RESULTS: Disease overlaps were found in 160 (6.0%) of the 2680 eligible subjects. Female gender was associated with GERD + IBS (OR=1.99; 95% CI, 1.06-3.75), and FD + IBS (OR=1.72; 95% CI, 1.03-2.85), and lower body mass index was negatively associated with FD + IBS (OR=0.54; 96% CI, 0.34-0.87). Cigarette smoking was a common factor associated with the overlaps: GERD + FD (OR=2.14; 95% CI, 1.22-3.76), GERD + IBS (OR=3.16; 95% CI, 1.75-3.71), FD + IBS (OR=2.26; 95% CI, 1.40-3.66), and GERD + FD + IBS (OR=4.08; 95% CI, 1.66-10.07). The associations between smoking habits and overlaps were stronger in smokers who smoked ≥1 pack per day as compared to those who smoked <1 pack per day. CONCLUSION: Cigarette smoking was significantly associated with overlaps among GERD, FD, and IBS in Japanese adults. SN - 1349-7235 UR - https://www.unboundmedicine.com/medline/citation/22041340/Cigarette_smoking_and_its_association_with_overlapping_gastroesophageal_reflux_disease_functional_dyspepsia_or_irritable_bowel_syndrome_ L2 - https://joi.jlc.jst.go.jp/JST.JSTAGE/internalmedicine/50.6012?from=PubMed DB - PRIME DP - Unbound Medicine ER -