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Nonnecrobiotic necrobiotic xanthogranuloma as an initial manifestation of paraproteinemia and small lymphocytic lymphoma in a patient with Sjögren syndrome.
Am J Dermatopathol 2011; 33(8):855-7AJ

Abstract

We report a unique case of periocular nonnecrobiotic necrobiotic xanthogranuloma in a 52-year-old white woman with Sjögren syndrome who was subsequently found to have an immunoglobulin G paraproteinemia and coexisting small lymphocytic lymphoma. Therapy with fludarabine, cytoxan, and rituximab (FCR) resulted in a dramatic resolution of her sicca symptoms and periocular xanthogranulomas. This case further illustrates the association of hematolymphoid disorders with cutaneous xanthogranulomatous disease and the importance of additional appropriate laboratory and radiologic investigation for the accurate diagnosis of an underlying malignancy.

Authors+Show Affiliations

Department of Hematopathology, H. Lee Moffitt Cancer Center, University of South Florida, USA. mojdeh.naghashpour@moffitt.orgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

22042261

Citation

Naghashpour, Mojdeh, et al. "Nonnecrobiotic Necrobiotic Xanthogranuloma as an Initial Manifestation of Paraproteinemia and Small Lymphocytic Lymphoma in a Patient With Sjögren Syndrome." The American Journal of Dermatopathology, vol. 33, no. 8, 2011, pp. 855-7.
Naghashpour M, Setoodeh R, Moscinski L, et al. Nonnecrobiotic necrobiotic xanthogranuloma as an initial manifestation of paraproteinemia and small lymphocytic lymphoma in a patient with Sjögren syndrome. Am J Dermatopathol. 2011;33(8):855-7.
Naghashpour, M., Setoodeh, R., Moscinski, L., Bergier, G., McCardle, T., Glass, F., & Sokol, L. (2011). Nonnecrobiotic necrobiotic xanthogranuloma as an initial manifestation of paraproteinemia and small lymphocytic lymphoma in a patient with Sjögren syndrome. The American Journal of Dermatopathology, 33(8), pp. 855-7. doi:10.1097/DAD.0b013e3182051fce.
Naghashpour M, et al. Nonnecrobiotic Necrobiotic Xanthogranuloma as an Initial Manifestation of Paraproteinemia and Small Lymphocytic Lymphoma in a Patient With Sjögren Syndrome. Am J Dermatopathol. 2011;33(8):855-7. PubMed PMID: 22042261.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nonnecrobiotic necrobiotic xanthogranuloma as an initial manifestation of paraproteinemia and small lymphocytic lymphoma in a patient with Sjögren syndrome. AU - Naghashpour,Mojdeh, AU - Setoodeh,Reza, AU - Moscinski,Lynn, AU - Bergier,Gregoire, AU - McCardle,Timothy, AU - Glass,Frank, AU - Sokol,Lubomir, PY - 2011/11/2/entrez PY - 2011/11/2/pubmed PY - 2012/4/6/medline SP - 855 EP - 7 JF - The American Journal of dermatopathology JO - Am J Dermatopathol VL - 33 IS - 8 N2 - We report a unique case of periocular nonnecrobiotic necrobiotic xanthogranuloma in a 52-year-old white woman with Sjögren syndrome who was subsequently found to have an immunoglobulin G paraproteinemia and coexisting small lymphocytic lymphoma. Therapy with fludarabine, cytoxan, and rituximab (FCR) resulted in a dramatic resolution of her sicca symptoms and periocular xanthogranulomas. This case further illustrates the association of hematolymphoid disorders with cutaneous xanthogranulomatous disease and the importance of additional appropriate laboratory and radiologic investigation for the accurate diagnosis of an underlying malignancy. SN - 1533-0311 UR - https://www.unboundmedicine.com/medline/citation/22042261/Nonnecrobiotic_necrobiotic_xanthogranuloma_as_an_initial_manifestation_of_paraproteinemia_and_small_lymphocytic_lymphoma_in_a_patient_with_Sjögren_syndrome_ L2 - http://Insights.ovid.com/pubmed?pmid=22042261 DB - PRIME DP - Unbound Medicine ER -