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Clinical and epidemiological characteristics of respiratory syncytial virus and influenza virus associated hospitalization in urban Thai infants.
J Med Assoc Thai. 2011 Aug; 94 Suppl 3:S164-71.JM

Abstract

BACKGROUND

Respiratory syncytial virus (RSV) and influenza infections are among the leading cause of hospitalized lower respiratory tract infections (LRTI) in children especially among those younger than 1 year of age. Few descriptions of these 2 important viruses in Thai children less than 1 year of age have been published.

MATERIAL AND METHOD

The authors conducted a prospective study of children 1-12 months old hospitalized at a pediatric tertiary-care hospital in Bangkok with LRTI during the period December 2007 to August 2009. Respiratory specimens were tested for influenza A/B virus and RSV using a reverse-transcriptase polymerase chain reaction (RT-PCR).

RESULTS

Twenty-six (7.3%) had RT-PCR positive for influenza and 104 (29.4%) for RSV from 354 infants. Clinical diagnoses included pneumonia (73.4%), bronchiolitis (17.55%), croup (6.5%) and bronchitis (2.5%) and were similar among groups except the proportion of croup was significantly lower in RSV (p = .018). The proportion of RSV infection was highest between July and October (42-76%). RSV patients were more likely to present with higher temperature than the negative RT-PCR patients (p = .031). Oseltamivir was prescribed in 7.7% of influenza infections. Intravenous antibiotics were prescribed in 69.2%, 56.7% and 60.7% of the influenza, RSV and negative group respectively (p = .736). Percentages of patients requiring mechanical ventilation were 3.8, 6.7 and 6.3% among the influenza, RSV and negative group respectively (p = .861). Three patients died: 2 from RSV and 1 from the negative group. All three fatality cases had existing co-morbidity.

CONCLUSION

A high proportion of RSV was detected in infants hospitalized with LRTI especially during July to October. High proportion of antibiotic prescription and relatively low rate of oseltamivir treatment were identified. Surveillance data and the availability of a rapid and reliable viral diagnostic test may help guide treatment, thereby improve outcome of this vulnerable population.

Authors+Show Affiliations

Suntarattiwong P
Queen Sirikit National Institute of Child Health, College of Medicine, Rangsit University, Bangkok, Thailand. drjunesunta@yahoo.com
Sojisirikul K
No affiliation info available
Sitaposa P
No affiliation info available
Pornpatanangkoon A
No affiliation info available
Chittaganpitch M
No affiliation info available
Srijuntongsiri S
No affiliation info available
Chotpitayasunondh T
No affiliation info available

MeSH

Antiviral AgentsAsiansFemaleHospitalizationHospitals, TeachingHumansInfantInfluenza, HumanMaleOrthomyxoviridaeProspective StudiesRespiratory Syncytial Virus InfectionsRespiratory Syncytial VirusesReverse Transcriptase Polymerase Chain ReactionThailandTreatment OutcomeUrban Population

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22043771

Citation

Suntarattiwong, Piyarat, et al. "Clinical and Epidemiological Characteristics of Respiratory Syncytial Virus and Influenza Virus Associated Hospitalization in Urban Thai Infants." Journal of the Medical Association of Thailand = Chotmaihet Thangphaet, vol. 94 Suppl 3, 2011, pp. S164-71.
Suntarattiwong P, Sojisirikul K, Sitaposa P, et al. Clinical and epidemiological characteristics of respiratory syncytial virus and influenza virus associated hospitalization in urban Thai infants. J Med Assoc Thai. 2011;94 Suppl 3:S164-71.
Suntarattiwong, P., Sojisirikul, K., Sitaposa, P., Pornpatanangkoon, A., Chittaganpitch, M., Srijuntongsiri, S., & Chotpitayasunondh, T. (2011). Clinical and epidemiological characteristics of respiratory syncytial virus and influenza virus associated hospitalization in urban Thai infants. Journal of the Medical Association of Thailand = Chotmaihet Thangphaet, 94 Suppl 3, S164-71.
Suntarattiwong P, et al. Clinical and Epidemiological Characteristics of Respiratory Syncytial Virus and Influenza Virus Associated Hospitalization in Urban Thai Infants. J Med Assoc Thai. 2011;94 Suppl 3:S164-71. PubMed PMID: 22043771.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical and epidemiological characteristics of respiratory syncytial virus and influenza virus associated hospitalization in urban Thai infants. AU - Suntarattiwong,Piyarat, AU - Sojisirikul,Kanokwan, AU - Sitaposa,Pranee, AU - Pornpatanangkoon,Aruntip, AU - Chittaganpitch,Malinee, AU - Srijuntongsiri,Sarunya, AU - Chotpitayasunondh,Tawee, PY - 2011/11/3/entrez PY - 2011/11/3/pubmed PY - 2012/2/1/medline SP - S164 EP - 71 JF - Journal of the Medical Association of Thailand = Chotmaihet thangphaet JO - J Med Assoc Thai VL - 94 Suppl 3 N2 - BACKGROUND: Respiratory syncytial virus (RSV) and influenza infections are among the leading cause of hospitalized lower respiratory tract infections (LRTI) in children especially among those younger than 1 year of age. Few descriptions of these 2 important viruses in Thai children less than 1 year of age have been published. MATERIAL AND METHOD: The authors conducted a prospective study of children 1-12 months old hospitalized at a pediatric tertiary-care hospital in Bangkok with LRTI during the period December 2007 to August 2009. Respiratory specimens were tested for influenza A/B virus and RSV using a reverse-transcriptase polymerase chain reaction (RT-PCR). RESULTS: Twenty-six (7.3%) had RT-PCR positive for influenza and 104 (29.4%) for RSV from 354 infants. Clinical diagnoses included pneumonia (73.4%), bronchiolitis (17.55%), croup (6.5%) and bronchitis (2.5%) and were similar among groups except the proportion of croup was significantly lower in RSV (p = .018). The proportion of RSV infection was highest between July and October (42-76%). RSV patients were more likely to present with higher temperature than the negative RT-PCR patients (p = .031). Oseltamivir was prescribed in 7.7% of influenza infections. Intravenous antibiotics were prescribed in 69.2%, 56.7% and 60.7% of the influenza, RSV and negative group respectively (p = .736). Percentages of patients requiring mechanical ventilation were 3.8, 6.7 and 6.3% among the influenza, RSV and negative group respectively (p = .861). Three patients died: 2 from RSV and 1 from the negative group. All three fatality cases had existing co-morbidity. CONCLUSION: A high proportion of RSV was detected in infants hospitalized with LRTI especially during July to October. High proportion of antibiotic prescription and relatively low rate of oseltamivir treatment were identified. Surveillance data and the availability of a rapid and reliable viral diagnostic test may help guide treatment, thereby improve outcome of this vulnerable population. SN - 0125-2208 UR - https://www.unboundmedicine.com/medline/citation/22043771/Clinical_and_epidemiological_characteristics_of_respiratory_syncytial_virus_and_influenza_virus_associated_hospitalization_in_urban_Thai_infants_ DB - PRIME DP - Unbound Medicine ER -