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Changes in waist circumference and the incidence of acute myocardial infarction in middle-aged men and women.
PLoS One 2011; 6(10):e26849Plos

Abstract

BACKGROUND

Waist circumference (WC) measured at one point in time is positively associated with the risk of acute myocardial infarction (MI), but the association with changes in WC (DWC) is not clear. We investigated the association between DWC and the risk of MI in middle-aged men and women, and evaluated the influence from concurrent changes in BMI (DBMI).

METHODOLOGY/PRINCIPAL FINDINGS

Data on 38,593 participants from the Danish Diet, Cancer and Health study was analysed. Anthropometry was assessed in 1993-97 and 1999-02. Information on fatal and non-fatal MI was obtained from National Registers. Cases were validated by review of the medical records. Hazard ratios (HR) were calculated from Cox proportional hazard models with individuals considered at risk from 1999-02 until December 30 2009. During 8.4 years of follow-up, 1,041 incident cases of MI occurred. WC was positively associated with the risk of MI, but weakly after adjustment for BMI. DWC was not associated with the risk of MI (HR per 5 cm change = 1.01 (0.95, 1.09) with adjustment for covariates, baseline WC, BMI and DBMI). Associations with DWC were not notably different in sub-groups stratified according to baseline WC or DBMI, or when individuals with MI occurring within the first years of follow-up were excluded.

CONCLUSIONS/SIGNIFICANCE

WC was positively associated with the risk of MI in middle-aged men and women, but changes in WC were not. These findings suggest that a reduction in WC may be an insufficient target for prevention of MI in middle-aged men and women.

Authors+Show Affiliations

Institute of Preventive Medicine, Copenhagen University Hospital, Copenhagen, Denmark. tb@ipm.regionh.dkNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22046380

Citation

Berentzen, Tina Landsvig, et al. "Changes in Waist Circumference and the Incidence of Acute Myocardial Infarction in Middle-aged Men and Women." PloS One, vol. 6, no. 10, 2011, pp. e26849.
Berentzen TL, Jakobsen MU, Stegger JG, et al. Changes in waist circumference and the incidence of acute myocardial infarction in middle-aged men and women. PLoS ONE. 2011;6(10):e26849.
Berentzen, T. L., Jakobsen, M. U., Stegger, J. G., Halkjaer, J., Tjønneland, A., Sørensen, T. I., & Overvad, K. (2011). Changes in waist circumference and the incidence of acute myocardial infarction in middle-aged men and women. PloS One, 6(10), pp. e26849. doi:10.1371/journal.pone.0026849.
Berentzen TL, et al. Changes in Waist Circumference and the Incidence of Acute Myocardial Infarction in Middle-aged Men and Women. PLoS ONE. 2011;6(10):e26849. PubMed PMID: 22046380.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Changes in waist circumference and the incidence of acute myocardial infarction in middle-aged men and women. AU - Berentzen,Tina Landsvig, AU - Jakobsen,Marianne Uhre, AU - Stegger,Jakob Gerhard, AU - Halkjaer,Jytte, AU - Tjønneland,Anne, AU - Sørensen,Thorkild I A, AU - Overvad,Kim, Y1 - 2011/10/26/ PY - 2011/09/01/received PY - 2011/10/04/accepted PY - 2011/11/3/entrez PY - 2011/11/3/pubmed PY - 2012/3/27/medline SP - e26849 EP - e26849 JF - PloS one JO - PLoS ONE VL - 6 IS - 10 N2 - BACKGROUND: Waist circumference (WC) measured at one point in time is positively associated with the risk of acute myocardial infarction (MI), but the association with changes in WC (DWC) is not clear. We investigated the association between DWC and the risk of MI in middle-aged men and women, and evaluated the influence from concurrent changes in BMI (DBMI). METHODOLOGY/PRINCIPAL FINDINGS: Data on 38,593 participants from the Danish Diet, Cancer and Health study was analysed. Anthropometry was assessed in 1993-97 and 1999-02. Information on fatal and non-fatal MI was obtained from National Registers. Cases were validated by review of the medical records. Hazard ratios (HR) were calculated from Cox proportional hazard models with individuals considered at risk from 1999-02 until December 30 2009. During 8.4 years of follow-up, 1,041 incident cases of MI occurred. WC was positively associated with the risk of MI, but weakly after adjustment for BMI. DWC was not associated with the risk of MI (HR per 5 cm change = 1.01 (0.95, 1.09) with adjustment for covariates, baseline WC, BMI and DBMI). Associations with DWC were not notably different in sub-groups stratified according to baseline WC or DBMI, or when individuals with MI occurring within the first years of follow-up were excluded. CONCLUSIONS/SIGNIFICANCE: WC was positively associated with the risk of MI in middle-aged men and women, but changes in WC were not. These findings suggest that a reduction in WC may be an insufficient target for prevention of MI in middle-aged men and women. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/22046380/Changes_in_waist_circumference_and_the_incidence_of_acute_myocardial_infarction_in_middle_aged_men_and_women_ L2 - http://dx.plos.org/10.1371/journal.pone.0026849 DB - PRIME DP - Unbound Medicine ER -