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Intrauterine injection of human chorionic gonadotropin before embryo transfer significantly improves the implantation and pregnancy rates in in vitro fertilization/intracytoplasmic sperm injection: a prospective randomized study.
Fertil Steril. 2011 Dec; 96(6):1370-1374.e1.FS

Abstract

OBJECTIVE

To investigate the value of intrauterine injection of human chorionic gonadotropin (hCG) before embryo transfer (ET).

DESIGN

Prospective randomized study.

SETTING

The Egyptian IVF-ET Center.

PATIENT(S)

Infertility patients younger than 40 years undergoing their first in vitro fertilization/intracytoplasmic sperm injection (IVF-ICSI).

INTERVENTION(S)

The study group (n = 167) received either 100 IU of hCG (n = 83), or 200 IU of hCG (n = 84) via intrauterine administration before ET. The control group (n = 93) underwent ET without hCG. After the interim analysis, the modified study group (n = 107) received intrauterine injection of 500 IU of hCG, and the control group (n = 105) underwent ET without hCG.

MAIN OUTCOME MEASURE(S)

Clinical pregnancy rate (PR) and implantation rate (IR).

RESULT(S)

The IR and PR were statistically significantly higher in the 500 hCG group (41.6% and 75%, respectively) as compared with the control group (29.5% and 60%, respectively). The IR and PR were 26.6% and 54% in the 100 hCG group, 28.3% and 57% in the 200 IU hCG group, and 29.4% and 60% in the control group, respectively, with no statistically significant difference.

CONCLUSION(S)

Intrauterine injection of 500 IU of hCG before ET statistically significantly improved the implantation and pregnancy rates in IVF/ICSI. CLINICAL TRIALS.GOV NUMBER: NCT 01030393.

Authors+Show Affiliations

The Egyptian IVF-ET Center, Cairo, Egypt. ragaa.mansour@gmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

22047664

Citation

Mansour, Ragaa, et al. "Intrauterine Injection of Human Chorionic Gonadotropin Before Embryo Transfer Significantly Improves the Implantation and Pregnancy Rates in in Vitro Fertilization/intracytoplasmic Sperm Injection: a Prospective Randomized Study." Fertility and Sterility, vol. 96, no. 6, 2011, pp. 1370-1374.e1.
Mansour R, Tawab N, Kamal O, et al. Intrauterine injection of human chorionic gonadotropin before embryo transfer significantly improves the implantation and pregnancy rates in in vitro fertilization/intracytoplasmic sperm injection: a prospective randomized study. Fertil Steril. 2011;96(6):1370-1374.e1.
Mansour, R., Tawab, N., Kamal, O., El-Faissal, Y., Serour, A., Aboulghar, M., & Serour, G. (2011). Intrauterine injection of human chorionic gonadotropin before embryo transfer significantly improves the implantation and pregnancy rates in in vitro fertilization/intracytoplasmic sperm injection: a prospective randomized study. Fertility and Sterility, 96(6), 1370-e1. https://doi.org/10.1016/j.fertnstert.2011.09.044
Mansour R, et al. Intrauterine Injection of Human Chorionic Gonadotropin Before Embryo Transfer Significantly Improves the Implantation and Pregnancy Rates in in Vitro Fertilization/intracytoplasmic Sperm Injection: a Prospective Randomized Study. Fertil Steril. 2011;96(6):1370-1374.e1. PubMed PMID: 22047664.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intrauterine injection of human chorionic gonadotropin before embryo transfer significantly improves the implantation and pregnancy rates in in vitro fertilization/intracytoplasmic sperm injection: a prospective randomized study. AU - Mansour,Ragaa, AU - Tawab,Nevine, AU - Kamal,Omnia, AU - El-Faissal,Yahia, AU - Serour,Ahmed, AU - Aboulghar,Mohamed, AU - Serour,Gamal, Y1 - 2011/11/01/ PY - 2011/06/29/received PY - 2011/08/16/revised PY - 2011/09/26/accepted PY - 2011/11/4/entrez PY - 2011/11/4/pubmed PY - 2012/1/24/medline SP - 1370 EP - 1374.e1 JF - Fertility and sterility JO - Fertil Steril VL - 96 IS - 6 N2 - OBJECTIVE: To investigate the value of intrauterine injection of human chorionic gonadotropin (hCG) before embryo transfer (ET). DESIGN: Prospective randomized study. SETTING: The Egyptian IVF-ET Center. PATIENT(S): Infertility patients younger than 40 years undergoing their first in vitro fertilization/intracytoplasmic sperm injection (IVF-ICSI). INTERVENTION(S): The study group (n = 167) received either 100 IU of hCG (n = 83), or 200 IU of hCG (n = 84) via intrauterine administration before ET. The control group (n = 93) underwent ET without hCG. After the interim analysis, the modified study group (n = 107) received intrauterine injection of 500 IU of hCG, and the control group (n = 105) underwent ET without hCG. MAIN OUTCOME MEASURE(S): Clinical pregnancy rate (PR) and implantation rate (IR). RESULT(S): The IR and PR were statistically significantly higher in the 500 hCG group (41.6% and 75%, respectively) as compared with the control group (29.5% and 60%, respectively). The IR and PR were 26.6% and 54% in the 100 hCG group, 28.3% and 57% in the 200 IU hCG group, and 29.4% and 60% in the control group, respectively, with no statistically significant difference. CONCLUSION(S): Intrauterine injection of 500 IU of hCG before ET statistically significantly improved the implantation and pregnancy rates in IVF/ICSI. CLINICAL TRIALS.GOV NUMBER: NCT 01030393. SN - 1556-5653 UR - https://www.unboundmedicine.com/medline/citation/22047664/Intrauterine_injection_of_human_chorionic_gonadotropin_before_embryo_transfer_significantly_improves_the_implantation_and_pregnancy_rates_in_in_vitro_fertilization/intracytoplasmic_sperm_injection:_a_prospective_randomized_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0015-0282(11)02619-7 DB - PRIME DP - Unbound Medicine ER -