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pH-responsive interpenetrating network hydrogel beads of poly(acrylamide)-g-carrageenan and sodium alginate for intestinal targeted drug delivery: synthesis, in vitro and in vivo evaluation.
J Colloid Interface Sci. 2012 Feb 01; 367(1):509-17.JC

Abstract

In the present work, we synthesized pH-responsive interpenetrating network (IPN) hydrogel beads of polyacrylamide grafted κ-carrageenan (PAAm-g-CG) and sodium alginate (SA) for targeting ketoprofen to the intestine. The PAAm-g-CG was synthesized by free radical polymerization followed by alkaline hydrolysis under nitrogen gas. The PAAm-g-CG was characterized by elemental analysis, FTIR spectroscopy and thermogravimetric analysis (TGA). The drug-loaded IPN hydrogel beads were prepared by simple ionotropic gelation/covalent crosslinking method. The amorphous nature of drug in the beads was confirmed by differential scanning calorimetry and X-ray diffraction studies. The spherical shape of the beads was confirmed by scanning electron microscopic analysis. The beads exhibited ample pH-responsive behavior in the pulsatile swelling study. The ketoprofen release was significantly increased when pH of the medium was changed from acidic to alkaline. The beads showed maximum of 10% drug release in acidic medium of pH 1.2, and about 90% drug release was recorded in alkaline medium of pH 7.4. Stomach histopathology of albino rats indicated that the prepared beads were able to retard the drug release in stomach leading to the reduced ulceration, hemorrhage and erosion of gastric mucosa.

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Authors+Show Affiliations

Kulkarni RV
Department of Pharmaceutics, BLDEA's College of Pharmacy, BLDE University Campus, Bijapur 586 103, Karnataka, India. pharma_75raghu@yahoo.com
Boppana R
No affiliation info available
Krishna Mohan G
No affiliation info available
Mutalik S
No affiliation info available
Kalyane NV
No affiliation info available

MeSH

AcrylamidesAlginatesAnimalsAnti-Inflammatory Agents, Non-SteroidalCarrageenanDelayed-Action PreparationsGlucuronic AcidHexuronic AcidsHydrogel, Polyethylene Glycol DimethacrylateHydrogen-Ion ConcentrationIntestinal MucosaKetoprofenMaleRats

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22047923

Citation

Kulkarni, Raghavendra V., et al. "PH-responsive Interpenetrating Network Hydrogel Beads of Poly(acrylamide)-g-carrageenan and Sodium Alginate for Intestinal Targeted Drug Delivery: Synthesis, in Vitro and in Vivo Evaluation." Journal of Colloid and Interface Science, vol. 367, no. 1, 2012, pp. 509-17.
Kulkarni RV, Boppana R, Krishna Mohan G, et al. PH-responsive interpenetrating network hydrogel beads of poly(acrylamide)-g-carrageenan and sodium alginate for intestinal targeted drug delivery: synthesis, in vitro and in vivo evaluation. J Colloid Interface Sci. 2012;367(1):509-17.
Kulkarni, R. V., Boppana, R., Krishna Mohan, G., Mutalik, S., & Kalyane, N. V. (2012). PH-responsive interpenetrating network hydrogel beads of poly(acrylamide)-g-carrageenan and sodium alginate for intestinal targeted drug delivery: synthesis, in vitro and in vivo evaluation. Journal of Colloid and Interface Science, 367(1), 509-17. https://doi.org/10.1016/j.jcis.2011.10.025
Kulkarni RV, et al. PH-responsive Interpenetrating Network Hydrogel Beads of Poly(acrylamide)-g-carrageenan and Sodium Alginate for Intestinal Targeted Drug Delivery: Synthesis, in Vitro and in Vivo Evaluation. J Colloid Interface Sci. 2012 Feb 1;367(1):509-17. PubMed PMID: 22047923.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - pH-responsive interpenetrating network hydrogel beads of poly(acrylamide)-g-carrageenan and sodium alginate for intestinal targeted drug delivery: synthesis, in vitro and in vivo evaluation. AU - Kulkarni,Raghavendra V, AU - Boppana,Rashmi, AU - Krishna Mohan,G, AU - Mutalik,Srinivas, AU - Kalyane,Navanath V, Y1 - 2011/10/19/ PY - 2011/07/15/received PY - 2011/10/07/revised PY - 2011/10/08/accepted PY - 2011/11/4/entrez PY - 2011/11/4/pubmed PY - 2012/4/14/medline SP - 509 EP - 17 JF - Journal of colloid and interface science JO - J Colloid Interface Sci VL - 367 IS - 1 N2 - In the present work, we synthesized pH-responsive interpenetrating network (IPN) hydrogel beads of polyacrylamide grafted κ-carrageenan (PAAm-g-CG) and sodium alginate (SA) for targeting ketoprofen to the intestine. The PAAm-g-CG was synthesized by free radical polymerization followed by alkaline hydrolysis under nitrogen gas. The PAAm-g-CG was characterized by elemental analysis, FTIR spectroscopy and thermogravimetric analysis (TGA). The drug-loaded IPN hydrogel beads were prepared by simple ionotropic gelation/covalent crosslinking method. The amorphous nature of drug in the beads was confirmed by differential scanning calorimetry and X-ray diffraction studies. The spherical shape of the beads was confirmed by scanning electron microscopic analysis. The beads exhibited ample pH-responsive behavior in the pulsatile swelling study. The ketoprofen release was significantly increased when pH of the medium was changed from acidic to alkaline. The beads showed maximum of 10% drug release in acidic medium of pH 1.2, and about 90% drug release was recorded in alkaline medium of pH 7.4. Stomach histopathology of albino rats indicated that the prepared beads were able to retard the drug release in stomach leading to the reduced ulceration, hemorrhage and erosion of gastric mucosa. SN - 1095-7103 UR - https://www.unboundmedicine.com/medline/citation/22047923/pH_responsive_interpenetrating_network_hydrogel_beads_of_poly_acrylamide__g_carrageenan_and_sodium_alginate_for_intestinal_targeted_drug_delivery:_synthesis_in_vitro_and_in_vivo_evaluation_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0021-9797(11)01277-X DB - PRIME DP - Unbound Medicine ER -
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