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A comparative study of hepatitis caused by scrub typhus and viral hepatitis A in South Korea.
Am J Trop Med Hyg. 2011 Nov; 85(5):873-7.AJ

Abstract

We compared clinical features and laboratory findings of 104 patients with hepatitis A and 197 patients with scrub typhus. Nausea, vomiting, abdominal pain, hepatomegaly, and jaundice were common in patient with hepatitis A, and fever and headache were significantly more common in patients with scrub typhus. At presentation, an alanine aminotransferase (ALT) level ≥ 500 U/L was observed in 1% of scrub typhus patients and in 87.5% of hepatitis A patients (P < 0.001). A bilirubin level ≥ 1.3 mg/dL was observed in 16.8% of scrub typhus patients and 90.4% of hepatitis A patients. The ALT:lactate dehydrogenase ratio was ≤ 5 in 97.4% of the patients with scrub typhus and > 5 in 95.2% of those with hepatitis A (P < 0.001). Fever, headache, rash, and eschar are findings that indicate scrub typhus. An ALT level ≥ 500 U/L (adjusted odds ratio = 0.011) a bilirubin level ≥ 1.3 (adjusted odds ratio = 0.024), an ALT:lactate dehydrogenase ratio > 5, and hepatomegaly are indications of viral hepatitis A.

Authors+Show Affiliations

Department of Internal Medicine, Research Center for Resistant Cells, School of Medicine, Chosun University, Gwangju, South Korea. joon3640@hanmail.netNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

22049041

Citation

Lee, Jun, et al. "A Comparative Study of Hepatitis Caused By Scrub Typhus and Viral Hepatitis a in South Korea." The American Journal of Tropical Medicine and Hygiene, vol. 85, no. 5, 2011, pp. 873-7.
Lee J, Kim DM, Yun NR, et al. A comparative study of hepatitis caused by scrub typhus and viral hepatitis A in South Korea. Am J Trop Med Hyg. 2011;85(5):873-7.
Lee, J., Kim, D. M., Yun, N. R., Byeon, Y. M., Kim, Y. D., Park, C. G., Kim, M. W., & Han, M. A. (2011). A comparative study of hepatitis caused by scrub typhus and viral hepatitis A in South Korea. The American Journal of Tropical Medicine and Hygiene, 85(5), 873-7. https://doi.org/10.4269/ajtmh.2011.09-0703
Lee J, et al. A Comparative Study of Hepatitis Caused By Scrub Typhus and Viral Hepatitis a in South Korea. Am J Trop Med Hyg. 2011;85(5):873-7. PubMed PMID: 22049041.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A comparative study of hepatitis caused by scrub typhus and viral hepatitis A in South Korea. AU - Lee,Jun, AU - Kim,Dong-Min, AU - Yun,Na Ra, AU - Byeon,Yu Mi, AU - Kim,Young Dae, AU - Park,Chan Guk, AU - Kim,Man Woo, AU - Han,Mi Ah, PY - 2011/11/4/entrez PY - 2011/11/4/pubmed PY - 2011/12/23/medline SP - 873 EP - 7 JF - The American journal of tropical medicine and hygiene JO - Am J Trop Med Hyg VL - 85 IS - 5 N2 - We compared clinical features and laboratory findings of 104 patients with hepatitis A and 197 patients with scrub typhus. Nausea, vomiting, abdominal pain, hepatomegaly, and jaundice were common in patient with hepatitis A, and fever and headache were significantly more common in patients with scrub typhus. At presentation, an alanine aminotransferase (ALT) level ≥ 500 U/L was observed in 1% of scrub typhus patients and in 87.5% of hepatitis A patients (P < 0.001). A bilirubin level ≥ 1.3 mg/dL was observed in 16.8% of scrub typhus patients and 90.4% of hepatitis A patients. The ALT:lactate dehydrogenase ratio was ≤ 5 in 97.4% of the patients with scrub typhus and > 5 in 95.2% of those with hepatitis A (P < 0.001). Fever, headache, rash, and eschar are findings that indicate scrub typhus. An ALT level ≥ 500 U/L (adjusted odds ratio = 0.011) a bilirubin level ≥ 1.3 (adjusted odds ratio = 0.024), an ALT:lactate dehydrogenase ratio > 5, and hepatomegaly are indications of viral hepatitis A. SN - 1476-1645 UR - https://www.unboundmedicine.com/medline/citation/22049041/A_comparative_study_of_hepatitis_caused_by_scrub_typhus_and_viral_hepatitis_A_in_South_Korea_ L2 - https://ajtmh.org/doi/10.4269/ajtmh.2011.09-0703 DB - PRIME DP - Unbound Medicine ER -