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Early-life exposures and early-onset uterine leiomyomata in black women in the Sister Study.

Abstract

BACKGROUND

Uterine leiomyomata (fibroids) are hormonally responsive tumors, but little is known about risk factors. Early-life exposures may influence uterine development and subsequent response to hormones in adulthood. An earlier analysis of non-Hispanic white women who participated in the Sister Study found associations between several early-life factors and early-onset fibroids.

OBJECTIVES

We evaluated associations of early-life and childhood exposures with early-onset fibroids among black women and compared the results with those found among white women.

METHODS

We analyzed baseline data from 3,534 black women, 35-59 years of age, in the Sister Study (a nationwide cohort of women who had a sister diagnosed with breast cancer) who self-reported information on early-life and childhood exposures. Early-onset fibroids were assessed based on self-report of a physician diagnosis of fibroids by the age of 30 years (n = 561). We estimated risk ratios (RR) and 95% confidence intervals (CI) from log-binomial regression models.

RESULTS

Factors most strongly associated with early-onset fibroids were in utero diethylstilbestrol (DES; RR = 2.02; 95% CI: 1.28, 3.18), maternal prepregnancy diabetes or gestational diabetes (RR = 1.54; 95% CI: 0.95, 2.49), and monozygotic multiple birth (RR = 1.94; 95% CI: 1.26, 2.99). We also found positive associations with having been taller or thinner than peers at the age of 10 years and with early-life factors that included being the firstborn child of a teenage mother, maternal hypertensive disorder, preterm birth, and having been fed soy formula.

CONCLUSIONS

With the exception of monozygotic multiple birth and maternal hypertensive disorder, early-life risk factors for early-onset fibroids for black women were similar to those found for white women. However, in contrast to whites, childhood height and weight, but not low socioeconomic status indicators, were associated with early-onset fibroids in blacks. The general consistency of early-life findings for black and white women supports a possible role of early-life factors in fibroid development.

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  • Authors+Show Affiliations

    ,

    Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA. daloisio@niehs.nih.gov

    , ,

    Source

    Environmental health perspectives 120:3 2012 Mar pg 406-12

    MeSH

    Adult
    African Americans
    Cohort Studies
    Female
    Humans
    Leiomyoma
    Maternal Exposure
    Middle Aged
    Odds Ratio
    Pregnancy
    Prenatal Exposure Delayed Effects
    Prospective Studies
    Puerto Rico
    Risk Factors
    Siblings
    Time Factors
    United States
    Uterine Neoplasms

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Intramural

    Language

    eng

    PubMed ID

    22049383

    Citation

    D'Aloisio, Aimee A., et al. "Early-life Exposures and Early-onset Uterine Leiomyomata in Black Women in the Sister Study." Environmental Health Perspectives, vol. 120, no. 3, 2012, pp. 406-12.
    D'Aloisio AA, Baird DD, DeRoo LA, et al. Early-life exposures and early-onset uterine leiomyomata in black women in the Sister Study. Environ Health Perspect. 2012;120(3):406-12.
    D'Aloisio, A. A., Baird, D. D., DeRoo, L. A., & Sandler, D. P. (2012). Early-life exposures and early-onset uterine leiomyomata in black women in the Sister Study. Environmental Health Perspectives, 120(3), pp. 406-12. doi:10.1289/ehp.1103620.
    D'Aloisio AA, et al. Early-life Exposures and Early-onset Uterine Leiomyomata in Black Women in the Sister Study. Environ Health Perspect. 2012;120(3):406-12. PubMed PMID: 22049383.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Early-life exposures and early-onset uterine leiomyomata in black women in the Sister Study. AU - D'Aloisio,Aimee A, AU - Baird,Donna D, AU - DeRoo,Lisa A, AU - Sandler,Dale P, Y1 - 2011/11/02/ PY - 2011/03/01/received PY - 2011/11/02/accepted PY - 2011/11/4/entrez PY - 2011/11/4/pubmed PY - 2012/6/27/medline SP - 406 EP - 12 JF - Environmental health perspectives JO - Environ. Health Perspect. VL - 120 IS - 3 N2 - BACKGROUND: Uterine leiomyomata (fibroids) are hormonally responsive tumors, but little is known about risk factors. Early-life exposures may influence uterine development and subsequent response to hormones in adulthood. An earlier analysis of non-Hispanic white women who participated in the Sister Study found associations between several early-life factors and early-onset fibroids. OBJECTIVES: We evaluated associations of early-life and childhood exposures with early-onset fibroids among black women and compared the results with those found among white women. METHODS: We analyzed baseline data from 3,534 black women, 35-59 years of age, in the Sister Study (a nationwide cohort of women who had a sister diagnosed with breast cancer) who self-reported information on early-life and childhood exposures. Early-onset fibroids were assessed based on self-report of a physician diagnosis of fibroids by the age of 30 years (n = 561). We estimated risk ratios (RR) and 95% confidence intervals (CI) from log-binomial regression models. RESULTS: Factors most strongly associated with early-onset fibroids were in utero diethylstilbestrol (DES; RR = 2.02; 95% CI: 1.28, 3.18), maternal prepregnancy diabetes or gestational diabetes (RR = 1.54; 95% CI: 0.95, 2.49), and monozygotic multiple birth (RR = 1.94; 95% CI: 1.26, 2.99). We also found positive associations with having been taller or thinner than peers at the age of 10 years and with early-life factors that included being the firstborn child of a teenage mother, maternal hypertensive disorder, preterm birth, and having been fed soy formula. CONCLUSIONS: With the exception of monozygotic multiple birth and maternal hypertensive disorder, early-life risk factors for early-onset fibroids for black women were similar to those found for white women. However, in contrast to whites, childhood height and weight, but not low socioeconomic status indicators, were associated with early-onset fibroids in blacks. The general consistency of early-life findings for black and white women supports a possible role of early-life factors in fibroid development. SN - 1552-9924 UR - https://www.unboundmedicine.com/medline/citation/22049383/Early_life_exposures_and_early_onset_uterine_leiomyomata_in_black_women_in_the_Sister_Study_ L2 - https://ehp.niehs.nih.gov/doi/full/10.1289/ehp.1103620?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -