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Serum uric acid is related to cardiovascular events and correlates with N-terminal pro-B-type natriuretic peptide and albuminuria in patients with diabetes mellitus.
Diabet Med. 2012 Jun; 29(6):721-5.DM

Abstract

BACKGROUND

Hyperuricemia is a risk factor for cardiovascular events and renal insufficiency. It correlates to intima-media thickness and microalbuminuria. In this study we evaluated uric acid as an independent marker for cardiac events in patients with diabetes.

METHODS

In a prospective observational study we recruited 494 patients with diabetes. Patients were then followed for 12.8 months (mean follow-up) and hospitalizations as a result of cardiac events (ischaemic heart disease, arrhythmias, heart failure) were recorded.

RESULTS

The median duration of diabetes was 11 ± 10.35 years. Patients were in the mean 60 ± 13 years old and mean HbA(1c) was 62 ± 13 mmol/mol (7.8 ± 3.3%). At baseline, mean uric acid was 321.2 ± 101.1 μmol/l (range 101.1-743.5 μmol/l), median N-terminal pro-B-type natriuretic peptide was 92 ± 412 pg/ml and median urinary albumin to creatinine ratio was 8 ± 361 mg/g; Uric acid significantly correlated to N-terminal pro-B-type natriuretic peptide (r = 0.237, P < 0.001) and urinary albumin:creatinine ratio (r = 0.198, P < 0.001). In a Cox regression model, including age, estimated glomerular filtration rate, gender, systolic blood pressure, smoking and alcohol consumption, uric acid was the best predictor of cardiac events (hazard ratio 1.331, confidence interval 1.095-1.616, P = 0.04). However, uric acid lost its prognostic value when the natural logarithm of N-terminal pro-B-type natriuretic peptide was added to the model.

CONCLUSION

Serum uric acid is a predictor of cardiac events and correlates to N-terminal pro-B-type natriuretic peptide and albuminuria, underscoring the importance of uric acid as a cardiovascular risk marker in patients with diabetes.

Authors+Show Affiliations

Department of Endocrinology, Medical University of Vienna, Vienna, Austria.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22050532

Citation

Resl, M, et al. "Serum Uric Acid Is Related to Cardiovascular Events and Correlates With N-terminal pro-B-type Natriuretic Peptide and Albuminuria in Patients With Diabetes Mellitus." Diabetic Medicine : a Journal of the British Diabetic Association, vol. 29, no. 6, 2012, pp. 721-5.
Resl M, Clodi M, Neuhold S, et al. Serum uric acid is related to cardiovascular events and correlates with N-terminal pro-B-type natriuretic peptide and albuminuria in patients with diabetes mellitus. Diabet Med. 2012;29(6):721-5.
Resl, M., Clodi, M., Neuhold, S., Kromoser, H., Riedl, M., Vila, G., Prager, R., Pacher, R., Strunk, G., Luger, A., & Hülsmann, M. (2012). Serum uric acid is related to cardiovascular events and correlates with N-terminal pro-B-type natriuretic peptide and albuminuria in patients with diabetes mellitus. Diabetic Medicine : a Journal of the British Diabetic Association, 29(6), 721-5. https://doi.org/10.1111/j.1464-5491.2011.03515.x
Resl M, et al. Serum Uric Acid Is Related to Cardiovascular Events and Correlates With N-terminal pro-B-type Natriuretic Peptide and Albuminuria in Patients With Diabetes Mellitus. Diabet Med. 2012;29(6):721-5. PubMed PMID: 22050532.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum uric acid is related to cardiovascular events and correlates with N-terminal pro-B-type natriuretic peptide and albuminuria in patients with diabetes mellitus. AU - Resl,M, AU - Clodi,M, AU - Neuhold,S, AU - Kromoser,H, AU - Riedl,M, AU - Vila,G, AU - Prager,R, AU - Pacher,R, AU - Strunk,G, AU - Luger,A, AU - Hülsmann,M, PY - 2011/11/5/entrez PY - 2011/11/5/pubmed PY - 2012/8/29/medline SP - 721 EP - 5 JF - Diabetic medicine : a journal of the British Diabetic Association JO - Diabet Med VL - 29 IS - 6 N2 - BACKGROUND: Hyperuricemia is a risk factor for cardiovascular events and renal insufficiency. It correlates to intima-media thickness and microalbuminuria. In this study we evaluated uric acid as an independent marker for cardiac events in patients with diabetes. METHODS: In a prospective observational study we recruited 494 patients with diabetes. Patients were then followed for 12.8 months (mean follow-up) and hospitalizations as a result of cardiac events (ischaemic heart disease, arrhythmias, heart failure) were recorded. RESULTS: The median duration of diabetes was 11 ± 10.35 years. Patients were in the mean 60 ± 13 years old and mean HbA(1c) was 62 ± 13 mmol/mol (7.8 ± 3.3%). At baseline, mean uric acid was 321.2 ± 101.1 μmol/l (range 101.1-743.5 μmol/l), median N-terminal pro-B-type natriuretic peptide was 92 ± 412 pg/ml and median urinary albumin to creatinine ratio was 8 ± 361 mg/g; Uric acid significantly correlated to N-terminal pro-B-type natriuretic peptide (r = 0.237, P < 0.001) and urinary albumin:creatinine ratio (r = 0.198, P < 0.001). In a Cox regression model, including age, estimated glomerular filtration rate, gender, systolic blood pressure, smoking and alcohol consumption, uric acid was the best predictor of cardiac events (hazard ratio 1.331, confidence interval 1.095-1.616, P = 0.04). However, uric acid lost its prognostic value when the natural logarithm of N-terminal pro-B-type natriuretic peptide was added to the model. CONCLUSION: Serum uric acid is a predictor of cardiac events and correlates to N-terminal pro-B-type natriuretic peptide and albuminuria, underscoring the importance of uric acid as a cardiovascular risk marker in patients with diabetes. SN - 1464-5491 UR - https://www.unboundmedicine.com/medline/citation/22050532/Serum_uric_acid_is_related_to_cardiovascular_events_and_correlates_with_N_terminal_pro_B_type_natriuretic_peptide_and_albuminuria_in_patients_with_diabetes_mellitus_ L2 - https://doi.org/10.1111/j.1464-5491.2011.03515.x DB - PRIME DP - Unbound Medicine ER -