Tags

Type your tag names separated by a space and hit enter

Anti-inflammatory phenolics isolated from Juniperus rigida leaves and twigs in lipopolysaccharide-stimulated RAW264.7 macrophage cells.
J Enzyme Inhib Med Chem. 2012 Dec; 27(6):875-9.JE

Abstract

Inflammation is an essential host defense system particularly in response to infection and injury; however, excessive or undesirable inflammatory responses contribute to acute and chronic human diseases. A high-throughput screening effort searching for anti-inflammatory compounds from medicinal plants deduced that the methanolic extract of Juniperus rigida S. et L. (Cupressaceae) inhibited significantly nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells. Activity-guided fractionation and isolation yielded 13 phenolic compounds, including one new phenylpropanoid glycosides, 3,4-dimethoxycinnamyl 9-O-β-D-glucopyranoside (1). Among the isolated compounds, phenylpropanoid glycosides with p-hydroxy group (2, 4) and massoniaside A (7), (+)-catechin (10), amentoflavone (11) effectively inhibited LPS-induced NO production in RAW264.7 cells.

Authors+Show Affiliations

College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University, Seoul, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22050541

Citation

Jeong, Eun Ju, et al. "Anti-inflammatory Phenolics Isolated From Juniperus Rigida Leaves and Twigs in Lipopolysaccharide-stimulated RAW264.7 Macrophage Cells." Journal of Enzyme Inhibition and Medicinal Chemistry, vol. 27, no. 6, 2012, pp. 875-9.
Jeong EJ, Seo H, Yang H, et al. Anti-inflammatory phenolics isolated from Juniperus rigida leaves and twigs in lipopolysaccharide-stimulated RAW264.7 macrophage cells. J Enzyme Inhib Med Chem. 2012;27(6):875-9.
Jeong, E. J., Seo, H., Yang, H., Kim, J., Sung, S. H., & Kim, Y. C. (2012). Anti-inflammatory phenolics isolated from Juniperus rigida leaves and twigs in lipopolysaccharide-stimulated RAW264.7 macrophage cells. Journal of Enzyme Inhibition and Medicinal Chemistry, 27(6), 875-9. https://doi.org/10.3109/14756366.2011.625025
Jeong EJ, et al. Anti-inflammatory Phenolics Isolated From Juniperus Rigida Leaves and Twigs in Lipopolysaccharide-stimulated RAW264.7 Macrophage Cells. J Enzyme Inhib Med Chem. 2012;27(6):875-9. PubMed PMID: 22050541.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti-inflammatory phenolics isolated from Juniperus rigida leaves and twigs in lipopolysaccharide-stimulated RAW264.7 macrophage cells. AU - Jeong,Eun Ju, AU - Seo,Hanee, AU - Yang,Heejung, AU - Kim,Jinwoong, AU - Sung,Sang Hyun, AU - Kim,Young Choong, Y1 - 2011/11/03/ PY - 2011/11/5/entrez PY - 2011/11/5/pubmed PY - 2013/6/6/medline SP - 875 EP - 9 JF - Journal of enzyme inhibition and medicinal chemistry JO - J Enzyme Inhib Med Chem VL - 27 IS - 6 N2 - Inflammation is an essential host defense system particularly in response to infection and injury; however, excessive or undesirable inflammatory responses contribute to acute and chronic human diseases. A high-throughput screening effort searching for anti-inflammatory compounds from medicinal plants deduced that the methanolic extract of Juniperus rigida S. et L. (Cupressaceae) inhibited significantly nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells. Activity-guided fractionation and isolation yielded 13 phenolic compounds, including one new phenylpropanoid glycosides, 3,4-dimethoxycinnamyl 9-O-β-D-glucopyranoside (1). Among the isolated compounds, phenylpropanoid glycosides with p-hydroxy group (2, 4) and massoniaside A (7), (+)-catechin (10), amentoflavone (11) effectively inhibited LPS-induced NO production in RAW264.7 cells. SN - 1475-6374 UR - https://www.unboundmedicine.com/medline/citation/22050541/Anti_inflammatory_phenolics_isolated_from_Juniperus_rigida_leaves_and_twigs_in_lipopolysaccharide_stimulated_RAW264_7_macrophage_cells_ L2 - https://www.tandfonline.com/doi/full/10.3109/14756366.2011.625025 DB - PRIME DP - Unbound Medicine ER -