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Biomonitoring of bisphenol A concentrations in maternal and umbilical cord blood in regard to birth outcomes and adipokine expression: a birth cohort study in Taiwan.
Environ Health. 2011 Nov 03; 10:94.EH

Abstract

BACKGROUND

Bisphenol A (BPA) is a sealant and flux of plastic materials and has been determined to be an endocrine-disrupting chemical. Prenatal exposure to BPA can lead to substantial adverse effects on fetal growth and development. This study was conducted to assess BPA concentration in pregnant women and umbilical cord blood, and to investigate whether maternal BPA exposure affected fetal outcomes including lower birth weight (LBW), smaller size for gestational age (SGA), and high leptin (HLP) and low adiponectin (LAD) secretion.

METHODS

We measured the BPA levels of maternal blood (n = 97) and umbilical cord blood (n = 97) with a high-performance liquid chromatography/UV detector. The protein secretion of leptin and adiponectin were separately determined using enzyme-linked immunosorbent assay. A logistic regression was performed to estimate the effects of maternal exposure to BPA on LBW, SGA, and adverse action of adipokines in newborns.

RESULTS

The geometric means of BPA concentration in maternal blood and fetal cord blood were 2.5 ng/ml and 0.5 ng/ml, respectively. Elevated risks of LBW (OR 2.42, 95% confidence interval (CI) 1.72-3.36), SGA (OR 2.01, 95% CI 1.39-3.01), and adverse action of leptin (OR 1.67, 95% CI 1.12-2.25) and adiponectin (OR 1.25, 95% CI 1.52-3.97) were observed in male neonates in the highest quartile of maternal BPA exposure.

CONCLUSIONS

Elevated prenatal BPA exposure increased the risk of LBW, SGA, and adverse actions of adipokines in neonates, especially in male infants. These results provide further evidence that maternal exposure is correlated with adverse birth outcomes.

Authors+Show Affiliations

Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22050967

Citation

Chou, Wei-Chun, et al. "Biomonitoring of Bisphenol a Concentrations in Maternal and Umbilical Cord Blood in Regard to Birth Outcomes and Adipokine Expression: a Birth Cohort Study in Taiwan." Environmental Health : a Global Access Science Source, vol. 10, 2011, p. 94.
Chou WC, Chen JL, Lin CF, et al. Biomonitoring of bisphenol A concentrations in maternal and umbilical cord blood in regard to birth outcomes and adipokine expression: a birth cohort study in Taiwan. Environ Health. 2011;10:94.
Chou, W. C., Chen, J. L., Lin, C. F., Chen, Y. C., Shih, F. C., & Chuang, C. Y. (2011). Biomonitoring of bisphenol A concentrations in maternal and umbilical cord blood in regard to birth outcomes and adipokine expression: a birth cohort study in Taiwan. Environmental Health : a Global Access Science Source, 10, 94. https://doi.org/10.1186/1476-069X-10-94
Chou WC, et al. Biomonitoring of Bisphenol a Concentrations in Maternal and Umbilical Cord Blood in Regard to Birth Outcomes and Adipokine Expression: a Birth Cohort Study in Taiwan. Environ Health. 2011 Nov 3;10:94. PubMed PMID: 22050967.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Biomonitoring of bisphenol A concentrations in maternal and umbilical cord blood in regard to birth outcomes and adipokine expression: a birth cohort study in Taiwan. AU - Chou,Wei-Chun, AU - Chen,Jyh-Larng, AU - Lin,Chung-Fen, AU - Chen,Yi-Chun, AU - Shih,Feng-Cheng, AU - Chuang,Chun-Yu, Y1 - 2011/11/03/ PY - 2011/02/09/received PY - 2011/11/03/accepted PY - 2011/11/5/entrez PY - 2011/11/5/pubmed PY - 2012/3/22/medline SP - 94 EP - 94 JF - Environmental health : a global access science source JO - Environ Health VL - 10 N2 - BACKGROUND: Bisphenol A (BPA) is a sealant and flux of plastic materials and has been determined to be an endocrine-disrupting chemical. Prenatal exposure to BPA can lead to substantial adverse effects on fetal growth and development. This study was conducted to assess BPA concentration in pregnant women and umbilical cord blood, and to investigate whether maternal BPA exposure affected fetal outcomes including lower birth weight (LBW), smaller size for gestational age (SGA), and high leptin (HLP) and low adiponectin (LAD) secretion. METHODS: We measured the BPA levels of maternal blood (n = 97) and umbilical cord blood (n = 97) with a high-performance liquid chromatography/UV detector. The protein secretion of leptin and adiponectin were separately determined using enzyme-linked immunosorbent assay. A logistic regression was performed to estimate the effects of maternal exposure to BPA on LBW, SGA, and adverse action of adipokines in newborns. RESULTS: The geometric means of BPA concentration in maternal blood and fetal cord blood were 2.5 ng/ml and 0.5 ng/ml, respectively. Elevated risks of LBW (OR 2.42, 95% confidence interval (CI) 1.72-3.36), SGA (OR 2.01, 95% CI 1.39-3.01), and adverse action of leptin (OR 1.67, 95% CI 1.12-2.25) and adiponectin (OR 1.25, 95% CI 1.52-3.97) were observed in male neonates in the highest quartile of maternal BPA exposure. CONCLUSIONS: Elevated prenatal BPA exposure increased the risk of LBW, SGA, and adverse actions of adipokines in neonates, especially in male infants. These results provide further evidence that maternal exposure is correlated with adverse birth outcomes. SN - 1476-069X UR - https://www.unboundmedicine.com/medline/citation/22050967/Biomonitoring_of_bisphenol_A_concentrations_in_maternal_and_umbilical_cord_blood_in_regard_to_birth_outcomes_and_adipokine_expression:_a_birth_cohort_study_in_Taiwan_ L2 - https://ehjournal.biomedcentral.com/articles/10.1186/1476-069X-10-94 DB - PRIME DP - Unbound Medicine ER -