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Efficacy of albendazole combined with a marine fungal extract (m2-9) against Angiostrongylus cantonensis-induced meningitis in mice.
J Helminthol. 2012 Dec; 86(4):410-7.JH

Abstract

The pathogenesis of angiostrongyliasis, resulting from Angiostrongylus cantonensis invasion of the human central nervous system, remains elusive. Anthelmintics are usually used to kill worms, although dead worms in the brain may cause severe inflammation which will lead to central nervous system damage. Therefore, combination therapy with anthelmintics and anti-inflammatory drugs in the treatment of human angiostrongyliasis needs further study. To evaluate the efficacy of albendazole combined with a marine fungal extract (m2-9) in A. cantonensis infection, BALB/c mice infected by the third-stage larvae of A. cantonensis were divided into three groups: mice treated with albendazole or m2-9 alone or in combination from day 5 post-inoculation (PI). Several efficacy parameters were recorded, including weight change, worm recovery, neurological function, behavioural analysis, eosinophil and leucocyte counts. The results showed that combination therapy increased body weight, reduced worm burden, improved learning ability, memory and action, decreased neurological dysfunction and leucocyte response in these mice. The combination of albendazole and m2-9 treatment significantly decreased leucocyte response and increased the frequency of rearing, compared to infected mice treated with either drug alone. Therefore, m2-9 is a natural product with potentially significant therapeutic value for angiostrongyliasis and is worthy of further study.

Authors+Show Affiliations

Key Laboratory of Tropical Diseases and Control of the Ministry of Education, Guangzhou, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22050968

Citation

Li, Z-Y, et al. "Efficacy of Albendazole Combined With a Marine Fungal Extract (m2-9) Against Angiostrongylus Cantonensis-induced Meningitis in Mice." Journal of Helminthology, vol. 86, no. 4, 2012, pp. 410-7.
Li ZY, Sun R, Li J, et al. Efficacy of albendazole combined with a marine fungal extract (m2-9) against Angiostrongylus cantonensis-induced meningitis in mice. J Helminthol. 2012;86(4):410-7.
Li, Z. Y., Sun, R., Li, J., Song, Y. X., Lin, Y. C., Zeng, X., He, H. J., Wei, J., Yang, F., Zheng, H. Q., Lv, Z. Y., & Wu, Z. D. (2012). Efficacy of albendazole combined with a marine fungal extract (m2-9) against Angiostrongylus cantonensis-induced meningitis in mice. Journal of Helminthology, 86(4), 410-7. https://doi.org/10.1017/S0022149X11000630
Li ZY, et al. Efficacy of Albendazole Combined With a Marine Fungal Extract (m2-9) Against Angiostrongylus Cantonensis-induced Meningitis in Mice. J Helminthol. 2012;86(4):410-7. PubMed PMID: 22050968.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Efficacy of albendazole combined with a marine fungal extract (m2-9) against Angiostrongylus cantonensis-induced meningitis in mice. AU - Li,Z-Y, AU - Sun,R, AU - Li,J, AU - Song,Y-X, AU - Lin,Y-C, AU - Zeng,X, AU - He,H-J, AU - Wei,J, AU - Yang,F, AU - Zheng,H-Q, AU - Lv,Z-Y, AU - Wu,Z-D, Y1 - 2011/11/04/ PY - 2011/11/5/entrez PY - 2011/11/5/pubmed PY - 2013/4/6/medline SP - 410 EP - 7 JF - Journal of helminthology JO - J Helminthol VL - 86 IS - 4 N2 - The pathogenesis of angiostrongyliasis, resulting from Angiostrongylus cantonensis invasion of the human central nervous system, remains elusive. Anthelmintics are usually used to kill worms, although dead worms in the brain may cause severe inflammation which will lead to central nervous system damage. Therefore, combination therapy with anthelmintics and anti-inflammatory drugs in the treatment of human angiostrongyliasis needs further study. To evaluate the efficacy of albendazole combined with a marine fungal extract (m2-9) in A. cantonensis infection, BALB/c mice infected by the third-stage larvae of A. cantonensis were divided into three groups: mice treated with albendazole or m2-9 alone or in combination from day 5 post-inoculation (PI). Several efficacy parameters were recorded, including weight change, worm recovery, neurological function, behavioural analysis, eosinophil and leucocyte counts. The results showed that combination therapy increased body weight, reduced worm burden, improved learning ability, memory and action, decreased neurological dysfunction and leucocyte response in these mice. The combination of albendazole and m2-9 treatment significantly decreased leucocyte response and increased the frequency of rearing, compared to infected mice treated with either drug alone. Therefore, m2-9 is a natural product with potentially significant therapeutic value for angiostrongyliasis and is worthy of further study. SN - 1475-2697 UR - https://www.unboundmedicine.com/medline/citation/22050968/Efficacy_of_albendazole_combined_with_a_marine_fungal_extract__m2_9__against_Angiostrongylus_cantonensis_induced_meningitis_in_mice_ L2 - https://www.cambridge.org/core/product/identifier/S0022149X11000630/type/journal_article DB - PRIME DP - Unbound Medicine ER -