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Human papillomavirus in oropharyngeal squamous cell carcinomas in Korea: use of G1 cycle markers as new prognosticators.
Head Neck 2012; 34(10):1408-17HN

Abstract

BACKGROUND

Human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (SCC) exhibits distinct patterns worldwide, but its prevalence has not been extensively evaluated in Korea. The E7 oncogene-mediated carcinogenesis and its meaning are yet to be uncovered for oropharyngeal SCCs.

METHODS

In a Korean oropharyngeal SCC cohort, epidemiological indicators, HPV, and G1 cell cycle marker expressions were correlated with survival.

RESULTS

Among 93 surgically treated patients with oropharyngeal SCCs, 49.5% were HPV+, which were significantly younger, and predominantly nonsmoking. They demonstrated better survival than HPV- (94% vs 60%). Patients who were HPV+ with oropharyngeal SCCs expressed higher p16, cyclin-dependent kinase 4 (cdk4), and lower pRb. The p16 (hazard ratio [HR] 2.39), pRb (HR 2.13), and CCND1 (HR 2.09) correlated with survival. Notably, combined markers like p16/cdk4 ratio (HR 2.47) and cdk4+CCND1 sum (HR 2.65) were more significantly correlated.

CONCLUSION

Incidence of HPV-related oropharyngeal SCC in Korea is similar to U.S.-European data. HPV presence correlates with improved survival. Expression ratios of G1 markers may predict survival of oropharyngeal SCCs better than each marker alone.

Authors+Show Affiliations

Department of Pathology and Division of Specific Organ Cancer, Research Institute and Hospital, National Cancer Center, Goyang-si, Gyeonggi-do, 410-769, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

22052559

Citation

Park, Weon Seo, et al. "Human Papillomavirus in Oropharyngeal Squamous Cell Carcinomas in Korea: Use of G1 Cycle Markers as New Prognosticators." Head & Neck, vol. 34, no. 10, 2012, pp. 1408-17.
Park WS, Ryu J, Cho KH, et al. Human papillomavirus in oropharyngeal squamous cell carcinomas in Korea: use of G1 cycle markers as new prognosticators. Head Neck. 2012;34(10):1408-17.
Park, W. S., Ryu, J., Cho, K. H., Choi, M. K., Moon, S. H., Yun, T., ... Jung, Y. S. (2012). Human papillomavirus in oropharyngeal squamous cell carcinomas in Korea: use of G1 cycle markers as new prognosticators. Head & Neck, 34(10), pp. 1408-17. doi:10.1002/hed.21939.
Park WS, et al. Human Papillomavirus in Oropharyngeal Squamous Cell Carcinomas in Korea: Use of G1 Cycle Markers as New Prognosticators. Head Neck. 2012;34(10):1408-17. PubMed PMID: 22052559.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Human papillomavirus in oropharyngeal squamous cell carcinomas in Korea: use of G1 cycle markers as new prognosticators. AU - Park,Weon Seo, AU - Ryu,Junsun, AU - Cho,Kwan Ho, AU - Choi,Moon Kyung, AU - Moon,Sung Ho, AU - Yun,Tak, AU - Chun,Byung-Sam, AU - Lee,Geon Kook, AU - Ahn,Hyun-Joo, AU - Lee,John H, AU - Vermeer,Paola, AU - Jung,Yuh-Seog, Y1 - 2011/11/02/ PY - 2011/08/03/accepted PY - 2011/11/5/entrez PY - 2011/11/5/pubmed PY - 2013/3/8/medline SP - 1408 EP - 17 JF - Head & neck JO - Head Neck VL - 34 IS - 10 N2 - BACKGROUND: Human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (SCC) exhibits distinct patterns worldwide, but its prevalence has not been extensively evaluated in Korea. The E7 oncogene-mediated carcinogenesis and its meaning are yet to be uncovered for oropharyngeal SCCs. METHODS: In a Korean oropharyngeal SCC cohort, epidemiological indicators, HPV, and G1 cell cycle marker expressions were correlated with survival. RESULTS: Among 93 surgically treated patients with oropharyngeal SCCs, 49.5% were HPV+, which were significantly younger, and predominantly nonsmoking. They demonstrated better survival than HPV- (94% vs 60%). Patients who were HPV+ with oropharyngeal SCCs expressed higher p16, cyclin-dependent kinase 4 (cdk4), and lower pRb. The p16 (hazard ratio [HR] 2.39), pRb (HR 2.13), and CCND1 (HR 2.09) correlated with survival. Notably, combined markers like p16/cdk4 ratio (HR 2.47) and cdk4+CCND1 sum (HR 2.65) were more significantly correlated. CONCLUSION: Incidence of HPV-related oropharyngeal SCC in Korea is similar to U.S.-European data. HPV presence correlates with improved survival. Expression ratios of G1 markers may predict survival of oropharyngeal SCCs better than each marker alone. SN - 1097-0347 UR - https://www.unboundmedicine.com/medline/citation/22052559/Human_papillomavirus_in_oropharyngeal_squamous_cell_carcinomas_in_Korea:_use_of_G1_cycle_markers_as_new_prognosticators_ L2 - https://doi.org/10.1002/hed.21939 DB - PRIME DP - Unbound Medicine ER -