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Curcumin alleviates eosinophilic meningitis through reduction of eosinophil count following albendazole treatment against Angiostrongylus cantonensis in mice.
Parasitology. 2012 Mar; 139(3):358-65.P

Abstract

Angiostrongylus cantonensis (A. cantonensis) is the most common cause of parasitic eosinophilic meningitis worldwide. By using an animal model of BALB/c mice infected with A. cantonensis, previous studies indicated that the anthelmintic drug, albendazole, could kill A. cantonensis larvae and prevent further infection. However, the dead larvae will induce severe immune responses targeting at brain tissues. To alleviate the detrimental effects caused by the dead larvae, we administered curcumin, a traditional anti-inflammatory agent, as a complementary treatment in addition to albendazole therapy, to determine whether curcumin could be beneficial for treatment. The results showed that although curcumin treatment alone did not reduce worm number, combined treatment by albendazole and curcumin helped to reduce eosinophil count in the cerebrospinal fluid, better than using albendazole alone. This alleviating effect did not affect albendazole treatment alone, since histological analysis showed similar worm eradication with or without addition of curcumin. Nevertheless, curcumin treatment alone and combined albendazole-curcumin treatment did not inhibit MMP-9 expression in the brain tissue. In conclusion, curcumin, when used as a complementary treatment to albendazole, could help to alleviate eosinophilic meningitis through suppression of eosinophil count in the cerebrospinal fluid.

Authors+Show Affiliations

Institute of Medicine, Chung Shan Medical University, Taiwan, ROC. sly@csmu.edu.twNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22053741

Citation

Shyu, Ling-Yuh, et al. "Curcumin Alleviates Eosinophilic Meningitis Through Reduction of Eosinophil Count Following Albendazole Treatment Against Angiostrongylus Cantonensis in Mice." Parasitology, vol. 139, no. 3, 2012, pp. 358-65.
Shyu LY, Chang HH, Hsu JD, et al. Curcumin alleviates eosinophilic meningitis through reduction of eosinophil count following albendazole treatment against Angiostrongylus cantonensis in mice. Parasitology. 2012;139(3):358-65.
Shyu, L. Y., Chang, H. H., Hsu, J. D., Lin, D. P., Teng, Y. H., & Lee, H. H. (2012). Curcumin alleviates eosinophilic meningitis through reduction of eosinophil count following albendazole treatment against Angiostrongylus cantonensis in mice. Parasitology, 139(3), 358-65. https://doi.org/10.1017/S0031182011001922
Shyu LY, et al. Curcumin Alleviates Eosinophilic Meningitis Through Reduction of Eosinophil Count Following Albendazole Treatment Against Angiostrongylus Cantonensis in Mice. Parasitology. 2012;139(3):358-65. PubMed PMID: 22053741.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Curcumin alleviates eosinophilic meningitis through reduction of eosinophil count following albendazole treatment against Angiostrongylus cantonensis in mice. AU - Shyu,Ling-Yuh, AU - Chang,Han-Hsin, AU - Hsu,Jeng-Dong, AU - Lin,David Pei-Cheng, AU - Teng,Ying-Hock, AU - Lee,Hsiu-Hsiung, Y1 - 2011/11/07/ PY - 2011/11/8/entrez PY - 2011/11/8/pubmed PY - 2013/5/3/medline SP - 358 EP - 65 JF - Parasitology JO - Parasitology VL - 139 IS - 3 N2 - Angiostrongylus cantonensis (A. cantonensis) is the most common cause of parasitic eosinophilic meningitis worldwide. By using an animal model of BALB/c mice infected with A. cantonensis, previous studies indicated that the anthelmintic drug, albendazole, could kill A. cantonensis larvae and prevent further infection. However, the dead larvae will induce severe immune responses targeting at brain tissues. To alleviate the detrimental effects caused by the dead larvae, we administered curcumin, a traditional anti-inflammatory agent, as a complementary treatment in addition to albendazole therapy, to determine whether curcumin could be beneficial for treatment. The results showed that although curcumin treatment alone did not reduce worm number, combined treatment by albendazole and curcumin helped to reduce eosinophil count in the cerebrospinal fluid, better than using albendazole alone. This alleviating effect did not affect albendazole treatment alone, since histological analysis showed similar worm eradication with or without addition of curcumin. Nevertheless, curcumin treatment alone and combined albendazole-curcumin treatment did not inhibit MMP-9 expression in the brain tissue. In conclusion, curcumin, when used as a complementary treatment to albendazole, could help to alleviate eosinophilic meningitis through suppression of eosinophil count in the cerebrospinal fluid. SN - 1469-8161 UR - https://www.unboundmedicine.com/medline/citation/22053741/Curcumin_alleviates_eosinophilic_meningitis_through_reduction_of_eosinophil_count_following_albendazole_treatment_against_Angiostrongylus_cantonensis_in_mice_ L2 - https://www.cambridge.org/core/product/identifier/S0031182011001922/type/journal_article DB - PRIME DP - Unbound Medicine ER -