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Survey of enterovirus infections from hand, foot and mouth disease outbreak in China, 2009.
Virol J. 2011 Nov 06; 8:508.VJ

Abstract

BACKGROUND

In China, a rapid expansion of Hand, foot, and mouth disease (HFMD) outbreaks has occurred since 2004 and HFMD has become an important issue for China. However, people are still only concerned with human enterovirus 71(HEV-71) and coxsackie virus A16 (CV-A16). Much of what is known about the other enterovirus infections relies on fractional evidence and old epidemic data, with little knowledge concerning their distribution. To alert potential threatens of the other enteroviruses, our study genetically characterized specimens from different regions of China and yielded novel information concerning the circulating and phylogenetic characteristics of enteroviral strains from HFMD cases.

FINDINGS

A total of 301 clinical throat swabs were randomly obtained from patients suffering from HFMD from the southern, northern and central regions of China during outbreaks in 2009. 266 of 301 (88.4%) HFMD cases were found positive for HEV and seven genotypes, HEV-71, CV-A16, -B5, -A4, -A6, -A10, and -A12, were detected.

CONCLUSIONS

The HFMD pathogen compositions in the different regions of China were significantly different. HFMD epidemics might persist for a long time in China due to the multiple pathogen compositions, the enteroviral characteristic of recombination and co-infection, the ever-increasing travel and migration and the deficiency of effective vaccine. Our study deserves the attention on HFMD control and vaccine development.

Authors+Show Affiliations

State Key Laboratory for Molecular Virology and Genetic Engineering, Institute of Pathogen Biology, Chinese Academy of Medical Sciences, Beijing, People's Republic of China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22054534

Citation

Yang, Fan, et al. "Survey of Enterovirus Infections From Hand, Foot and Mouth Disease Outbreak in China, 2009." Virology Journal, vol. 8, 2011, p. 508.
Yang F, Zhang T, Hu Y, et al. Survey of enterovirus infections from hand, foot and mouth disease outbreak in China, 2009. Virol J. 2011;8:508.
Yang, F., Zhang, T., Hu, Y., Wang, X., Du, J., Li, Y., Sun, S., Sun, X., Li, Z., & Jin, Q. (2011). Survey of enterovirus infections from hand, foot and mouth disease outbreak in China, 2009. Virology Journal, 8, 508. https://doi.org/10.1186/1743-422X-8-508
Yang F, et al. Survey of Enterovirus Infections From Hand, Foot and Mouth Disease Outbreak in China, 2009. Virol J. 2011 Nov 6;8:508. PubMed PMID: 22054534.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Survey of enterovirus infections from hand, foot and mouth disease outbreak in China, 2009. AU - Yang,Fan, AU - Zhang,Ting, AU - Hu,Yongfeng, AU - Wang,Xiaofang, AU - Du,Jiang, AU - Li,Yufen, AU - Sun,Shaoxia, AU - Sun,Xiuhua, AU - Li,Zhifang, AU - Jin,Qi, Y1 - 2011/11/06/ PY - 2011/05/11/received PY - 2011/11/06/accepted PY - 2011/11/8/entrez PY - 2011/11/8/pubmed PY - 2012/2/23/medline SP - 508 EP - 508 JF - Virology journal JO - Virol J VL - 8 N2 - BACKGROUND: In China, a rapid expansion of Hand, foot, and mouth disease (HFMD) outbreaks has occurred since 2004 and HFMD has become an important issue for China. However, people are still only concerned with human enterovirus 71(HEV-71) and coxsackie virus A16 (CV-A16). Much of what is known about the other enterovirus infections relies on fractional evidence and old epidemic data, with little knowledge concerning their distribution. To alert potential threatens of the other enteroviruses, our study genetically characterized specimens from different regions of China and yielded novel information concerning the circulating and phylogenetic characteristics of enteroviral strains from HFMD cases. FINDINGS: A total of 301 clinical throat swabs were randomly obtained from patients suffering from HFMD from the southern, northern and central regions of China during outbreaks in 2009. 266 of 301 (88.4%) HFMD cases were found positive for HEV and seven genotypes, HEV-71, CV-A16, -B5, -A4, -A6, -A10, and -A12, were detected. CONCLUSIONS: The HFMD pathogen compositions in the different regions of China were significantly different. HFMD epidemics might persist for a long time in China due to the multiple pathogen compositions, the enteroviral characteristic of recombination and co-infection, the ever-increasing travel and migration and the deficiency of effective vaccine. Our study deserves the attention on HFMD control and vaccine development. SN - 1743-422X UR - https://www.unboundmedicine.com/medline/citation/22054534/Survey_of_enterovirus_infections_from_hand_foot_and_mouth_disease_outbreak_in_China_2009_ L2 - https://virologyj.biomedcentral.com/articles/10.1186/1743-422X-8-508 DB - PRIME DP - Unbound Medicine ER -