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Ameliorative effect of diosmin, a citrus flavonoid against streptozotocin-nicotinamide generated oxidative stress induced diabetic rats.
Chem Biol Interact. 2012 Jan 05; 195(1):43-51.CB

Abstract

Oxidative stress has been suggested as a contributory factor in development and complication of diabetes. The aim of the study was to evaluate the effect of diosmin (DS) in oxidative stress in streptozotocin-nicotinamide (STZ-NA)-induced diabetic rats by measuring the lipid peroxidation (LPO) as well as the ameliorative properties. Experimental diabetes was induced by a single intraperitoneal (i.p) injection of STZ (45 mg/kg body weight (b.w.)) dissolved in 0.1 mol/L citrate buffer (pH 4.5), 15 min after the i.p administration of NA (110 mg/kg b.w.). Diabetic rats exhibited increased plasma glucose with significant decrease in plasma insulin levels. The activities of antioxidant enzymes superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione-S-transferase (GST) and the levels of low-molecular weight antioxidants vitamin C, vitamin E and reduced glutathione (GSH) were decreased while increases in the levels of LPO markers were observed in liver and kidney tissues of diabetic control rats as compared to normal control rats. Oral treatment with DS (100mg/kg/day) for a period of 45 days showed significant ameliorative effects on all the biochemical parameters studied. Biochemical findings were supported by histological studies. These results indicated that DS has potential ameliorative effects in addition to its antidiabetic effect in type 2 diabetic rats.

Authors+Show Affiliations

Department of Biochemistry and Biotechnology, Annamalai University, Tamilnadu, India.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22056647

Citation

Srinivasan, Subramani, and Leelavinothan Pari. "Ameliorative Effect of Diosmin, a Citrus Flavonoid Against Streptozotocin-nicotinamide Generated Oxidative Stress Induced Diabetic Rats." Chemico-biological Interactions, vol. 195, no. 1, 2012, pp. 43-51.
Srinivasan S, Pari L. Ameliorative effect of diosmin, a citrus flavonoid against streptozotocin-nicotinamide generated oxidative stress induced diabetic rats. Chem Biol Interact. 2012;195(1):43-51.
Srinivasan, S., & Pari, L. (2012). Ameliorative effect of diosmin, a citrus flavonoid against streptozotocin-nicotinamide generated oxidative stress induced diabetic rats. Chemico-biological Interactions, 195(1), 43-51. https://doi.org/10.1016/j.cbi.2011.10.003
Srinivasan S, Pari L. Ameliorative Effect of Diosmin, a Citrus Flavonoid Against Streptozotocin-nicotinamide Generated Oxidative Stress Induced Diabetic Rats. Chem Biol Interact. 2012 Jan 5;195(1):43-51. PubMed PMID: 22056647.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ameliorative effect of diosmin, a citrus flavonoid against streptozotocin-nicotinamide generated oxidative stress induced diabetic rats. AU - Srinivasan,Subramani, AU - Pari,Leelavinothan, Y1 - 2011/10/28/ PY - 2011/08/10/received PY - 2011/10/14/revised PY - 2011/10/18/accepted PY - 2011/11/8/entrez PY - 2011/11/8/pubmed PY - 2012/2/18/medline SP - 43 EP - 51 JF - Chemico-biological interactions JO - Chem Biol Interact VL - 195 IS - 1 N2 - Oxidative stress has been suggested as a contributory factor in development and complication of diabetes. The aim of the study was to evaluate the effect of diosmin (DS) in oxidative stress in streptozotocin-nicotinamide (STZ-NA)-induced diabetic rats by measuring the lipid peroxidation (LPO) as well as the ameliorative properties. Experimental diabetes was induced by a single intraperitoneal (i.p) injection of STZ (45 mg/kg body weight (b.w.)) dissolved in 0.1 mol/L citrate buffer (pH 4.5), 15 min after the i.p administration of NA (110 mg/kg b.w.). Diabetic rats exhibited increased plasma glucose with significant decrease in plasma insulin levels. The activities of antioxidant enzymes superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione-S-transferase (GST) and the levels of low-molecular weight antioxidants vitamin C, vitamin E and reduced glutathione (GSH) were decreased while increases in the levels of LPO markers were observed in liver and kidney tissues of diabetic control rats as compared to normal control rats. Oral treatment with DS (100mg/kg/day) for a period of 45 days showed significant ameliorative effects on all the biochemical parameters studied. Biochemical findings were supported by histological studies. These results indicated that DS has potential ameliorative effects in addition to its antidiabetic effect in type 2 diabetic rats. SN - 1872-7786 UR - https://www.unboundmedicine.com/medline/citation/22056647/Ameliorative_effect_of_diosmin_a_citrus_flavonoid_against_streptozotocin_nicotinamide_generated_oxidative_stress_induced_diabetic_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0009-2797(11)00307-3 DB - PRIME DP - Unbound Medicine ER -