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Peroxisome proliferator-activated receptor-α activation attenuates 3-nitropropionic acid induced behavioral and biochemical alterations in rats: possible neuroprotective mechanisms.
Eur J Pharmacol. 2012 Jan 05; 674(1):33-43.EJ

Abstract

Peroxisome proliferators activated receptor is regarded as potential therapeutic targets to control various neurodegenerative disorders. However, none of the study has elucidated its effect in the treatment of Huntington's disease. We explored whether peroxisome proliferators activated receptor-α agonist may attenuate various behavioral and biochemical alterations induced by systemic administration of 3-nitropropionic acid (3-NP), an accepted experimental animal model of Huntington's disease phenotype. Intraperitoneal administration of 3-NP (20mg/kg., i.p.) for 4days in rats produced hypolocomotion, muscle incoordination, and cognitive dysfunction. Daily treatment with fenofibrate (100 or 200mg/kg., p.o.), 30min prior to 3-NP administration for a total of 4days, significantly improved the 3-NP induced motor and cognitive impairment. Biochemical analysis revealed that systemic 3-NP administration significantly increased oxidative and nitrosative stress (increase lipid peroxidation, protein carbonyls and nitrite level), lactate dehydrogenase activity whereas, decreased the activities of catalase, superoxide dismutase, reduced glutathione, and succinate dehydrogenase. Fenofibrate treatment significantly attenuated oxidative damage, cytokines and improved mitochondrial complexes enzyme activity in brain. In the present study, MK886, a selective inhibitor of peroxisome proliferators activated receptor-α was employed to elucidate the beneficial effect through either receptor dependent or receptor independent neuroprotective mechanisms. Administration of MK886 (1mg/kg, i.p.) prior to fenofibrate (200mg/kg, p.o.) abolished the effect of fenofibrate. The results showed that receptor dependent neuroprotective effects of fenofibrate in 3-NP administered rats provide a new evidence for a role of PPAR-α activation in neuroprotection that is attributed by modulating oxidative stress and inflammation.

Authors+Show Affiliations

Neuropharmacology Division, Department of Pharmacology, ISF College of Pharmacy, Moga, Punjab, India. bhatejadeepak@gmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22056833

Citation

Bhateja, Deepak Kumar, et al. "Peroxisome Proliferator-activated Receptor-α Activation Attenuates 3-nitropropionic Acid Induced Behavioral and Biochemical Alterations in Rats: Possible Neuroprotective Mechanisms." European Journal of Pharmacology, vol. 674, no. 1, 2012, pp. 33-43.
Bhateja DK, Dhull DK, Gill A, et al. Peroxisome proliferator-activated receptor-α activation attenuates 3-nitropropionic acid induced behavioral and biochemical alterations in rats: possible neuroprotective mechanisms. Eur J Pharmacol. 2012;674(1):33-43.
Bhateja, D. K., Dhull, D. K., Gill, A., Sidhu, A., Sharma, S., Reddy, B. V., & Padi, S. S. (2012). Peroxisome proliferator-activated receptor-α activation attenuates 3-nitropropionic acid induced behavioral and biochemical alterations in rats: possible neuroprotective mechanisms. European Journal of Pharmacology, 674(1), 33-43. https://doi.org/10.1016/j.ejphar.2011.10.029
Bhateja DK, et al. Peroxisome Proliferator-activated Receptor-α Activation Attenuates 3-nitropropionic Acid Induced Behavioral and Biochemical Alterations in Rats: Possible Neuroprotective Mechanisms. Eur J Pharmacol. 2012 Jan 5;674(1):33-43. PubMed PMID: 22056833.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Peroxisome proliferator-activated receptor-α activation attenuates 3-nitropropionic acid induced behavioral and biochemical alterations in rats: possible neuroprotective mechanisms. AU - Bhateja,Deepak Kumar, AU - Dhull,Dinesh K, AU - Gill,Aneet, AU - Sidhu,Akramdeep, AU - Sharma,Saurabh, AU - Reddy,B V Krishna, AU - Padi,Satyanarayana S V, Y1 - 2011/10/26/ PY - 2011/04/07/received PY - 2011/10/07/revised PY - 2011/10/15/accepted PY - 2011/11/8/entrez PY - 2011/11/8/pubmed PY - 2012/3/27/medline SP - 33 EP - 43 JF - European journal of pharmacology JO - Eur J Pharmacol VL - 674 IS - 1 N2 - Peroxisome proliferators activated receptor is regarded as potential therapeutic targets to control various neurodegenerative disorders. However, none of the study has elucidated its effect in the treatment of Huntington's disease. We explored whether peroxisome proliferators activated receptor-α agonist may attenuate various behavioral and biochemical alterations induced by systemic administration of 3-nitropropionic acid (3-NP), an accepted experimental animal model of Huntington's disease phenotype. Intraperitoneal administration of 3-NP (20mg/kg., i.p.) for 4days in rats produced hypolocomotion, muscle incoordination, and cognitive dysfunction. Daily treatment with fenofibrate (100 or 200mg/kg., p.o.), 30min prior to 3-NP administration for a total of 4days, significantly improved the 3-NP induced motor and cognitive impairment. Biochemical analysis revealed that systemic 3-NP administration significantly increased oxidative and nitrosative stress (increase lipid peroxidation, protein carbonyls and nitrite level), lactate dehydrogenase activity whereas, decreased the activities of catalase, superoxide dismutase, reduced glutathione, and succinate dehydrogenase. Fenofibrate treatment significantly attenuated oxidative damage, cytokines and improved mitochondrial complexes enzyme activity in brain. In the present study, MK886, a selective inhibitor of peroxisome proliferators activated receptor-α was employed to elucidate the beneficial effect through either receptor dependent or receptor independent neuroprotective mechanisms. Administration of MK886 (1mg/kg, i.p.) prior to fenofibrate (200mg/kg, p.o.) abolished the effect of fenofibrate. The results showed that receptor dependent neuroprotective effects of fenofibrate in 3-NP administered rats provide a new evidence for a role of PPAR-α activation in neuroprotection that is attributed by modulating oxidative stress and inflammation. SN - 1879-0712 UR - https://www.unboundmedicine.com/medline/citation/22056833/Peroxisome_proliferator_activated_receptor_α_activation_attenuates_3_nitropropionic_acid_induced_behavioral_and_biochemical_alterations_in_rats:_possible_neuroprotective_mechanisms_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-2999(11)01397-5 DB - PRIME DP - Unbound Medicine ER -