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Ocular leprosy in nine-banded armadillos following intrastromal inoculation.
Int J Lepr Other Mycobact Dis. 1990 Sep; 58(3):554-9.IJ

Abstract

Leprosy shows a higher percentage of ocular involvement than any other systemic infection. In humans, the cornea is the first ocular tissue affected. Our previous studies in armadillos with naturally acquired and experimental disseminated leprosy showed that 44% had corneal infection. Mycobacterium leprae is found in armadillo burrows in Louisiana, U.S.A., and ocular abrasions may be the portal of entry for these organisms in wild armadillos. To test the cornea as a route of infection, we injected eight armadillos intrastromally with 2 x 10(6) M. leprae in 1 microliters. Two and 4 months later, the armadillos were sacrificed and their eyes processed for light- and electron-microscopy. After 2 months, M. leprae were found in histiocytes mainly in the corneal limbus, sclera and bulbar conjunctiva. At 4 months, however, there was a visible corneal leproma in one animal. Microscopically, it was found to be a histiocytic granuloma with heavy M. leprae invasion. In addition, cells were seen in the anterior chamber. Leprosy is endemic in regions where other corneal infections which compromise the epithelial barrier property are prevalent and where leprosy bacilli are found in the environment. The entry of leprosy bacilli into the cornea may produce lesions which spread posteriorly in the eye.

Authors+Show Affiliations

LSU Eye Center, Louisiana State University School of Medicine, New Orleans 70112.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

2205689

Citation

Malaty, R, et al. "Ocular Leprosy in Nine-banded Armadillos Following Intrastromal Inoculation." International Journal of Leprosy and Other Mycobacterial Diseases : Official Organ of the International Leprosy Association, vol. 58, no. 3, 1990, pp. 554-9.
Malaty R, Beuerman RW, Pedroza L. Ocular leprosy in nine-banded armadillos following intrastromal inoculation. Int J Lepr Other Mycobact Dis. 1990;58(3):554-9.
Malaty, R., Beuerman, R. W., & Pedroza, L. (1990). Ocular leprosy in nine-banded armadillos following intrastromal inoculation. International Journal of Leprosy and Other Mycobacterial Diseases : Official Organ of the International Leprosy Association, 58(3), 554-9.
Malaty R, Beuerman RW, Pedroza L. Ocular Leprosy in Nine-banded Armadillos Following Intrastromal Inoculation. Int J Lepr Other Mycobact Dis. 1990;58(3):554-9. PubMed PMID: 2205689.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ocular leprosy in nine-banded armadillos following intrastromal inoculation. AU - Malaty,R, AU - Beuerman,R W, AU - Pedroza,L, PY - 1990/9/1/pubmed PY - 1990/9/1/medline PY - 1990/9/1/entrez SP - 554 EP - 9 JF - International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association JO - Int J Lepr Other Mycobact Dis VL - 58 IS - 3 N2 - Leprosy shows a higher percentage of ocular involvement than any other systemic infection. In humans, the cornea is the first ocular tissue affected. Our previous studies in armadillos with naturally acquired and experimental disseminated leprosy showed that 44% had corneal infection. Mycobacterium leprae is found in armadillo burrows in Louisiana, U.S.A., and ocular abrasions may be the portal of entry for these organisms in wild armadillos. To test the cornea as a route of infection, we injected eight armadillos intrastromally with 2 x 10(6) M. leprae in 1 microliters. Two and 4 months later, the armadillos were sacrificed and their eyes processed for light- and electron-microscopy. After 2 months, M. leprae were found in histiocytes mainly in the corneal limbus, sclera and bulbar conjunctiva. At 4 months, however, there was a visible corneal leproma in one animal. Microscopically, it was found to be a histiocytic granuloma with heavy M. leprae invasion. In addition, cells were seen in the anterior chamber. Leprosy is endemic in regions where other corneal infections which compromise the epithelial barrier property are prevalent and where leprosy bacilli are found in the environment. The entry of leprosy bacilli into the cornea may produce lesions which spread posteriorly in the eye. SN - 0148-916X UR - https://www.unboundmedicine.com/medline/citation/2205689/Ocular_leprosy_in_nine_banded_armadillos_following_intrastromal_inoculation_ L2 - https://medlineplus.gov/mycobacterialinfections.html DB - PRIME DP - Unbound Medicine ER -