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Matriderm® 1 mm versus Integra® Single Layer 1.3 mm for one-step closure of full thickness skin defects: a comparative experimental study in rats.
Pediatr Surg Int. 2012 Feb; 28(2):171-7.PS

Abstract

PURPOSE

Dermal templates, such as Matriderm® and Integra®, are widely used in plastic and reconstructive surgery, often as two-step procedures. A recent development is the application of thin dermal templates covered with split thickness skin grafts in one-step procedures. In this experimental study, we compare the two thin matrices Matriderm® 1 mm and Integra® Single Layer in a one-step procedure with particular focus on neodermis formation.

METHODS

Matriderm® 1 mm and Integra® Dermal Regeneration Template-Single Layer (1.3 mm) were compared in a rat model. In three groups of five animals each, a full thickness wound was covered with (a) Matriderm® 1 mm and neonatal rat epidermis, (b) Integra® Single Layer and neonatal rat epidermis, or, (c) neonatal rat epidermis only (control). Histological sections 2 weeks post transplantation were analyzed with regard to take of template and epidermis, neodermal thickness, collagen deposition, vascularization, and inflammatory response.

RESULTS

Take of both templates was complete in all animals. The Matriderm®-based neodermis was thinner but showed a higher cell density than the Integra®-based neodermis. The other parameters were similar in both matrices.

CONCLUSION

The two templates demonstrate a comparable biological behavior early after transplantation. The only difference was found regarding neodermal thickness, probably resulting from faster degradation of Matriderm®. These preliminary data suggest that both dermal templates appear similarly suitable for transplantation in a one-step procedure.

Authors+Show Affiliations

Department of Surgery, Tissue Biology Research Unit, University Children's Hospital Zurich, Zurich, Switzerland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22057576

Citation

Böttcher-Haberzeth, Sophie, et al. "Matriderm® 1 Mm Versus Integra® Single Layer 1.3 Mm for One-step Closure of Full Thickness Skin Defects: a Comparative Experimental Study in Rats." Pediatric Surgery International, vol. 28, no. 2, 2012, pp. 171-7.
Böttcher-Haberzeth S, Biedermann T, Schiestl C, et al. Matriderm® 1 mm versus Integra® Single Layer 1.3 mm for one-step closure of full thickness skin defects: a comparative experimental study in rats. Pediatr Surg Int. 2012;28(2):171-7.
Böttcher-Haberzeth, S., Biedermann, T., Schiestl, C., Hartmann-Fritsch, F., Schneider, J., Reichmann, E., & Meuli, M. (2012). Matriderm® 1 mm versus Integra® Single Layer 1.3 mm for one-step closure of full thickness skin defects: a comparative experimental study in rats. Pediatric Surgery International, 28(2), 171-7. https://doi.org/10.1007/s00383-011-2990-5
Böttcher-Haberzeth S, et al. Matriderm® 1 Mm Versus Integra® Single Layer 1.3 Mm for One-step Closure of Full Thickness Skin Defects: a Comparative Experimental Study in Rats. Pediatr Surg Int. 2012;28(2):171-7. PubMed PMID: 22057576.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Matriderm® 1 mm versus Integra® Single Layer 1.3 mm for one-step closure of full thickness skin defects: a comparative experimental study in rats. AU - Böttcher-Haberzeth,Sophie, AU - Biedermann,Thomas, AU - Schiestl,Clemens, AU - Hartmann-Fritsch,Fabienne, AU - Schneider,Jörg, AU - Reichmann,Ernst, AU - Meuli,Martin, PY - 2011/11/8/entrez PY - 2011/11/8/pubmed PY - 2012/6/13/medline SP - 171 EP - 7 JF - Pediatric surgery international JO - Pediatr. Surg. Int. VL - 28 IS - 2 N2 - PURPOSE: Dermal templates, such as Matriderm® and Integra®, are widely used in plastic and reconstructive surgery, often as two-step procedures. A recent development is the application of thin dermal templates covered with split thickness skin grafts in one-step procedures. In this experimental study, we compare the two thin matrices Matriderm® 1 mm and Integra® Single Layer in a one-step procedure with particular focus on neodermis formation. METHODS: Matriderm® 1 mm and Integra® Dermal Regeneration Template-Single Layer (1.3 mm) were compared in a rat model. In three groups of five animals each, a full thickness wound was covered with (a) Matriderm® 1 mm and neonatal rat epidermis, (b) Integra® Single Layer and neonatal rat epidermis, or, (c) neonatal rat epidermis only (control). Histological sections 2 weeks post transplantation were analyzed with regard to take of template and epidermis, neodermal thickness, collagen deposition, vascularization, and inflammatory response. RESULTS: Take of both templates was complete in all animals. The Matriderm®-based neodermis was thinner but showed a higher cell density than the Integra®-based neodermis. The other parameters were similar in both matrices. CONCLUSION: The two templates demonstrate a comparable biological behavior early after transplantation. The only difference was found regarding neodermal thickness, probably resulting from faster degradation of Matriderm®. These preliminary data suggest that both dermal templates appear similarly suitable for transplantation in a one-step procedure. SN - 1437-9813 UR - https://www.unboundmedicine.com/medline/citation/22057576/Matriderm®_1_mm_versus_Integra®_Single_Layer_1_3_mm_for_one_step_closure_of_full_thickness_skin_defects:_a_comparative_experimental_study_in_rats_ L2 - https://dx.doi.org/10.1007/s00383-011-2990-5 DB - PRIME DP - Unbound Medicine ER -