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Interpenetrating polymer network (IPN) hydrogel microspheres for oral controlled release application.
Int J Biol Macromol. 2012 Jan 01; 50(1):198-206.IJ

Abstract

Interpenetrating polymer network (IPN) hydrogel microspheres of sodium carboxymethyl cellulose (NaCMC) and poly(vinyl alcohol) (PVA) were prepared by water-in-oil (w/o) emulsion crosslinking method for oral controlled release delivery of a non-steroidal anti-inflammatory drug, diclofenac sodium (DS). The microspheres were prepared with various ratios of NaCMC to PVA, % drug loading and extent of crosslinking density at a fixed polymer weight. The prepared microspheres with loose and rigid surfaces were evidenced by scanning electron microscope (SEM). Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD) analysis confirmed the IPN formation. Differential scanning calorimetry (DSC) study was performed to understand the dispersion nature of drug after encapsulation. The in vitro drug release study was extensively evaluated depending on the process variables in both acid and alkaline media. All the formulations exhibited satisfactory physicochemical and in vitro release characteristics. Release data indicated a non-Fickian trend of drug release from the formulations. Based on the results of this study suggest that DS loaded IPN microspheres were suitable for oral controlled release application.

Authors+Show Affiliations

School of Pharmaceutical Sciences, IFTM University, Moradabad, Uttar Pradesh, India. banerjee.subham@yahoo.co.inNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22062120

Citation

Banerjee, Subham, et al. "Interpenetrating Polymer Network (IPN) Hydrogel Microspheres for Oral Controlled Release Application." International Journal of Biological Macromolecules, vol. 50, no. 1, 2012, pp. 198-206.
Banerjee S, Siddiqui L, Bhattacharya SS, et al. Interpenetrating polymer network (IPN) hydrogel microspheres for oral controlled release application. Int J Biol Macromol. 2012;50(1):198-206.
Banerjee, S., Siddiqui, L., Bhattacharya, S. S., Kaity, S., Ghosh, A., Chattopadhyay, P., Pandey, A., & Singh, L. (2012). Interpenetrating polymer network (IPN) hydrogel microspheres for oral controlled release application. International Journal of Biological Macromolecules, 50(1), 198-206. https://doi.org/10.1016/j.ijbiomac.2011.10.020
Banerjee S, et al. Interpenetrating Polymer Network (IPN) Hydrogel Microspheres for Oral Controlled Release Application. Int J Biol Macromol. 2012 Jan 1;50(1):198-206. PubMed PMID: 22062120.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Interpenetrating polymer network (IPN) hydrogel microspheres for oral controlled release application. AU - Banerjee,Subham, AU - Siddiqui,Lubna, AU - Bhattacharya,Shiv Sankar, AU - Kaity,Santanu, AU - Ghosh,Animesh, AU - Chattopadhyay,Pronobesh, AU - Pandey,Anurag, AU - Singh,Lokendra, Y1 - 2011/10/28/ PY - 2011/09/02/received PY - 2011/10/07/revised PY - 2011/10/22/accepted PY - 2011/11/9/entrez PY - 2011/11/9/pubmed PY - 2012/5/5/medline SP - 198 EP - 206 JF - International journal of biological macromolecules JO - Int J Biol Macromol VL - 50 IS - 1 N2 - Interpenetrating polymer network (IPN) hydrogel microspheres of sodium carboxymethyl cellulose (NaCMC) and poly(vinyl alcohol) (PVA) were prepared by water-in-oil (w/o) emulsion crosslinking method for oral controlled release delivery of a non-steroidal anti-inflammatory drug, diclofenac sodium (DS). The microspheres were prepared with various ratios of NaCMC to PVA, % drug loading and extent of crosslinking density at a fixed polymer weight. The prepared microspheres with loose and rigid surfaces were evidenced by scanning electron microscope (SEM). Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD) analysis confirmed the IPN formation. Differential scanning calorimetry (DSC) study was performed to understand the dispersion nature of drug after encapsulation. The in vitro drug release study was extensively evaluated depending on the process variables in both acid and alkaline media. All the formulations exhibited satisfactory physicochemical and in vitro release characteristics. Release data indicated a non-Fickian trend of drug release from the formulations. Based on the results of this study suggest that DS loaded IPN microspheres were suitable for oral controlled release application. SN - 1879-0003 UR - https://www.unboundmedicine.com/medline/citation/22062120/Interpenetrating_polymer_network__IPN__hydrogel_microspheres_for_oral_controlled_release_application_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0141-8130(11)00410-7 DB - PRIME DP - Unbound Medicine ER -