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Fcγ receptor IIB (FcγRIIB) maintains humoral tolerance in the human immune system in vivo.
Proc Natl Acad Sci U S A. 2011 Nov 15; 108(46):18772-7.PN

Abstract

Maintenance of immunological tolerance is crucial to prevent development of autoimmune disease. The production of autoantibodies is a hallmark of many autoimmune diseases and studies in mouse model systems suggest that inhibitory signaling molecules may be important checkpoints of humoral tolerance. By generating humanized mice with normal and functionally impaired Fcγ receptor IIB (FcγRIIB) variants, we show that the inhibitory Fcγ-receptor is a checkpoint of humoral tolerance in the human immune system in vivo. Impaired human FcγRIIB function resulted in the generation of higher levels of serum immunoglobulins, the production of different autoantibody specificities, and a higher proportion of human plasmablasts and plasma cells in vivo. Our results suggest that the inhibitory FcγRIIB may be an important checkpoint of humoral tolerance in the human immune system.

Authors+Show Affiliations

Department of Biology, Institute of Genetics, University of Erlangen-Nürnberg, 91058 Erlangen, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22065769

Citation

Baerenwaldt, Anne, et al. "Fcγ Receptor IIB (FcγRIIB) Maintains Humoral Tolerance in the Human Immune System in Vivo." Proceedings of the National Academy of Sciences of the United States of America, vol. 108, no. 46, 2011, pp. 18772-7.
Baerenwaldt A, Lux A, Danzer H, et al. Fcγ receptor IIB (FcγRIIB) maintains humoral tolerance in the human immune system in vivo. Proc Natl Acad Sci USA. 2011;108(46):18772-7.
Baerenwaldt, A., Lux, A., Danzer, H., Spriewald, B. M., Ullrich, E., Heidkamp, G., Dudziak, D., & Nimmerjahn, F. (2011). Fcγ receptor IIB (FcγRIIB) maintains humoral tolerance in the human immune system in vivo. Proceedings of the National Academy of Sciences of the United States of America, 108(46), 18772-7. https://doi.org/10.1073/pnas.1111810108
Baerenwaldt A, et al. Fcγ Receptor IIB (FcγRIIB) Maintains Humoral Tolerance in the Human Immune System in Vivo. Proc Natl Acad Sci USA. 2011 Nov 15;108(46):18772-7. PubMed PMID: 22065769.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fcγ receptor IIB (FcγRIIB) maintains humoral tolerance in the human immune system in vivo. AU - Baerenwaldt,Anne, AU - Lux,Anja, AU - Danzer,Heike, AU - Spriewald,Bernd M, AU - Ullrich,Evelyn, AU - Heidkamp,Gordon, AU - Dudziak,Diana, AU - Nimmerjahn,Falk, Y1 - 2011/11/07/ PY - 2011/11/9/entrez PY - 2011/11/9/pubmed PY - 2012/1/27/medline SP - 18772 EP - 7 JF - Proceedings of the National Academy of Sciences of the United States of America JO - Proc. Natl. Acad. Sci. U.S.A. VL - 108 IS - 46 N2 - Maintenance of immunological tolerance is crucial to prevent development of autoimmune disease. The production of autoantibodies is a hallmark of many autoimmune diseases and studies in mouse model systems suggest that inhibitory signaling molecules may be important checkpoints of humoral tolerance. By generating humanized mice with normal and functionally impaired Fcγ receptor IIB (FcγRIIB) variants, we show that the inhibitory Fcγ-receptor is a checkpoint of humoral tolerance in the human immune system in vivo. Impaired human FcγRIIB function resulted in the generation of higher levels of serum immunoglobulins, the production of different autoantibody specificities, and a higher proportion of human plasmablasts and plasma cells in vivo. Our results suggest that the inhibitory FcγRIIB may be an important checkpoint of humoral tolerance in the human immune system. SN - 1091-6490 UR - https://www.unboundmedicine.com/medline/citation/22065769/Fcγ_receptor_IIB__FcγRIIB__maintains_humoral_tolerance_in_the_human_immune_system_in_vivo_ L2 - http://www.pnas.org/cgi/pmidlookup?view=long&pmid=22065769 DB - PRIME DP - Unbound Medicine ER -