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Proanthocyanidin-rich extracts from cranberry fruit (Vaccinium macrocarpon Ait.) selectively inhibit the growth of human pathogenic fungi Candida spp. and Cryptococcus neoformans.
J Agric Food Chem 2011; 59(24):12864-73JA

Abstract

Cranberry (Vaccinium macrocarpon) has been shown in clinical studies to reduce infections caused by Escherichia coli and other bacteria, and proanthocyanidins are believed to play a role. The ability of cranberry to inhibit the growth of opportunistic human fungal pathogens that cause oral, skin, respiratory, and systemic infections has not been well-studied. Fractions from whole cranberry fruit were screened for inhibition of five Candida species and Cryptococcus neoformans , a causative agent of fungal meningitis. Candida glabrata , Candida lusitaniae , Candida krusei , and Cryptococcus neoformans showed significant susceptibility to treatment with cranberry proanthocyanidin fractions in a broth microdilution assay, with minimum inhibitory concentrations as low as 1 μg/mL. MALDI-TOF MS analysis of subfractions detected epicatechin oligomers of up to 12 degrees of polymerization. Those containing larger oligomers caused the strongest inhibition. This study suggests that cranberry has potential as an antifungal agent.

Authors+Show Affiliations

Department of Chemistry and Biochemistry, University of Massachusetts-Dartmouth, 285 Old Westport Road, North Dartmouth, Massachusetts 02747, United States.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22066866

Citation

Patel, Kunal D., et al. "Proanthocyanidin-rich Extracts From Cranberry Fruit (Vaccinium Macrocarpon Ait.) Selectively Inhibit the Growth of Human Pathogenic Fungi Candida Spp. and Cryptococcus Neoformans." Journal of Agricultural and Food Chemistry, vol. 59, no. 24, 2011, pp. 12864-73.
Patel KD, Scarano FJ, Kondo M, et al. Proanthocyanidin-rich extracts from cranberry fruit (Vaccinium macrocarpon Ait.) selectively inhibit the growth of human pathogenic fungi Candida spp. and Cryptococcus neoformans. J Agric Food Chem. 2011;59(24):12864-73.
Patel, K. D., Scarano, F. J., Kondo, M., Hurta, R. A., & Neto, C. C. (2011). Proanthocyanidin-rich extracts from cranberry fruit (Vaccinium macrocarpon Ait.) selectively inhibit the growth of human pathogenic fungi Candida spp. and Cryptococcus neoformans. Journal of Agricultural and Food Chemistry, 59(24), pp. 12864-73. doi:10.1021/jf2035466.
Patel KD, et al. Proanthocyanidin-rich Extracts From Cranberry Fruit (Vaccinium Macrocarpon Ait.) Selectively Inhibit the Growth of Human Pathogenic Fungi Candida Spp. and Cryptococcus Neoformans. J Agric Food Chem. 2011 Dec 28;59(24):12864-73. PubMed PMID: 22066866.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Proanthocyanidin-rich extracts from cranberry fruit (Vaccinium macrocarpon Ait.) selectively inhibit the growth of human pathogenic fungi Candida spp. and Cryptococcus neoformans. AU - Patel,Kunal D, AU - Scarano,Frank J, AU - Kondo,Miwako, AU - Hurta,Robert A R, AU - Neto,Catherine C, Y1 - 2011/11/18/ PY - 2011/11/10/entrez PY - 2011/11/10/pubmed PY - 2012/5/4/medline SP - 12864 EP - 73 JF - Journal of agricultural and food chemistry JO - J. Agric. Food Chem. VL - 59 IS - 24 N2 - Cranberry (Vaccinium macrocarpon) has been shown in clinical studies to reduce infections caused by Escherichia coli and other bacteria, and proanthocyanidins are believed to play a role. The ability of cranberry to inhibit the growth of opportunistic human fungal pathogens that cause oral, skin, respiratory, and systemic infections has not been well-studied. Fractions from whole cranberry fruit were screened for inhibition of five Candida species and Cryptococcus neoformans , a causative agent of fungal meningitis. Candida glabrata , Candida lusitaniae , Candida krusei , and Cryptococcus neoformans showed significant susceptibility to treatment with cranberry proanthocyanidin fractions in a broth microdilution assay, with minimum inhibitory concentrations as low as 1 μg/mL. MALDI-TOF MS analysis of subfractions detected epicatechin oligomers of up to 12 degrees of polymerization. Those containing larger oligomers caused the strongest inhibition. This study suggests that cranberry has potential as an antifungal agent. SN - 1520-5118 UR - https://www.unboundmedicine.com/medline/citation/22066866/Proanthocyanidin_rich_extracts_from_cranberry_fruit__Vaccinium_macrocarpon_Ait___selectively_inhibit_the_growth_of_human_pathogenic_fungi_Candida_spp__and_Cryptococcus_neoformans_ L2 - https://dx.doi.org/10.1021/jf2035466 DB - PRIME DP - Unbound Medicine ER -