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Maternal intake of fatty acids during pregnancy and allergies in the offspring.
Br J Nutr. 2012 Aug; 108(4):720-32.BJ

Abstract

Fatty acids (FA) are known to have a number of immunological effects and, accordingly, may play a role in the development of allergic diseases. We investigated the effect of maternal intake of FA during pregnancy on the risk of allergic rhinitis, wheeze and atopic eczema in children aged 5 years. The present study analysed data from the Finnish Type 1 Diabetes Prediction and Prevention Nutrition Study, a population-based birth cohort study with a 5-year follow-up. Complete information on maternal diet (assessed by a validated FFQ) and International Study of Asthma and Allergies in Childhood-based allergic outcomes was available for 2441 children. Cox proportional regression and logistic regression were used for the analyses. After adjusting for potential confounding variables, high maternal consumption of butter and butter spreads (hazard ratio (HR) 1.33; 95 % CI 1.03, 1.71) and higher ratio of n-6:n-3 FA (HR 1.37; 95 % CI 1.07, 1.77) during pregnancy were associated with an increased risk of allergic rhinitis in the offspring by 5 years of age. High maternal intakes of total PUFA (HR 0.71; 95 % CI 0.52, 0.96) and α-linolenic FA (HR 0.73; 95 % CI 0.54, 0.98) were associated with a decreased risk of allergic rhinitis. However, these results lost their significance after adjustment for multiple comparisons. Overall, our data suggest that maternal consumption of butter, the ratio of n-6:n-3 FA and intake of PUFA and α-linolenic FA during pregnancy may be potential determinants of allergic rhinitis in the offspring.

Authors+Show Affiliations

School of Health Sciences, University of Tampere, Tampere, Finland. bright.nwaru@uta.fiNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22067943

Citation

Nwaru, Bright I., et al. "Maternal Intake of Fatty Acids During Pregnancy and Allergies in the Offspring." The British Journal of Nutrition, vol. 108, no. 4, 2012, pp. 720-32.
Nwaru BI, Erkkola M, Lumia M, et al. Maternal intake of fatty acids during pregnancy and allergies in the offspring. Br J Nutr. 2012;108(4):720-32.
Nwaru, B. I., Erkkola, M., Lumia, M., Kronberg-Kippilä, C., Ahonen, S., Kaila, M., Ilonen, J., Simell, O., Knip, M., Veijola, R., & Virtanen, S. M. (2012). Maternal intake of fatty acids during pregnancy and allergies in the offspring. The British Journal of Nutrition, 108(4), 720-32. https://doi.org/10.1017/S0007114511005940
Nwaru BI, et al. Maternal Intake of Fatty Acids During Pregnancy and Allergies in the Offspring. Br J Nutr. 2012;108(4):720-32. PubMed PMID: 22067943.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Maternal intake of fatty acids during pregnancy and allergies in the offspring. AU - Nwaru,Bright I, AU - Erkkola,Maijaliisa, AU - Lumia,Mirka, AU - Kronberg-Kippilä,Carina, AU - Ahonen,Suvi, AU - Kaila,Minna, AU - Ilonen,Jorma, AU - Simell,Olli, AU - Knip,Mikael, AU - Veijola,Riitta, AU - Virtanen,Suvi M, Y1 - 2011/11/09/ PY - 2011/11/10/entrez PY - 2011/11/10/pubmed PY - 2012/10/23/medline SP - 720 EP - 32 JF - The British journal of nutrition JO - Br. J. Nutr. VL - 108 IS - 4 N2 - Fatty acids (FA) are known to have a number of immunological effects and, accordingly, may play a role in the development of allergic diseases. We investigated the effect of maternal intake of FA during pregnancy on the risk of allergic rhinitis, wheeze and atopic eczema in children aged 5 years. The present study analysed data from the Finnish Type 1 Diabetes Prediction and Prevention Nutrition Study, a population-based birth cohort study with a 5-year follow-up. Complete information on maternal diet (assessed by a validated FFQ) and International Study of Asthma and Allergies in Childhood-based allergic outcomes was available for 2441 children. Cox proportional regression and logistic regression were used for the analyses. After adjusting for potential confounding variables, high maternal consumption of butter and butter spreads (hazard ratio (HR) 1.33; 95 % CI 1.03, 1.71) and higher ratio of n-6:n-3 FA (HR 1.37; 95 % CI 1.07, 1.77) during pregnancy were associated with an increased risk of allergic rhinitis in the offspring by 5 years of age. High maternal intakes of total PUFA (HR 0.71; 95 % CI 0.52, 0.96) and α-linolenic FA (HR 0.73; 95 % CI 0.54, 0.98) were associated with a decreased risk of allergic rhinitis. However, these results lost their significance after adjustment for multiple comparisons. Overall, our data suggest that maternal consumption of butter, the ratio of n-6:n-3 FA and intake of PUFA and α-linolenic FA during pregnancy may be potential determinants of allergic rhinitis in the offspring. SN - 1475-2662 UR - https://www.unboundmedicine.com/medline/citation/22067943/Maternal_intake_of_fatty_acids_during_pregnancy_and_allergies_in_the_offspring_ L2 - https://www.cambridge.org/core/product/identifier/S0007114511005940/type/journal_article DB - PRIME DP - Unbound Medicine ER -