Tags

Type your tag names separated by a space and hit enter

Polyphenolic extract of lotus root (edible rhizome of Nelumbo nucifera) alleviates hepatic steatosis in obese diabetic db/db mice.
Lipids Health Dis 2011; 10:202LH

Abstract

BACKGROUND

Nonalcoholic fatty liver disease (NAFLD) is emerging as the most common liver disease of industrialized countries. Thus, discovering food components that can ameliorate NAFLD is of interest. Lotus root, the edible rhizome of Nelumbo nucifera, contains high levels of polyphenolic compounds, and several health-promoting properties of lotus root have been reported. In this study, we tested whether feeding a polyphenolic extract of lotus root to db/db mice protects them from hepatic steatosis.

RESULTS

After 3 weeks of feeding, the hepatomegaly and hepatic triglyceride accumulation were markedly alleviated in the lotus polyphenol-diet-fed db/db mice relative to the control mice. Although the lipolytic enzyme activity was not changed, the activities of lipogenic enzymes, such as fatty acid synthase and malic enzyme, were significantly lower in the lotus polyphenol diet-fed db/db mice. Additionally, the ESI-IT/MS and MALDI-TOF MS spectra revealed the presence of B-type proanthocyanidin polymers with polymerization degree up to 9 in the polyphenolic lotus root extract.

CONCLUSION

We speculate that the condensed tannins contained in lotus root can alleviate hepatic steatosis by suppressing the lipogenic enzyme activity in the livers of db/db mice.

Authors+Show Affiliations

Department of Applied Biochemistry and Food Science, Saga University, Saga 840-8502, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22067945

Citation

Tsuruta, Yumi, et al. "Polyphenolic Extract of Lotus Root (edible Rhizome of Nelumbo Nucifera) Alleviates Hepatic Steatosis in Obese Diabetic Db/db Mice." Lipids in Health and Disease, vol. 10, 2011, p. 202.
Tsuruta Y, Nagao K, Kai S, et al. Polyphenolic extract of lotus root (edible rhizome of Nelumbo nucifera) alleviates hepatic steatosis in obese diabetic db/db mice. Lipids Health Dis. 2011;10:202.
Tsuruta, Y., Nagao, K., Kai, S., Tsuge, K., Yoshimura, T., Koganemaru, K., & Yanagita, T. (2011). Polyphenolic extract of lotus root (edible rhizome of Nelumbo nucifera) alleviates hepatic steatosis in obese diabetic db/db mice. Lipids in Health and Disease, 10, p. 202. doi:10.1186/1476-511X-10-202.
Tsuruta Y, et al. Polyphenolic Extract of Lotus Root (edible Rhizome of Nelumbo Nucifera) Alleviates Hepatic Steatosis in Obese Diabetic Db/db Mice. Lipids Health Dis. 2011 Nov 9;10:202. PubMed PMID: 22067945.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Polyphenolic extract of lotus root (edible rhizome of Nelumbo nucifera) alleviates hepatic steatosis in obese diabetic db/db mice. AU - Tsuruta,Yumi, AU - Nagao,Koji, AU - Kai,Shunichi, AU - Tsuge,Keisuke, AU - Yoshimura,Takashi, AU - Koganemaru,Kazuyoshi, AU - Yanagita,Teruyoshi, Y1 - 2011/11/09/ PY - 2011/10/23/received PY - 2011/11/09/accepted PY - 2011/11/10/entrez PY - 2011/11/10/pubmed PY - 2012/3/20/medline SP - 202 EP - 202 JF - Lipids in health and disease JO - Lipids Health Dis VL - 10 N2 - BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) is emerging as the most common liver disease of industrialized countries. Thus, discovering food components that can ameliorate NAFLD is of interest. Lotus root, the edible rhizome of Nelumbo nucifera, contains high levels of polyphenolic compounds, and several health-promoting properties of lotus root have been reported. In this study, we tested whether feeding a polyphenolic extract of lotus root to db/db mice protects them from hepatic steatosis. RESULTS: After 3 weeks of feeding, the hepatomegaly and hepatic triglyceride accumulation were markedly alleviated in the lotus polyphenol-diet-fed db/db mice relative to the control mice. Although the lipolytic enzyme activity was not changed, the activities of lipogenic enzymes, such as fatty acid synthase and malic enzyme, were significantly lower in the lotus polyphenol diet-fed db/db mice. Additionally, the ESI-IT/MS and MALDI-TOF MS spectra revealed the presence of B-type proanthocyanidin polymers with polymerization degree up to 9 in the polyphenolic lotus root extract. CONCLUSION: We speculate that the condensed tannins contained in lotus root can alleviate hepatic steatosis by suppressing the lipogenic enzyme activity in the livers of db/db mice. SN - 1476-511X UR - https://www.unboundmedicine.com/medline/citation/22067945/Polyphenolic_extract_of_lotus_root__edible_rhizome_of_Nelumbo_nucifera__alleviates_hepatic_steatosis_in_obese_diabetic_db/db_mice_ L2 - https://lipidworld.biomedcentral.com/articles/10.1186/1476-511X-10-202 DB - PRIME DP - Unbound Medicine ER -