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Terminalia gum as a directly compressible excipient for controlled drug delivery.
AAPS PharmSciTech. 2012 Mar; 13(1):16-23.AP

Abstract

The exudates from the incised trunk of Terminalia randii has been evaluated as controlled release excipient in comparison with xanthan gum and hydroxypropylmethylcellulose (HPMC) using carvedilol (water insoluble) and theophylline (water soluble) as model drugs. Matrix tablets were prepared by direct compression and the effects of polymer concentration and excipients-spray dried lactose, microcrystalline cellulose and dicalcium phosphate dihydrate on the mechanical (crushing strength (CS) friability (F) and crushing strength-friability ratio (CSFR)) and drug release properties of the matrix tablets were evaluated. The drug release data were fitted into different release kinetics equations to determine the drug release mechanism(s) from the matrix tablets. The results showed that the CS and CSFR increased with increase in polymer concentration while F decreased. The ranking of CS and CSFR was HPMC > terminalia > xanthan while the ranking was reverse for F. The ranking for t(25) (i.e. time for 25% drug release) at a polymer concentration of 60% was xanthan > terminalia = HPMC. The dissolution time, t(25), of theophylline matrices was significantly lower (p < 0.001) than those of carvedilol matrix tablets. Drug release from the matrices was by swelling, diffusion and erosion. The mechanical and drug release properties of the tablets were significantly (p < 0.05) dependent on the type and concentration of polymer and excipients used with the release mechanisms varying from Fickian to anomalous. Terminalia gum compared favourably with standard polymers when used in controlled release matrices and could serve as a suitable alternative to the standard polymers in drug delivery.

Authors+Show Affiliations

Department of Pharmaceutics and Pharmaceutical Technology, Olabisi Onabanjo University, Sagamu, Nigeria.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22068290

Citation

Bamiro, Oluyemisi A., et al. "Terminalia Gum as a Directly Compressible Excipient for Controlled Drug Delivery." AAPS PharmSciTech, vol. 13, no. 1, 2012, pp. 16-23.
Bamiro OA, Odeku OA, Sinha VR, et al. Terminalia gum as a directly compressible excipient for controlled drug delivery. AAPS PharmSciTech. 2012;13(1):16-23.
Bamiro, O. A., Odeku, O. A., Sinha, V. R., & Kumar, R. (2012). Terminalia gum as a directly compressible excipient for controlled drug delivery. AAPS PharmSciTech, 13(1), 16-23. https://doi.org/10.1208/s12249-011-9712-0
Bamiro OA, et al. Terminalia Gum as a Directly Compressible Excipient for Controlled Drug Delivery. AAPS PharmSciTech. 2012;13(1):16-23. PubMed PMID: 22068290.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Terminalia gum as a directly compressible excipient for controlled drug delivery. AU - Bamiro,Oluyemisi A, AU - Odeku,Oluwatoyin A, AU - Sinha,Vivek R, AU - Kumar,Ruchita, Y1 - 2011/11/09/ PY - 2011/06/22/received PY - 2011/10/06/accepted PY - 2011/11/10/entrez PY - 2011/11/10/pubmed PY - 2012/10/31/medline SP - 16 EP - 23 JF - AAPS PharmSciTech JO - AAPS PharmSciTech VL - 13 IS - 1 N2 - The exudates from the incised trunk of Terminalia randii has been evaluated as controlled release excipient in comparison with xanthan gum and hydroxypropylmethylcellulose (HPMC) using carvedilol (water insoluble) and theophylline (water soluble) as model drugs. Matrix tablets were prepared by direct compression and the effects of polymer concentration and excipients-spray dried lactose, microcrystalline cellulose and dicalcium phosphate dihydrate on the mechanical (crushing strength (CS) friability (F) and crushing strength-friability ratio (CSFR)) and drug release properties of the matrix tablets were evaluated. The drug release data were fitted into different release kinetics equations to determine the drug release mechanism(s) from the matrix tablets. The results showed that the CS and CSFR increased with increase in polymer concentration while F decreased. The ranking of CS and CSFR was HPMC > terminalia > xanthan while the ranking was reverse for F. The ranking for t(25) (i.e. time for 25% drug release) at a polymer concentration of 60% was xanthan > terminalia = HPMC. The dissolution time, t(25), of theophylline matrices was significantly lower (p < 0.001) than those of carvedilol matrix tablets. Drug release from the matrices was by swelling, diffusion and erosion. The mechanical and drug release properties of the tablets were significantly (p < 0.05) dependent on the type and concentration of polymer and excipients used with the release mechanisms varying from Fickian to anomalous. Terminalia gum compared favourably with standard polymers when used in controlled release matrices and could serve as a suitable alternative to the standard polymers in drug delivery. SN - 1530-9932 UR - https://www.unboundmedicine.com/medline/citation/22068290/Terminalia_gum_as_a_directly_compressible_excipient_for_controlled_drug_delivery_ L2 - https://dx.doi.org/10.1208/s12249-011-9712-0 DB - PRIME DP - Unbound Medicine ER -