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Serum levels of TNF-α, IL-1β, COMP, and CTX-II in patients with Kashin-Beck disease in Sichuan, China.
Rheumatol Int. 2012 Nov; 32(11):3503-9.RI

Abstract

The aim of the study was to detect differences in serum levels of interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), cartilage oligomeric matrix protein (COMP), type II collagen (CTX-II) between patients with Kashin-Beck disease (KBD) or osteoarthritis (OA) and to assess the correlation between these differences with the clinical grade of KBD. A total of one hundred fifty adult serum samples were collected; these samples belonged to the KBD group (n = 64), the OA group in KBD-prevalent areas (n = 47) and a healthy control group in non-KBD area (n = 39). Serum levels of TNF-α, IL-1β, COMP, and CTX-II were determined by a sandwich enzyme-linked immunosorbent assay, and the results were compared among the 3 groups (KBD/OA/normal) and between the different grades of KBD as well. The serum levels of IL-1β, TNF-α, COMP, and CTX-II were significantly higher in the KBD and OA group than the healthy adult group (P < 0.001), and TNF-α and IL-1β levels in the KBD group were similar to the OA group (for TNF-α, 14.38 ± 7.42 pg/ml vs. 12.61 ± 4.00 pg/ml, respectively, [P = 0.29]; for IL-1β, 141.53 ± 71.35 pg/ml vs. 135.61 ± 68.60 pg/ml, respectively, [P = 0.63]). However, the COMP level was significantly lower and the CTX-II level was higher in the KBD group than in the OA group (for COMP, 7.03 ± 3.11 ng/ml vs. 9.20 ± 3.51 ng/ml, respectively, [P = 0.003]; for CTX-II, 2.23 ± 0.79 ng/ml vs. 1.80 ± 0.87 ng/ml, respectively, [P = 0.026]). Moreover, no significant correlations were found between clinical grade and serum levels of TNF-α, IL-1β, COMP, and CTX-II for the 3 grades of KBD patients (P = 0.645, 0.481, 0.832, and 0.270, respectively). This study showed that serum levels of COMP in KBD patients decreased and CTX-II levels increased compared with the levels in OA patients, but TNF-α and IL-1β levels in KBD and OA group were similar. In addition, increased serum levels of TNF-α, IL-1β, COMP, and CTX-II were not associated with the KBD grade.

Authors+Show Affiliations

Orthopedic Department, West China Hospital, Sichuan University, No. 37, Guo Xue Alley Chengdu, 610041 Chengdu, Sichuan, People's Republic of China. 9911122@163.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22068351

Citation

Tang, Xin, et al. "Serum Levels of TNF-α, IL-1β, COMP, and CTX-II in Patients With Kashin-Beck Disease in Sichuan, China." Rheumatology International, vol. 32, no. 11, 2012, pp. 3503-9.
Tang X, Zhou Z, Shen B, et al. Serum levels of TNF-α, IL-1β, COMP, and CTX-II in patients with Kashin-Beck disease in Sichuan, China. Rheumatol Int. 2012;32(11):3503-9.
Tang, X., Zhou, Z., Shen, B., Yang, J., Kang, P., Li, J., Crook, N., Li, Q., Min, L., & Pei, F. (2012). Serum levels of TNF-α, IL-1β, COMP, and CTX-II in patients with Kashin-Beck disease in Sichuan, China. Rheumatology International, 32(11), 3503-9. https://doi.org/10.1007/s00296-011-2172-8
Tang X, et al. Serum Levels of TNF-α, IL-1β, COMP, and CTX-II in Patients With Kashin-Beck Disease in Sichuan, China. Rheumatol Int. 2012;32(11):3503-9. PubMed PMID: 22068351.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum levels of TNF-α, IL-1β, COMP, and CTX-II in patients with Kashin-Beck disease in Sichuan, China. AU - Tang,Xin, AU - Zhou,Zongke, AU - Shen,Bin, AU - Yang,Jing, AU - Kang,Pengde, AU - Li,Jian, AU - Crook,Nicolas, AU - Li,Qi, AU - Min,Li, AU - Pei,Fuxing, Y1 - 2011/11/09/ PY - 2011/04/05/received PY - 2011/10/18/accepted PY - 2011/11/10/entrez PY - 2011/11/10/pubmed PY - 2013/5/18/medline SP - 3503 EP - 9 JF - Rheumatology international JO - Rheumatol. Int. VL - 32 IS - 11 N2 - The aim of the study was to detect differences in serum levels of interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), cartilage oligomeric matrix protein (COMP), type II collagen (CTX-II) between patients with Kashin-Beck disease (KBD) or osteoarthritis (OA) and to assess the correlation between these differences with the clinical grade of KBD. A total of one hundred fifty adult serum samples were collected; these samples belonged to the KBD group (n = 64), the OA group in KBD-prevalent areas (n = 47) and a healthy control group in non-KBD area (n = 39). Serum levels of TNF-α, IL-1β, COMP, and CTX-II were determined by a sandwich enzyme-linked immunosorbent assay, and the results were compared among the 3 groups (KBD/OA/normal) and between the different grades of KBD as well. The serum levels of IL-1β, TNF-α, COMP, and CTX-II were significantly higher in the KBD and OA group than the healthy adult group (P < 0.001), and TNF-α and IL-1β levels in the KBD group were similar to the OA group (for TNF-α, 14.38 ± 7.42 pg/ml vs. 12.61 ± 4.00 pg/ml, respectively, [P = 0.29]; for IL-1β, 141.53 ± 71.35 pg/ml vs. 135.61 ± 68.60 pg/ml, respectively, [P = 0.63]). However, the COMP level was significantly lower and the CTX-II level was higher in the KBD group than in the OA group (for COMP, 7.03 ± 3.11 ng/ml vs. 9.20 ± 3.51 ng/ml, respectively, [P = 0.003]; for CTX-II, 2.23 ± 0.79 ng/ml vs. 1.80 ± 0.87 ng/ml, respectively, [P = 0.026]). Moreover, no significant correlations were found between clinical grade and serum levels of TNF-α, IL-1β, COMP, and CTX-II for the 3 grades of KBD patients (P = 0.645, 0.481, 0.832, and 0.270, respectively). This study showed that serum levels of COMP in KBD patients decreased and CTX-II levels increased compared with the levels in OA patients, but TNF-α and IL-1β levels in KBD and OA group were similar. In addition, increased serum levels of TNF-α, IL-1β, COMP, and CTX-II were not associated with the KBD grade. SN - 1437-160X UR - https://www.unboundmedicine.com/medline/citation/22068351/Serum_levels_of_TNF_α_IL_1β_COMP_and_CTX_II_in_patients_with_Kashin_Beck_disease_in_Sichuan_China_ L2 - https://dx.doi.org/10.1007/s00296-011-2172-8 DB - PRIME DP - Unbound Medicine ER -